4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
![4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Structure](CAS/20181012/GIF/108477-18-5.gif)
- CAS No.
- 108477-18-5
- Chemical Name:
- 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- Synonyms
- NSC-144303;Ubiquitin Isopeptidase-IN-G5;Ubiquitin Isopeptidase Inhibitor I;G5, Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase Inhibitor I, G5;3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide;tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-t;Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303);3,5-Bis(4-nitrobenzylidene)tetrahydro-4H-thiopyran-4-one 1,1-dioxide;4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- CBNumber:
- CB22489683
- Molecular Formula:
- C19H14N2O7S
- Molecular Weight:
- 414.39
- MDL Number:
- MFCD28138111
- MOL File:
- 108477-18-5.mol
- MSDS File:
- SDS
| Melting point | 233.5-234.5 °C |
|---|---|
| Boiling point | 693.0±55.0 °C(Predicted) |
| Density | 1.541±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C,unstable in solution, ready to use. |
| solubility | ≤15mg/ml in DMSO;1mg/ml in dimethyl formamide |
| form | crystalline solid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 662125 | Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem | 108477-18-5 | 10MG | $303 | 2024-03-01 | Buy |
| Cayman Chemical | 21006 | Ubiquitin Isopeptidase Inhibitor I ≥98% | 108477-18-5 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 21006 | Ubiquitin Isopeptidase Inhibitor I ≥98% | 108477-18-5 | 10mg | $175 | 2024-03-01 | Buy |
| Cayman Chemical | 21006 | Ubiquitin Isopeptidase Inhibitor I ≥98% | 108477-18-5 | 25mg | $360 | 2024-03-01 | Buy |
| TRC | U700503 | UbiquitinIsopeptidaseInhibitorI,G5 | 108477-18-5 | 10mg | $210 | 2021-12-16 | Buy |
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Chemical Properties,Uses,Production
Description
Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 μM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 μM). It has also been shown to induce necrosis in apoptosis-resistant DKO cells.
Uses
Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated unsaturated dienone compound.
in vitro
ubiquitin isopeptidase inhibitor i targeted the ubiquitinproteasome system via inhibiting the ubiquitin isopeptidases. ubiquitin isopeptidase inhibitor i could induce a rather unique apoptotic pathway, including a bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the bh3-only protein noxa, stabilization of the inhibitor of apoptosis antagonist smac, but also the involvement of the death receptor pathway. moreover, the treatment of ubiquitin isopeptidase inhibitor i to cell extracts obtained from e1a cells did not inhibit the proteolytic activity of the proteasome, whereas mg-132 potently inhibited the cleavage of the llvy-amc substrate. in addition, noxa induction by ubiquitin isopeptidase inhibitor i could be inhibited by the specific rnai oligos efficiently. when apoptosis was scored, it was found that down-regulation of noxa was able to inhibit but did not suppress apoptosis and caspase activation in response to ubiquitin isopeptidase inhibitor i treatment [1].
IC 50
~30 μm
storage
Store at -20°C
References
[1] e. aleo, c. j. henderson, a. fontanini, et al. identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. cancer research 66(18), 9235-9244 (2006).
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Alabiochem Tech.Co., Ltd. | 0512-58900862 400-0707518 | sales@alabiochem.com | China | 996 | 59 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
View Lastest Price from 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide manufacturers
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![4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/5a1f7e34-ce06-49f8-aa87-54afe3ad4a94.jpg) |
2019-12-24 | 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
108477-18-5
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
108477-18-5
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co