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(-)-MK-801 MALEATE

(-)-MK-801 MALEATE structure

CAS No.: 77086-22-7

Chemical Name:: (-)-MK-801 MALEATE

Synonyms: mk801;(+)MK108;(+)MK801;MK 801 ;MK801;(-)-MK-801 MALEATE;Dizocipine maleate;(+)Mk801/MK801/MK-801;(+)-MK-801·Maleic acid;MK-801(Dizocilpine)Maleate;(+/-)-mk-801 hydrogen maleate

CBNumber:: CB2407483

Molecular Formula:: C20H19NO4

Molecular Weight:: 337.38

MDL Number:: MFCD00082465

MOL File:: 77086-22-7.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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(-)-MK-801 MALEATE Properties

Melting point	208.5-210°
alpha	D20 +114° (c = 0.0128 g/2 ml ethanol)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO: >20 mg/mL
form	solid
color	white
optical activity	[α]25/D +117°, c = 1 in methanol(lit.)
InChIKey	QLTXKCWMEZIHBJ-FWHYOZOBSA-N
FDA UNII	6LR8C1B66Q

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS06

Signal word

Danger

Hazard statements

H372-H370-H361-H301-H319

Precautionary statements

P260-P264-P270-P314-P501-P260-P264-P270-P307+P311-P321-P405-P501-P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501

Safety Statements

22-24/25

WGK Germany

RTECS

HP1093575

NFPA 704

	0
4		0

(-)-MK-801 MALEATE price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M107	(+)-MK-801 hydrogen maleate powder	77086-22-7	5mg	$119	2024-03-01	Buy
Sigma-Aldrich	475878	(+)-MK 801 Maleate	77086-22-7	10mg	$152	2022-05-15	Buy
Alfa Aesar	J63917	Dizocilpine maleate, 99+%	77086-22-7	10mg	$120	2024-03-01	Buy
Alfa Aesar	J63917	Dizocilpine maleate, 99+%	77086-22-7	50mg	$369	2024-03-01	Buy
Cayman Chemical	10009019	(+)-MK-801 (hydrogen maleate) ≥99%	77086-22-7	10mg	$72	2024-03-01	Buy

Product number	Packaging	Price	Buy
M107	5mg	$119	Buy
475878	10mg	$152	Buy
J63917	10mg	$120	Buy
J63917	50mg	$369	Buy
10009019	10mg	$72	Buy

(-)-MK-801 MALEATE Chemical Properties,Uses,Production

Uses

Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.

Uses

(-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.

Uses

(-)-MK-801 MALEATE is probe for NMDA receptors

Definition

ChEBI: Dizocilpine maleate is a maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid. It has a role as an anaesthetic, an anticonvulsant, a neuroprotective agent, a nicotinic antagonist and a NMDA receptor antagonist. It is a maleate salt and a tetracyclic antidepressant. It contains a dizocilpine(1+).

General Description

A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

Biological Activity

(-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Primary TargetNMDA receptor

storage

Room temperature

References

[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8.

(-)-MK-801 MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-MK-801 MALEATE Suppliers

Global( 149)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2255	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
GLR Innovations	+91 9891111994	info@glrgroup.in	India	4542	58

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Career Henan Chemica Co	58
Xi'an MC Biotech, Co., Ltd.	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Henan Alfa Chemical Co., Ltd	58
InvivoChem	58
GLR Innovations	58

View Lastest Price from (-)-MK-801 MALEATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-06	(-)-MK-801 MALEATE 77086-22-7	US $1.00 / KG	1KG	99%HPLC	100KG	Career Henan Chemical Co

(-)-MK-801 MALEATE
77086-22-7
US $1.00 / KG
99%HPLC
Career Henan Chemical Co

(-)-MK-801 MALEATE Spectrum

(-)-MK-801 MALEATE(77086-22-7)¹HNMR

77086-22-7((-)-MK-801 MALEATE)Related Search:

(-)-MK 801 MALEATE, >99% (-)-MK-801 MALEATE (+)-MK 801 MALEATE,(-)-MK 801 MALEATE

(5S,10R)-(-)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE MALEATE d)cyclohepten-5,10-imine,10,11-dihydro-5-methyl-5h-dibenzo((5s)-5h-dibenzo((z)-2-b mk801 (-)-MK-801 MALEATE (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate (+)-MK-801 HYDROGEN MALEATE (DIZOCILPINE MALEATE) (5S,10R)-(+)-5-Methyl-10,11-dihydro-(5H)-dibenzo[a.d]cycloheptene-5,10-iminemaleate Dizocilpine hydrogen maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate Dizocilpine hydrogen maleate [5R,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5β,10β-imine [5R,10S,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine [5R,10S,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5β,10β-imine (+)-MK-801·Maleic acid Dizocipine maleate (+)Mk801/MK801/MK-801 (5S)-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine (Z)-2-butenedioate 5-Methyl-10,11-dihydro-5H-5,10-epiMinodibenzo[a,d][7]annulene (2Z)-but-2-enedioate (+)MK108 DIZOCILPINE MALEATE;DIZOCILPINE HYDROGEN MALEATE;(+)-MK 801;MK 801;MK801 (+)MK801 (+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem MK 801 ;MK801 MK-801(Dizocilpine)Maleate Dizocilpine Maleate [(+)-MK 801 maleate (+/-)-mk-801 hydrogen maleate (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate inhibit,anticonvulsant,neurotransmitter,noncompetitive,ambulation,MK-801,Dizocilpine Maleate,voltage,hyperlocomotion,Ionotropic glutamate receptors,Inhibitor,iGluR,MK801,Dizocilpine (5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate 77086-22-7 C16H15NC4H4O4 Cell Biology Cell Signaling and Neuroscience BioChemical Ion Channels Ionotropic Glutamate Receptor Modulators Ligand-Gated Ion Channels Glutamate Glutamate receptor APIs