4-Pyridinecarboxaldehyde
- CAS No.
- 872-85-5
- Chemical Name:
- 4-Pyridinecarboxaldehyde
- Synonyms
- ISONICOTINALDEHYDE;PYRIDINE-4-CARBALDEHYDE;PYRIDINE-4-CARBOXALDEHYDE;4-PYRIDINECARBALDEHYDE;PYRIDINE-4-ALDEHYDE;4-pyrdine aldehyde;Isonicotinic aldehyde;4-PyridineCarboxyaldehyde;Pyridin-4-al;4-Formylpyrdine
- CBNumber:
- CB2315397
- Molecular Formula:
- C6H5NO
- Molecular Weight:
- 107.11
- MDL Number:
- MFCD00006425
- MOL File:
- 872-85-5.mol
- MSDS File:
- SDS
| Melting point | -4--2°C |
|---|---|
| Boiling point | 71-73 °C/10 mmHg (lit.) |
| Density | 1.137 g/mL at 20 °C (lit.) |
| vapor pressure | 0.02 hPa (20 °C) |
| refractive index |
n |
| Flash point | 130 °F |
| storage temp. | Store at +2°C to +8°C. |
| solubility | 20g/l |
| pka | 12.05(at 30℃) |
| form | liquid (clear) |
| color | clear brown-yellow |
| PH | 7-8 (H2O, 20℃)(saturated aqueous solution) |
| Water Solubility | 20 g/L (20 ºC) |
| Sensitive | Air Sensitive |
| BRN | 105342 |
| InChIKey | BGUWFUQJCDRPTL-UHFFFAOYSA-N |
| LogP | 0.12 at 30℃ and pH7 |
| CAS DataBase Reference | 872-85-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | P577557492 |
| NIST Chemistry Reference | 4-Pyridinecarboxaldehyde(872-85-5) |
| EPA Substance Registry System | 4-Pyridinecarboxaldehyde (872-85-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H317-H412 | |||||||||
| Precautionary statements | P261-P272-P273-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 36/37/38-10 | |||||||||
| Safety Statements | 26-36-36/37/39-16 | |||||||||
| RIDADR | UN 1989 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | NR9400000 | |||||||||
| F | 8-10-23 | |||||||||
| Hazard Note | Irritant/Keep Cold/Air Sensitive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333999 | |||||||||
| Toxicity | LD50 orally in Rabbit: 2355 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704 |
|
4-Pyridinecarboxaldehyde price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P62402 | 4-Pyridinecarboxaldehyde 97% | 872-85-5 | 25g | $67.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | P62402 | 4-Pyridinecarboxaldehyde 97% | 872-85-5 | 100g | $245 | 2024-03-01 | Buy |
| TCI Chemical | I0143 | 4-Pyridinecarboxaldehyde >96.0%(GC) | 872-85-5 | 25mL | $43 | 2024-03-01 | Buy |
| TCI Chemical | I0143 | 4-Pyridinecarboxaldehyde >96.0%(GC) | 872-85-5 | 500mL | $581 | 2021-12-16 | Buy |
| Alfa Aesar | A10656 | Pyridine-4-carboxaldehyde, 97% | 872-85-5 | 25g | $44.4 | 2024-03-01 | Buy |
4-Pyridinecarboxaldehyde Chemical Properties,Uses,Production
Flavor Type
Flavor Type: fruity
Chemical Properties
4-Pyridinecarboxaldehyde(4PCA) is a slightly yellow oily liquid. Its relative density is 1.122, and its refractive index is 1.5352 (25°C). Flash point is 54 ° C. 4-Pyridinecarboxaldehyde is soluble in water and ether.4-Pyridinecarboxaldehyde, also commonly called pyridine-2-carboxaldehyde, is an organic compound with the formula NC5H4CHO. 4-Pyridinecarboxaldehyde is a colorless oily liquid with a distinctive odor. Older samples are often brown-colored owing to impurities.
Uses
4-Pyridinecarboxaldehyde is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.4-Pyridinecarboxaldehyde and some of its derivatives have also been reported as useful transamination reagents to introduce ketone or aldehyde groups onto the N-termini of antibodies for subsequent site-specifically conjugate aminooxy-functionalized molecules (including fluorescent dyes, polyethylene glycol, or porphyrins) to these entities.
4-Pyridinecarboxaldehyde can be used for the synthesis of: β-Unsaturated amides by coupling with N,N-disubstituted formamides; meso-Substituted A3-corroles; N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs); 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents; 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.
Chemical Properties
clear yellow-brown liquid. soluble in water and ether.
Uses
4-Pyridinecarboxaldehyde can be used for the synthesis of:
- ?,β-Unsaturated amides by coupling with N,N-disubstituted formamides.
- meso-Substituted A3-corroles.
- N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs).
- 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents.
- 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.
Uses
4-Pyridinecarboxaldehyde, is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.
Preparation
4-Pyridinecarbaldehyde is synthesized by oxidation of 4-picoline. The mixed gas of 4-picoline and air is passed through the vanadium-molybdenum catalyst layer heated to 400°C, and oxidized to generate 4-pyridinecarbaldehyde.
Synthesis Reference(s)
Synthetic Communications, 20, p. 3385, 1990 DOI: 10.1080/00397919008051576
Purification Methods
Purified as for pyridine-2-aldehyde. [Beilstein 21 III/IV 2529, 21/7 V 351.]
4-Pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +8613916485955 | shivshanghai@yahoo.com | India | 132 | 58 |
| Siyang Liaoning Biochemical Products Co. Ltd | +86-15221114306; +8615221114306 | 2594582574@qq.com | China | 574 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 | xinhao-6@xinhaoshengwu.com | China | 350 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
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View Lastest Price from 4-Pyridinecarboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | 4-Pyridinecarboxaldehyde
872-85-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500000KG | Hebei Yibangte Import and Export Co. , Ltd. | |
 |
2024-04-22 | 4-Pyridinecarboxaldehyde
872-85-5
|
US $6.00-5.00 / kg | 1kg | 95% | 1000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-04-02 | 4-Pyridinecarboxaldehyde
872-85-5
|
US $10.00-100.00 / kg | 1kg | 99% | 100 tons | Wuhan Xinhao Biotechnology Co., Ltd |
-
- 4-Pyridinecarboxaldehyde
872-85-5
- US $0.00-0.00 / KG
- 99%
- Hebei Yibangte Import and Export Co. , Ltd.
-
- 4-Pyridinecarboxaldehyde
872-85-5
- US $6.00-5.00 / kg
- 95%
- hebei hongtan Biotechnology Co., Ltd
-
- 4-Pyridinecarboxaldehyde
872-85-5
- US $10.00-100.00 / kg
- 99%
- Wuhan Xinhao Biotechnology Co., Ltd