Tolazoline hydrochloride
- CAS No.
- 59-97-2
- Chemical Name:
- Tolazoline hydrochloride
- Synonyms
- tolavad;LaMbral;arterodyl;Tolazoline HCl;tolazolinechloride;TIMTEC-BB SBB000360;Priscol hydrochloride;imidalinehydrochloride;2-BENZYL-2-IMIDAZOLINE;BENZIDAZOL HYDROCHLORIDE
- CBNumber:
- CB2277815
- Molecular Formula:
- C10H13ClN2
- Molecular Weight:
- 196.68
- MDL Number:
- MFCD00012693
- MOL File:
- 59-97-2.mol
| Melting point | 172-176 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Crystalline Powder |
| color | White to almost white |
| Sensitive | Hygroscopic |
| Merck | 14,9506 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 59-97-2(CAS DataBase Reference) |
| FDA UNII | E669Z6S1JG |
| EPA Substance Registry System | Tolazoline hydrochloride (59-97-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22 | |||||||||
| RIDADR | 2811 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29332900 | |||||||||
| Toxicity | LD50 orl-rat: 1200 mg/kg NIIRDN 6,511,82 | |||||||||
| NFPA 704 |
|
Tolazoline hydrochloride price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3791 | Tolazoline Hydrochloride | 59-97-2 | 5G | $69 | 2024-03-01 | Buy |
| Alfa Aesar | B21764 | 2-Benzyl-2-imidazoline hydrochloride, 99% | 59-97-2 | 25g | $31.65 | 2024-03-01 | Buy |
| Alfa Aesar | B21764 | 2-Benzyl-2-imidazoline hydrochloride, 99% | 59-97-2 | 100g | $90 | 2021-12-16 | Buy |
| Cayman Chemical | 18865 | Tolazoline (hydrochloride) ≥95% | 59-97-2 | 5g | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18865 | Tolazoline (hydrochloride) ≥95% | 59-97-2 | 10g | $50 | 2024-03-01 | Buy |
Tolazoline hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Crystalline Solid
Originator
Priscoline,Ciba,US,1948
Uses
Αn α-adrenergic antagonist. A peripheral vasodilator.
Uses
a-adrenergic antagonist. A peripheral vasodilator
Uses
adrenergic blocker
Definition
ChEBI: Tolazoline hydrochloride is a member of benzenes.
Manufacturing Process
The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.
brand name
Tolazoline is INN and BAN.
Therapeutic Function
Vasodilator
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: change in heart rate, sweating, ulceration or bleeding from duodeum, ulceration or bleeding from small intestine, unspecified vascular effects. When heated to decomposition it emits very toxic fumes of NO, and HCl.
Veterinary Drugs and Treatments
flipping of lips); piloerection;
clear lacrimal & nasal discharge; muscle fasciculations;
apprehensiveness
Uses/Indications
Tolazoline is approved and indicated for the reversal of effects associated
with xylazine in horses. It has also been used for this purpose
in a variety of other species as well, but less safety and efficacy data
is available.
In humans, the primary uses for tolazoline are: treatment of persistent
pulmonary hypertension in newborns, adjunctive treatment
and diagnosis
Tolazoline hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 283 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3684 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from Tolazoline hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-14 | Tolazoline hydrochloride
59-97-2
|
US $1.00-1.00 / KG | 25KG | 99.5% | 5000KG/th | Zibo Shiji Zhonglian Medical Technology Co., Ltd. | |
 |
2023-03-06 | Tolazoline hydrochloride
59-97-2
|
US $50.70 / Kg/Bag | 10g | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2021-11-02 | Tolazoline hydrochloride
59-97-2
|
US $300.00 / KG | 1KG | 995 | 10tons | Baoji Guokang Healthchem co.,ltd |
-
- Tolazoline hydrochloride
59-97-2
- US $1.00-1.00 / KG
- 99.5%
- Zibo Shiji Zhonglian Medical Technology Co., Ltd.
-
- Tolazoline hydrochloride
59-97-2
- US $50.70 / Kg/Bag
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- Tolazoline hydrochloride
59-97-2
- US $300.00 / KG
- 995
- Baoji Guokang Healthchem co.,ltd
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