ChemicalBook >> CAS DataBase List >>BMS813160
BMS813160
- CAS No.
- 1286279-29-5
- Chemical Name:
- BMS813160
- Synonyms
- CS-2742;BMS813160;BMS-813160;BMS813160;BMS 813160;N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;Inhibitor,CC chemokine receptor,CCR,dual antagonist,peritonitis,CD11b,BMS-813160,inflammation,CTX,thioglycollate,BMS813160,inhibit,mouse,oral;Acetamide, N-[(1R,2S,5R)-5-[(1,1-dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]-
- CBNumber:
- CB23364411
- Molecular Formula:
- C25H40N8O2
- Molecular Weight:
- 484.64
- MDL Number:
- MFCD31540731
- MOL File:
- 1286279-29-5.mol
Last updated:2023-06-08 09:03:09
| Density | 1.31±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light |
| solubility |
DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM) Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM) |
| form | A crystalline solid |
| pka | 15.46±0.60(Predicted) |
| FDA UNII | 83U7957287 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H334-H317-H341-H361-H370-H335-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
BMS813160 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28421 | BMS 813160 | 1286279-29-5 | 1mg | $242 | 2024-03-01 | Buy |
| Cayman Chemical | 28421 | BMS 813160 | 1286279-29-5 | 5mg | $965 | 2024-03-01 | Buy |
| TRC | B595925 | BMS-813160 | 1286279-29-5 | 1mg | $305 | 2021-12-16 | Buy |
| ChemScene | CS-0033469 | BMS-813160 99.89% | 1286279-29-5 | 10mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0033469 | BMS-813160 99.89% | 1286279-29-5 | 5mg | $280 | 2021-12-16 | Buy |
BMS813160 Chemical Properties,Uses,Production
Description
BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.
Uses
BMS-813160, a dual CCR2/CCR5 chemokine antagonist.
BMS813160 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 50)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 2698 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 13720134139 | orders@jknbiochem.com | China | 4959 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3421 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 |
1286279-29-5(BMS813160)Related Search:
CS-2742
BMS-813160;BMS813160;BMS 813160
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide
BMS813160
Acetamide, N-[(1R,2S,5R)-5-[(1,1-dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]-
Inhibitor,CC chemokine receptor,CCR,dual antagonist,peritonitis,CD11b,BMS-813160,inflammation,CTX,thioglycollate,BMS813160,inhibit,mouse,oral
1286279-29-5