AMpkinone
- CAS No.
- 1233082-79-5
- Chemical Name:
- AMpkinone
- Synonyms
- CS-2123;AMpkinone;[1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione, 2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-
- CBNumber:
- CB22695626
- Molecular Formula:
- C31H23NO6
- Molecular Weight:
- 505.52
- MDL Number:
- MFCD28143482
- MOL File:
- 1233082-79-5.mol
AMpkinone price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10631 | Ampkinone ≥95% | 1233082-79-5 | 1mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 10631 | Ampkinone ≥95% | 1233082-79-5 | 5mg | $220 | 2024-03-01 | Buy |
Cayman Chemical | 10631 | Ampkinone ≥95% | 1233082-79-5 | 10mg | $384 | 2024-03-01 | Buy |
Usbiological | 162633 | Ampkinone | 1233082-79-5 | 2.5mg | $382 | 2021-12-16 | Buy |
TRC | A634330 | Ampkinone | 1233082-79-5 | 2.5mg | $100 | 2021-12-16 | Buy |
AMpkinone Chemical Properties,Uses,Production
Uses
Ampkinone is a novel small molecule activator of AMP-activated protein kinase. Ampkinone was shown to exhibit antidiabetic and antiobesity effects.
Biological Activity
ampkinone is an ampk activator.adenosine 5'-monophosphate (amp) activated protein kinase (ampk) has considered as an promising target molecule for the treatment of metabolic disorders, such as obesity and type 2 diabetes.
in vitro
ampkinone was identified as an indirect ampk activator, which was derived from the small molecule library constructed by diversity-oriented synthesis. ampkinone was able to stimulate the phosphorylation of ampk through the indirect activation of ampk in various cell lines. moreover, ampkinone-mediated activation of ampk needed the activity of lkb1 and led to increased glucose uptake in muscle cells [1].
in vivo
animal study found that ampkinone-treated dio mice had significantly reduced total body weight and overall fat mass. histological examination and measurement of lipid parameters showed that ampkinone could effectively improve metabolic abnormalities. these results demonstrated that ampkinone had a potential as a new class of therapeutic agent for antidiabetic and antiobesity treatment through the indirect stimulation of ampk [1].
References
[1] oh, s. ,kim, s.j.,hwang, j.h., et al. antidiabetic and antiobesity effects of ampkinone (6f), a novel small molecule activator of amp-activated protein kinase. journal of medicinal chemistry 53, 7405-7413 (2010).
AMpkinone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2985 | 58 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55896 | 58 |