DOMOIC ACID
- CAS No.
- 14277-97-5
- Chemical Name:
- DOMOIC ACID
- Synonyms
- C13732;Domoic;omoicaci;NSC 288031;DOMOIC ACID;L-Domic acid;(-)-Domic acid;DoMoic Acid-d3;(-)-DoMoic Acid-d3;Domoic acid, 100ppm
- CBNumber:
- CB2359498
- Molecular Formula:
- C15H21NO6
- Molecular Weight:
- 311.33
- MDL Number:
- MFCD06795841
- MOL File:
- 14277-97-5.mol
| Melting point | 213-217℃ |
|---|---|
| Boiling point | 451.38°C (rough estimate) |
| Density | 1.1800 (rough estimate) |
| refractive index | 1.5130 (estimate) |
| storage temp. | -20°C |
| solubility | methanol: 0.6 mg/mL |
| form | solid |
| pka | 2.08±0.60(Predicted) |
| color | white |
| Water Solubility | Soluble in water at 8mg/ml. Soluble in methanol at 0.6mg/ml. |
| Merck | 13,3451 |
| BRN | 46376 |
| Stability | Light Sensitive |
| FDA UNII | M02525818H |
| EPA Substance Registry System | Domoic acid (14277-97-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H370 |
| Precautionary statements | P260-P264-P270-P301+P312-P308+P311-P405 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
| RTECS | UX9665100 |
| Toxicity | An excitory amino acid isolated from the red alga Chondria armata. A structural analog of kainic acid and domoic acid has been shown to be responsible for the shellfish poisoning associated with eating certain cultured blue mussels. |
DOMOIC ACID price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D6152 | Domoic acid ≥90% (HPLC) | 14277-97-5 | 1mg | $234 | 2023-01-07 | Buy |
| Sigma-Aldrich | D6152 | Domoic acid ≥90% (HPLC) | 14277-97-5 | 5mg | $772 | 2023-01-07 | Buy |
| Cayman Chemical | 21433 | Domoic Acid ≥98% | 14277-97-5 | 500μg | $99 | 2021-12-16 | Buy |
| Cayman Chemical | 21433 | Domoic Acid ≥98% | 14277-97-5 | 1mg | $158 | 2021-12-16 | Buy |
| Tocris | 0269 | Domoic acid ≥95%(HPLC) | 14277-97-5 | 500U | $197 | 2021-12-16 | Buy |
DOMOIC ACID Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Labelled Domoic Acid. Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning ass ociated with ingestion of certain cultured blue mussels. Domoic Acid is a structural analog of Kainic acid (K135000).
Uses
Domoic acid has been used:
- as an excitatory neurotoxin to determine brain transcriptional response
- to study its cytotoxic, genotoxic and immunotoxic effects on the marine mussel M. edulis
- to study its neurobehavioral effects on mouse fetuses
Uses
Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning associated with ingestion of certain cultured blue mussels. Domoic acid is a structural analog of Kainic acid (K135000). DA. EU regulated marine toxin.
Definition
ChEBI: A L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is an analog of kainic acid and is the neurotoxin associated with the a nesic shellfish poisoning (ASP).
General Description
Domoic acid, a heterocyclic amino acid neurotoxin is synthesized by various marine algaes. It possess some structural similarity to kainic acid.
Biological Activity
More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.
Biochem/physiol Actions
Domoic acid is a potent agonist at receptors for excitatory amino acids glutamate and kainate. It has highest affinity for AMPA/kainate receptor of any kainate agonist. It can causes excessive excitation of neurons leading to depletion of energy stores.
Purification Methods
Domoic acid (~300 mg) is purifed on a Dowex1 column (3.5 x 40 mm, 200-400 mesh, acetate form), washed with H2O until neutral, then eluted with increasing concentrations of AcOH (8L) from 0 to 0.25M. The fraction containing domoic acid (in 50mL) is collected, evaporated to dryness under reduced pressure and recrystallised from aqueous EtOH. It is a glutamate and a Kainate receptor agonist. [Impellizzeri et al. Phytochemistry 14 1549 1975, Takemoto & Diago Arch Pharm 293 627 1960, Beilstein 22/4 V 371.]
DOMOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35906 | 56 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9986 | 55 |