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Veliparib

Veliparib structure

CAS No.: 912444-00-9

Chemical Name:: Veliparib

Synonyms: API VELIPARIB;100936;CS-301;A861695;Veliparib;NSC 737664;ABT-888 2HCl;Veliparib Base;VELIPARIBABT-888;Veliparib, >=98%

CBNumber:: CB22489643

Molecular Formula:: C13H16N4O

Molecular Weight:: 244.29

MDL Number:: MFCD16661059

MOL File:: 912444-00-9.mol

MSDS File:: SDS

Last updated:2024-01-02 16:51:54

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Veliparib Properties

Boiling point	579.0±40.0 °C(Predicted)
Density	1.274
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥10.6 mg/mL in EtOH with ultrasonic; ≥6.11 mg/mL in DMSO
form	solid
pka	9.22±0.30(Predicted)
CAS DataBase Reference	912444-00-9
NCI Dictionary of Cancer Terms	veliparib
FDA UNII	01O4K0631N
NCI Drug Dictionary	veliparib
ATC code	L01XK05

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS07
Signal word	Warning
Hazard statements	H341-H373-H361-H302
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501

Veliparib price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	001028	Veliparib	912444-00-9	10mg	$212	2021-12-16	Buy
TRC	A112580	ABT888	912444-00-9	250mg	$340	2021-12-16	Buy
AK Scientific	X7540	Veliparib	912444-00-9	100mg	$384	2021-12-16	Buy
Biosynth Carbosynth	FV16903	Veliparib	912444-00-9	500mg	$400	2021-12-16	Buy
ApexBio Technology	A3002	ABT-888(Veliparib)	912444-00-9	50mg	$219	2021-12-16	Buy

Product number	Packaging	Price	Buy
001028	10mg	$212	Buy
A112580	250mg	$340	Buy
X7540	100mg	$384	Buy
FV16903	500mg	$400	Buy
A3002	50mg	$219	Buy

Veliparib Chemical Properties,Uses,Production

Abstract

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.

Biological activity

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

In vitro

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor，which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays，respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.

In vivo

ABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.

Features

ABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.

References

https://www.abbvie.com/our-science/pipeline/veliparib.html
https://en.wikipedia.org/wiki/Veliparib

Chemical Properties

Off-White Solid

Uses

ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.

Definition

ChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.

Biological Activity

abt-888, also named as veliparib, is poly (adp-ribose) polymerase (parp) inhibitor and has demonstrated excellent in vivo efficacy in a broad spectrum of preclinical tumor models in combination with a variety of cytotoxic agents. parp is involved in dna repair and elevated parp levels can result in resistance to cytotoxic chemotherapy and radiation. so, parp inhibitors hold promise as chemotherapy and radiation sensitizers. abt-888 is also active on microsatellite instability (msi) cell lines harboring mutations in both mre11 and rad50 genes compared to microsatellite stable (mss) cell lines (wild-type for both genes).shivaani kummar, robert kinders, martin e. gutierrez, larry rubinstein, ralph e. parchment, lawrence r. phillips, jiuping ji, anne monks, jennifer a. low, alice chen, anthony j. murgo, jerry collins, seth m. steinberg, helen eliopoulos, vincent l. giranda, gary gordon, lee helman, robert wiltrout, joseph e. tomaszewski and james h. doroshow. phase 0

Veliparib Preparation Products And Raw materials

Raw materials

Preparation Products

Veliparib Suppliers

Global( 223)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7613	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Supplier	Advantage
shandong perfect biotechnology co.ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
BOC Sciences	58

View Lastest Price from Veliparib manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-12	Veliparib (ABT-888) 912444-00-9	US $0.00 / g	1g	98% HPLC	1kg	shandong perfect biotechnology co.ltd
2024-01-02	Veliparib (ABT-888) 912444-00-9	US $200.00-1.00 / KG	1KG	99%, 99.5% Sublimated	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-12-26	Veliparib 912444-00-9	US $0.00-0.00 / kg	1kg	99%, Single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd

Veliparib (ABT-888)
912444-00-9
US $0.00 / g
98% HPLC
shandong perfect biotechnology co.ltd

Veliparib (ABT-888)
912444-00-9
US $200.00-1.00 / KG
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

Veliparib
912444-00-9
US $0.00-0.00 / kg
99%, Single impurity＜0.1
Nanjing Fred Technology Co., Ltd

Veliparib Spectrum

Veliparib(912444-00-9)¹HNMR

912444-00-9(Veliparib)Related Search:

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Talazoparib (BMN 673) PLX4032 Olaparib

1of3

2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide 1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)- 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide A861695 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide ABT-888 (Veliparib, NSC 737664) Veliparib(chiral) 2-[(R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide VELIPARIBABT-888 Veliparib ABT-888,Veliparib ABT-888 2HCl (S)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]iMidazole-4-carboxaMide NSC 737664 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide Veliparib (ABT-888) Veliparib 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (VELIPARIB) Veliparib, >=98% ABT888 hydrochloride ABT-888;ABT 888;ABT888;NSC 737664 Veliparib Base Veliparib free base Veliparib 2-[(2R)-2 100936 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide Veliparib or (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide ABT888 (free base) CS-301 (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide, Veliparib ABT 888 - Veliparib | A 861695 1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]- Veliparib USP/EP/BP 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxami... base Veliparib base 2-(2-methylpyrrolidin-2-yl)-1H-1,3-benzodiazole-4-carboxamide TIANFU CHEM--Veliparib (ABT-888) API VELIPARIB (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide 912444-00-9 PARP Inhibitor Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals API 912444-00-9