AT-101
- CAS No.
- 866541-93-7
- Chemical Name:
- AT-101
- Synonyms
- AT101 acetate;AT-101 (AT101);AT-101 USP/EP/BP;AT-101 (acetic acid);(-)-Gossypol acetic acid;Gossypol acetic acid Bcl-2 inhibitor AT101 AT-101;(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid));Bcl-2 Family,Autophagy,(R) ( ) Gossypol acetic acid,Inhibitor,(R)()Gossypol acetic acid,inhibit;[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1);AT-101 [2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. wi
- CBNumber:
- CB22658180
- Molecular Formula:
- C32H34O10
- Molecular Weight:
- 578.60636
- MDL Number:
- MOL File:
- 866541-93-7.mol
| storage temp. | Store at -20°C, protect from light, stored under nitrogen |
|---|---|
| solubility | DMSO : 39.33 mg/mL (67.97 mM) |
| FDA UNII | U9GNI6VT5N |
AT-101 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0004767 | [2,2'-BINAPHTHALENE]-8,8'-DICARBOXALDEHYDE, 1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-5,5'-BIS(1-METHYLETHYL)-, (2R)-, COMPD. WITH ACETIC ACID 95.00% | 866541-93-7 | 5MG | $502.72 | 2021-12-16 | Buy |
| DC Chemicals | DC2015 | AT-101(AT101) >98% | 866541-93-7 | 250mg | $800 | 2021-12-16 | Buy |
| DC Chemicals | DC2015 | AT-101(AT101) >98% | 866541-93-7 | 1g | $1600 | 2021-12-16 | Buy |
| CSNpharm | CSN18501 | AT-101AceticAcid | 866541-93-7 | 1mg | $50 | 2021-12-16 | Buy |
| CSNpharm | CSN18501 | AT-101AceticAcid | 866541-93-7 | 5mg | $71 | 2021-12-16 | Buy |
AT-101 Chemical Properties,Uses,Production
Biological Activity
AT-101, the R-(-) enantiomer of Gossypol acetic acid, binds to Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; no Inhibits the BIR3 domain and BID. Phase 2.
in vitro
AT-101 inhibits a diverse panel of lymphoproliferative malignancies with IC50 of 1.2 μM to 7.4 μM after 24 hours of treatment, 0.7 μM to 3.9 μM after 48 hours of treatment, IC50 of 72 hours after treatment 0.3 μM to 1.7 μM. AT-101 (10 μM) disrupts mitochondrial membrane potential (Δψm) in a concentration- and time-dependent manner in diffuse large B-cell and mantle cell lymphoma cell lines.
in vivo
AT-101 treated SCID beige mice bearing RL-DLBCL xenografts, it was still detectable in plasma, with a mean concentration of 0.49 μM in the 35 mg/kg group and 0.39 μM in the 200 mg/kg group . In SCID beige mice treated with it, peak plasma concentrations were observed after 30 minutes, and the mean plasma concentration in the 200 mg/kg group was almost 4-fold higher than that in the 35 mg/kg group (7.88 μM and 27.78 μM, respectively).
target
| Target | Value |
| Mcl-1 (Cell-free assay) | 0.18 μM(Ki) |
| Bcl-2 (Cell-free assay) | 0.32 μM(Ki) | td>
| Bcl-xL (Cell-free assay) | 0.48 μM(Ki) |
AT-101 Preparation Products And Raw materials
Raw materials
Preparation Products
AT-101 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6709 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28761 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
