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ChemicalBook >> CAS DataBase List >>4,5-Dimethyl-1,3-dioxol-2-one

4,5-Dimethyl-1,3-dioxol-2-one

4,5-Dimethyl-1,3-dioxol-2-one Structure
4,5-Dimethyl-1,3-dioxol-2-one structure
CAS No.
37830-90-3
Chemical Name:
4,5-Dimethyl-1,3-dioxol-2-one
Synonyms
DMDO;4,5-Dimethyl-1,3-dioxolen-2-one;DIMETHYLDIOXOLONE;AZATMint-A;3-dioxol-2-one;ORDIMETHYLDIOXOLONE;4,5-Dimethyl-1,3-dio;Olmesartan Impurity 54;Dimethylvinylene carbonate;5-Dimethyl-1,3-dioxol-2-one
CBNumber:
CB2310781
Molecular Formula:
C5H6O3
Molecular Weight:
114.1
MDL Number:
MFCD00135139
MOL File:
37830-90-3.mol
MSDS File:
SDS
Last updated:2023-06-29 17:13:30
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4,5-Dimethyl-1,3-dioxol-2-one Properties

Melting point 78°C
Boiling point 130 °C / 6mmHg
Density 1.181±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol
form Solid
color White
InChIKey QYIOFABFKUOIBV-UHFFFAOYSA-N
CAS DataBase Reference 37830-90-3(CAS DataBase Reference)
NIST Chemistry Reference 1,3-Dioxol-2-one,4,5-dimethyl-(37830-90-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Risk Statements  36/37/38-37-36
Safety Statements  26-36/37/39-36
HS Code  29329990

4,5-Dimethyl-1,3-dioxol-2-one price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich TMT00459 4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3 1G $512 2023-06-20 Buy
TCI Chemical D1920 4,5-Dimethyl-1,3-dioxol-2-one >99.0%(GC) 37830-90-3 25g $49 2024-03-01 Buy
TRC D472660 4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3 100g $395 2021-12-16 Buy
Matrix Scientific 075732 4,5-Dimethyl-1,3-dioxol-2-one 95+% 37830-90-3 100g $399 2021-12-16 Buy
Frontier Specialty Chemicals JK373976 4,5-Dimethyl-1,3-dioxol-2-one 99% 37830-90-3 5g $64 2021-12-16 Buy
Product number Packaging Price Buy
TMT00459 1G $512 Buy
D1920 25g $49 Buy
D472660 100g $395 Buy
075732 100g $399 Buy
JK373976 5g $64 Buy

4,5-Dimethyl-1,3-dioxol-2-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

4,5-Dimethyl-1,3-dioxol-2-one is a dioxolanone derivative used in the preparation of synthetic chemotherapeutic antibiotics such as Prulifloxacin (P838885).

Application

4,5-Dimethyl-1,3-dioxol-2-one is a kind of important medicine intermediate, is mainly used in the modification of many medicines, to synthesize, has optically active chiral drug, thereby improves largely drug effect, reduces drug side effect.

Synthesis

1. distillation column is being housed, air set pipe, mechanical stirrer, add 3-hydroxy-2-butanone 88g, methylcarbonate 90g, tirethylene glycol dme 264g and sodium propylate 0.88g in the three-necked flask of thermometer, at 60-65 ℃ of reacting by heating mixture, carry out transesterification reaction 6h, the methyl alcohol of generation is removed in synchronous distillation, obtains carbonic acid monomethyl 3-hydroxy-2-butanone base ester.
2. improve reaction mixture temperature to 110-115 ℃, keep this thermotonus 5h, continue to steam the by products such as methyl alcohol.
3., after reaction finishes, reaction mixture is to room temperature, add concentrated hydrochloric acid with the neutralization reaction catalyzer to reaction mixture pH value in 7 left and right. After methylcarbonate is reclaimed in fractionation, the underpressure distillation aliphatic ether is appropriate.The distillation residuum is cooled to 0-5 ℃, and crystallization, filtration, obtain product 4,5-dimethyl-1,3-dioxole-2-ketone crude product 62.34g.
4. add recrystallization solvent and 0.62g gac in crude product, be heated to 80 ℃ of return stirring 0.5-1h, filtered while hot, filtrate 60 ℃ of lower evaporation concentration to after having mass crystallization to separate out, adopt cooling bath cooling concentration liquid to 0-5 ℃, the gained solids is dried 2h at 50 ℃ of lower normal pressures.
Can obtain highly purified 4,5-Dimethyl-1,3-dioxol-2-one white crystal, these are highly purified 4 years old, 5-dimethyl-1, the quality of 3-dioxole-2-ketone is 53.88g, yield is 47.26% (calculating with the 3-hydroxy-2-butanone), purity (high performance liquid chromatography) is 99.0%, and fusing point is 77-78 ℃.

