4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
- CAS No.
- 349085-82-1
- Chemical Name:
- 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
- Synonyms
- CS-2460;GSK137647;GSK137647A;GSK137647A, >98%;FFA4 (GPR120) agonist GS137647A;FFA4 (GPR120) agonist GSK137647A;Benzenesulfonamide, 4-methoxy-N-(2,4,6-trimethylphenyl)-;GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97%;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
- CBNumber:
- CB22635143
- Molecular Formula:
- C16H19NO3S
- Molecular Weight:
- 305.39
- MDL Number:
- MFCD02007969
- MOL File:
- 349085-82-1.mol
- MSDS File:
- SDS
| Boiling point | 438.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.214±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol. |
| form | powder |
| pka | 9.23±0.10(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 349085-82-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1152 | GSK137647A ≥98% (HPLC) | 349085-82-1 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1152 | GSK137647A ≥98% (HPLC) | 349085-82-1 | 25mg | $476 | 2024-03-01 | Buy |
| Alfa Aesar | H57808 | 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97% | 349085-82-1 | 1g | $255 | 2021-12-16 | Buy |
| Alfa Aesar | H57808 | 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97% | 349085-82-1 | 250mg | $80.6 | 2021-12-16 | Buy |
| Cayman Chemical | 17712 | GSK137647A ≥98% | 349085-82-1 | 5mg | $62 | 2024-03-01 | Buy |
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Chemical Properties,Uses,Production
Description
GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2
Uses
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.
in vitro
gsk137647a (50 μm) induced a concentration-dependent increase in glucose (25 mm)-stimulated insulin secretion in min6 mouse insulinoma cell line [1]. in addition, gsk137647a (100 μm) induced a modest increase in glp-1 secretion in the human intestinal cell line nci-h716. moreover, gsk137647a induced intracellular calcium accumulation in u2os cells [1].
in vivo
gsk137647a (50 μm) induced active glp-1 release by mouse circumvallate papillae (cvps) [2].
target
ffa4/gpr120
storage
Store at RT
References
1) Martin?et al. (2012),?Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res.,?53?2256 2) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
View Lastest Price from 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-09-06 | 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
349085-82-1
|
US $1.00 / ASSAYS | 1ASSAYS | 95%~99% | per week:100kg | Career Henan Chemical Co |
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- 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
349085-82-1
- US $1.00 / ASSAYS
- 95%~99%
- Career Henan Chemical Co
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