ChemicalBook >> CAS DataBase List >>(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
- CAS No.
- 300543-56-0
- Chemical Name:
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
- Synonyms
- Levocetirizine Impurity A;Levocetirizine Impurity 2;(R)-Cetirizine EP Impurity A;(R)-1-[(4-Chlorophenyl)phenylmethyl;(R)-1-(p-Chlorobenzhydryl)piperazine;Chlorobenzhydryl Piperazine (F02160);(R)-N-(4-Chlorobenzyl hydryl) piperazine;R(-)-1-[(4-Chlorophenyl)benzyl]piperazine;(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE;(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
- CBNumber:
- CB2299774
- Molecular Formula:
- C17H19ClN2
- Molecular Weight:
- 286.8
- MDL Number:
- MFCD11519277
- MOL File:
- 300543-56-0.mol
- MSDS File:
- SDS
Last updated:2024-03-05 11:58:23
Melting point | 91-93oC |
---|---|
Boiling point | 409.1±0.0 °C(Predicted) |
Density | 1.158 |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) |
pka | 8.99±0.10(Predicted) |
form | Solid |
color | White |
PH | 9.38 at 25℃ and 10.07g/L |
Water Solubility | Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water. |
InChI | InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3 |
InChIKey | UZKBSZSTDQSMDR-SCBJWRGWNA-N |
SMILES | [C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:0,r| |
CAS DataBase Reference | 300543-56-0 |
FDA UNII | 890A9G29PG |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
HS Code | 2933599550 | |||||||||
NFPA 704 |
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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | H63722 | (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97% | 300543-56-0 | 5g | $424.65 | 2024-03-01 | Buy |
Alfa Aesar | H63722 | (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97% | 300543-56-0 | 1g | $99.9 | 2023-06-20 | Buy |
Alfa Aesar | H63722 | (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97% | 300543-56-0 | 250mg | $33.2 | 2023-06-20 | Buy |
TRC | C379574 | (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine | 300543-56-0 | 25mg | $120 | 2021-12-16 | Buy |
Matrix Scientific | 089223 | (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine | 300543-56-0 | 25g | $168 | 2021-12-16 | Buy |
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties,Uses,Production
Uses
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine intermediate in the production of (R)-Cetirizine.
Uses
Intermediate in the production of (R)-Cetirizine (C281106).
Application
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].
References
[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.
Synthesis of (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine from chlorophenyl)phenylMethyl]-1-piperazi-necarboxylic acid, phenyl ester
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 177)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chongqing Ensky Pharmaceutical Co.,Ltd. | +86-23-86815286 +86-13983794297 | sales@ensky-chemical.com | China | 87 | 58 |
Enki Biopharmaceuticals (Shanghai) Limited | +86-0086-2157680326 +8613916707528 | yusu@enkibiopharma.com | China | 47 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-09-20 | (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
300543-56-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2021-01-06 | (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
300543-56-0
|
US $1.00 / g | 1g | 85.0-99.8% | 20tons | Career Henan Chemica Co |
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
300543-56-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
300543-56-0
- US $1.00 / g
- 85.0-99.8%
- Career Henan Chemica Co
300543-56-0((R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine)Related Search:
(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE
(R)-(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
(R)-1-(p-Chlorobenzhydryl)piperazine
Piperazine,1-[(R)-(4-chlorophenyl)phenylMethyl]-
(R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine, 97%
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
Levocetirizine Impurity 2
Levocetirizine Impurity A
(130018-88-1) (-)-1-((4-chlorophenyl)phenylmethyl)piperazine
(R)-Cetirizine EP Impurity A
(R)-1-[(4-Chlorophenyl)phenylmethyl
(R)-Cetirizine EP Impurity A (Levocetirizine Impurity 2)
Levocetirizine Chlorobenzhydryl Piperazine (USP)
(R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine,97%
(R)-(-)-1-[(4-chlorophenyl)phenmethyl]piperazine
(R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine (Cetirizine Impurity)
Chlorobenzhydryl Piperazine (F02160)
TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE
R(-)-1-[(4-Chlorophenyl)benzyl]piperazine
Levocetirizine Impurity 1 (Chlorobenzhydryl piperazine)
(-)-1-[( 4-ChIorophenyI)PhenyImethyI] Piperazine
(R)-Cetirizine EP Impurity A ((R)-Hydroxyzine USP Related Compound A)
(R)-N-(4-Chlorobenzyl hydryl) piperazine
(R)-1-[(4-chlorophenyl)phenyl methyl] Piperazine (Intermediate of Levocetirizine )
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
300543-56-0
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