4,5-Dimethyl-1,3-dioxol-2-one synthesis

52217-02-4
541-41-3
37830-90-3
Synthesis of 4,5-Dimethyl-1,3-dioxol-2-one from NISTC52217024 and Ethyl chloroformate

4,5-Dimethyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

NISTC52217024 Carbon dioxide Triphosgene

Preparation Products

4,5-Dimethyl-1,3-dioxol-2-one Suppliers

Global( 419)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
+86-23-86815286 +86-13983794297 sales@ensky-chemical.com China 87 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
.GZ HONESTCHEM CO.,LTD 		+86-15013270415 honestchemical@foxmail.com China 247 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2141 58
Tianjin Huiren Chemtech Co., Ltd 		+86-86-22-23707858 +86-86-13672008665 huirentech@foxmail.com China 168 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Supplier Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
58
Henan Bao Enluo International TradeCo.，LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
.GZ HONESTCHEM CO.,LTD 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Tianjin Huiren Chemtech Co., Ltd 		58
Shenzhen Nexconn Pharmatechs Ltd 		58

View Lastest Price from 4,5-Dimethyl-1,3-dioxol-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,5-Dimethyl-1,3-dioxol-2-one pictures 2024-04-24 4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
 US $37600.00-37500.00 / tons 1tons 99% 1000tons Hebei Dangtong Import and export Co LTD
4,5-Dimethyl-1,3-dioxol-2-one pictures 2024-04-24 4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
 US $0.00 / KG 1KG ≥99% Olmesartan intermediate Jinan Finer Chemical Co., Ltd
4,5-Dimethyl-1,3-dioxol-2-one pictures 2023-06-30 4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
 US $10.00 / kg 1kg 99.99% 50000tons Henan Bao Enluo International TradeCo.，LTD

4,5-Dimethyl-1,3-dioxol-2-one Spectrum

4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)MS4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)1HNMR4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)13CNMR4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)IR14,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)IR24,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)Raman

37830-90-3(4,5-Dimethyl-1,3-dioxol-2-one)Related Search:

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DIMETHYLGLYOXIME DISODIUM SALT 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ETHANE Olmesartan 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester
Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole

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4,5-DIMETHYL-1,3-DIOXOL-2-ONE 1,3-DIOXOL-2-ONE, 4,5-DIMETHYL- 4,5-DIMETHYL-1,3-DIOXOLENE-2-ONE (DMDO) 5-Dimethyl-1,3-dioxol-2-one 4,5-Dimethyl-1,3-dioxolen-3-one 4,5-dimethyl-2-oxo-1,3-dioxolene DMDO (4,5-DIMETHYL-1,3-DIOXOL-2-ONE) 4,5-DIMETHYL-1,3-DIOXAL-2-ONE 4,5-DIMETHYL-1,3-DIOXOL-2-ONE (DMDO) 4,5-DIMETHYL-1,3-DIOXOL-2-ONE(OR DIMETHYLDIOXOLONE) 4,5-DIMETHYL-1,3-DIOXOL-2-ONE 99+% 4,5-Dimethyl-1,3-dioxocyclopenten-2-one 4,5-DIMETHYL-1,3-DIOXO-2-ONE 4,5-Dimethyl-1,3-dioxolen-2-one(DDO) Carbonic acid 1,2-dimethylvinylene ester Carbonic acid 2-butene-2,3-diyl ester Dimethyl vinylene carbonate Dimethylvinylene carbonate 4,5-dimethyl-1,3-dioxa-4-cyclopentene-2-one 4,5-Dimethyl-1,3-dio 4,5-Dimethyl-1,3-dioxol-2-one dimethyldioxolone ethyldiox 3-dioxol-2-one diMethyl-2H-1,3-dioxol-2-one 4-5-Methyl-l,3-dioxocyclopenten-2–one 4,5-Dimethyl-1,3-dioxolen-3-one(DMDO) 4,5-dimethyl 1,3-2 oxygen heterocycle pentene-2-ketone 4,5-dimethyl-l,3-dioxolene-2-one (DMDO) 4,5-Dimethyl-1,3-dioxol-2-one USP/EP/BP Olmesartan Dimethyl Impurity Olmesartan DMDO-Cl Impurity Ⅴ 4,5-Dimethyl-1,3-dioxol-2-one> ORDIMETHYLDIOXOLONE Olmesartan DMDO-CL Impurity Ⅱ Olmesartan Medoxomil Impurity 37 AZATMint-A Olmesartan Impurity 54 DIMETHYLDIOXOLONE 4,5-Dimethyl-1,3-dioxolen-2-one DMDO 4,5-Dimethyl-1,3-dioxole-2-one(DMDO) 4.5 Dimethyl 1.3 dioxane 2-one 37830-90-3 Pharmaceutical Intermediates Agricultural chemicals(bactericide) Oxygen cyclic compounds Fluorobenzene