BENORILATE
- CAS No.
- 5003-48-5
- Chemical Name:
- BENORILATE
- Synonyms
- to125;benoral;benortan;salipran;win11450;Benno fat;benorilato;Fenasprate;BENORILATE;BENORYLATE
- CBNumber:
- CB2397764
- Molecular Formula:
- C17H15NO5
- Molecular Weight:
- 313.3
- MDL Number:
- MFCD00864257
- MOL File:
- 5003-48-5.mol
- MSDS File:
- SDS
| Melting point | 177-181℃ |
|---|---|
| Boiling point | 453.11°C (rough estimate) |
| Density | 1.2016 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 14.17±0.70(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | 20mg/L(21 ºC) |
| Merck | 14,1045 |
| CAS DataBase Reference | 5003-48-5(CAS DataBase Reference) |
| FDA UNII | W1QX9DV96G |
| ATC code | N02BA10 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| RTECS | VO0720000 |
| HS Code | 2924.29.7790 |
| Toxicity | LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson) |
BENORILATE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4827 | Benorilate >98.0%(HPLC)(N) | 5003-48-5 | 5g | $29 | 2024-03-01 | Buy |
| TCI Chemical | B4827 | Benorilate >98.0%(HPLC)(N) | 5003-48-5 | 25g | $83 | 2024-03-01 | Buy |
| TRC | B165700 | Benorilate | 5003-48-5 | 25g | $225 | 2021-12-16 | Buy |
| Usbiological | 162750 | Benorilate | 5003-48-5 | 1g | $403 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 68003 | Benorilate | 5003-48-5 | 10g | $650 | 2021-12-16 | Buy |
BENORILATE Chemical Properties,Uses,Production
Description
Benorylate is the acetaminophen ester of acetylsalicylic acid, designed to provide a less irritating form of aspirin. Gastrointestinal blood loss in patients taking benorylate is less than that during therapy with soluble aspirin. Benorylate has been found to be as effective as aspirin for the treatment of chronic rheumatic disorders.
Originator
Benortan,Winthrop,Switz.
Uses
Benorilate is a codrug of Acetylsalicylic Acid (A187780) and Acetaminophen (A161220) and is used as an anti-inflammatory and antipyretic medication.
Definition
ChEBI: Benorilate is a carbonyl compound.
Manufacturing Process
Example 1: 65 grams of N-acetyl-p-aminophenol were slurried with 400 ml of
water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly
added to the mixture with stirring, the temperature being maintained between
10°and 15°C. To the solution obtained, 75 grams of acetyl salicoyl chloride
were added with vigorous stirring over a period of 1/2 hr, the solution being
maintained at a temperature of about 10°C. Towards the end of the reaction
the pH was checked and adjusted to greater than 10 by the addition of a
small amount of 20% sodium hydroxide. After all the acid chloride had been
added, vigorous stirring was continued for half an hour during which time the
crude product separated out. This product was filtered off, washed thoroughly
with water and recrystallized from ethanol.
Example 2: 65 grams of sodium N-acetyl-p-aminophenol were slurried with
500 grams of dry benzene and 80 grams of acetyl salicoyl chloride added. The
mixture was heated under reflux for four hours and filtered hot. The excess
benzene was removed under vacuum and the crude acetyl salicyclic acid ester
of N-acetyl-p-aminophenol crystallized from ethanol.
brand name
Benoral (Sterling Winthrop);Benolat;Benorile;Benotamol;Bentum;Doline;Durium;Duvium;Faw 76;Quinexin;Sinalgin;Spierifex;Triadol;Vetedol;Win 11450;Winolate;Winorlate;Winorylate;Winrolate;Wiolate.
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
World Health Organization (WHO)
Benorilate is the acetylsalicylic ester of paracetamol. See WHO comment for acetylsalicylic acid.
BENORILATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 1696 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3632 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
View Lastest Price from BENORILATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | Benorilate
5003-48-5
|
US $15.00 / kg | 1kg | 99.912% | 10ton | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-03-22 | Benorilate
5003-48-5
|
US $100.00-1.00 / kg | 1kg | 99% | 20 tons | Liaoning Pharmaceutical Innovation Co., Ltd | |
 |
2023-07-04 | BENORILATE
5003-48-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Benorilate
5003-48-5
- US $15.00 / kg
- 99.912%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Benorilate
5003-48-5
- US $100.00-1.00 / kg
- 99%
- Liaoning Pharmaceutical Innovation Co., Ltd
-
- BENORILATE
5003-48-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd