Antimycin A3
- CAS No.
- 522-70-3
- Chemical Name:
- Antimycin A3
- Synonyms
- Nsc58239;Blastmycin;Aids012099;A 80021F34;Aids-012099;antimycina3;BlastMycin, NSC 58239;Antimycin A3 DISCONTINUED, offer A697508;ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer;isovalericacid,n-esterwithn-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-d
- CBNumber:
- CB2259813
- Molecular Formula:
- C26H36N2O9
- Molecular Weight:
- 520.57
- MDL Number:
- MFCD00869273
- MOL File:
- 522-70-3.mol
| Melting point | 170.5-171.5° (Liu); 174-174.5° (Kinoshita) |
|---|---|
| alpha | D26 +64.3° (chloroform) (Liu); D24 +80° (Kinoshita) |
| Boiling point | 603.87°C (rough estimate) |
| Density | 1.2829 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | −20°C |
| solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble |
| form | A solid |
| CAS DataBase Reference | 522-70-3 |
| FDA UNII | 7JMI3P2Y5R |
SAFETY
Risk and Safety Statements
| Hazard Codes | T |
|---|---|
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | 3172 |
| RTECS | NY1502900 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 in mice (mg/kg): 1.8 i.p.; 1.6 s.c. (Watanabe) |
Antimycin A3 Chemical Properties,Uses,Production
Chemical Properties
Antimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.
Uses
Antimycin A3 is a homologue of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A4. Antimycin A3 is a more polar analogue of A1 and A2. Like all antimycins, antimycin A3 is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A3 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active. Lack of availability of the individual antimycin components has hindered greater understanding of the common and unique molecular targets of the components of the antimycin complex.
Definition
ChEBI: Purothionin AII is an amidobenzoic acid.
Potential Exposure
Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.