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Tolclofos-methyl

CAS No.
57018-04-9
Chemical Name:
Tolclofos-methyl
Synonyms
S-3349;RIZOLEX;Basilex;Risolex;Risolex(TM);Tolcofos-methyl;olclofos-methyl;Methyl tolclofo;TOLCLOFOS-METHYL;Methyl tolclofos
CBNumber:
CB2451996
Molecular Formula:
C9H11Cl2O3PS
Molecular Weight:
301.13
MDL Number:
MFCD00078741
MOL File:
57018-04-9.mol
Last updated:2023-05-25 18:01:03

Tolclofos-methyl Properties

Melting point 78-80°C
Boiling point 338.5±52.0 °C(Predicted)
Density 1.401±0.06 g/cm3(Predicted)
vapor pressure 1.84 x 10-3 (Pa 25 °C)
Flash point >100 °C
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly)
Water Solubility 1.10 mg l-1 (25 °C)
Merck 13,9587
BRN 2136521
InChIKey OBZIQQJJIKNWNO-UHFFFAOYSA-N
LogP 4.560
CAS DataBase Reference 57018-04-9(CAS DataBase Reference)
FDA UNII G42OQL6F5B
NIST Chemistry Reference Phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl ester(57018-04-9)
Pesticides Freedom of Information Act (FOIA) Rizolex
EPA Substance Registry System Tolclofos-methyl (57018-04-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H410
Precautionary statements  P261-P272-P273-P280-P302+P352-P333+P313
Hazard Codes  Xi,N
Risk Statements  43-50/53
Safety Statements  22-24/25-61-60-37-24
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  TF0460000
HS Code  29201900
Toxicity LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami)

Tolclofos-methyl price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 31209 Tolclofos-methyl PESTANAL 57018-04-9 250mg $49.56 2024-03-01 Buy
TRC T535265 Tolclofos-methyl 57018-04-9 1g $215 2021-12-16 Buy
ChemScene CS-5201 Tolclofos-methyl 96.51% 57018-04-9 500mg $60 2021-12-16 Buy
American Custom Chemicals Corporation PST0000303 TOLCLOFOS-METHYL 95.00% 57018-04-9 5MG $501.25 2021-12-16 Buy
Medical Isotopes, Inc. 99597 Tolclofos-methyl 57018-04-9 1g $575 2021-12-16 Buy
Product number Packaging Price Buy
31209 250mg $49.56 Buy
T535265 1g $215 Buy
CS-5201 500mg $60 Buy
PST0000303 5MG $501.25 Buy
99597 1g $575 Buy

Tolclofos-methyl Chemical Properties,Uses,Production

Uses

Tolclofos-methyl is a non-systemic organophosphorus fungicide with both protective and curative activities that control soil-borne diseases caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula ishikariensis in/on potatoes, sugar beet, cotton and peanuts.

Uses

Agricultural fungicide.

Definition

ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.

Metabolic pathway

Tolclofos-methyl underwent common degradation and metabolic pathways in water, soil, plants and animals. These reactions are well documented for most organophosphorus compounds and include oxidative desulfuration, hydroxylation/oxidation of the 4-methyl group to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage, O-demethylation and conjugation. In addition to the above reactions, photolytic isomerisation to the thionate (P=S) was also observed. A schematic presentation of the primary metabolic pathways for tolclofosmethyl is illustrated in Scheme 1.

Degradation

[14C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at pH 5, 7 and 9 at 22°C with DT50 values of 139, 417 and 238 days, respectively. Higher temperature led to a more rapid hydrolysis and two hydrolysis products were detected. O-Demethylation and oxidative desulfuration were the major reactions to yield 2,6-dichloro-p-tolyl methyl hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop- tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation with DT50 values of 44 days (in distilled water), 15-28 days (in natural river and pond water) and less than 2 days in 2% acetone/water. The major degradation reactions included oxidative desulfuration to yield compound 3 and O-demethylation to yield compound 2. The major photodegradation products in river and pond waters and soil thinlayer surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6- dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984). In acetone solution, demethylation of the isomerisation product [2,6- dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop- tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl dihydrogen phosphate (8) as the major photodegradates (Mikami et al., 1984).

Toxicity evaluation

Its acute oral toxicity is very low in comparison with a thio-ester type of other organophosphorus fungicides (edifenphos, iprobenfos, and pyrazophos).

2432-12-4
2524-03-0
7757-82-6
57018-04-9
Synthesis of Tolclofos-methyl from 2,6-Dichloro-4-methylphenol and Dimethyl chlorothiophosphate and Sodium sulfate

Tolclofos-methyl Preparation Products And Raw materials

Global( 155)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5990 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Henan Alfa Chemical Co., Ltd
+8618339805032 alfa4@alfachem.cn China 12759 58

View Lastest Price from Tolclofos-methyl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tolclofos-methyl pictures 2023-09-06 Tolclofos-methyl
57018-04-9
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • Tolclofos-methyl pictures
  • Tolclofos-methyl
    57018-04-9
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
2,6-dichloro-4-methylphenyl o,o-dimethyl phosphorothioate Dimethyl O-(2,6-dichloro-4-methylphenyl) phosphorothioate S-3349 RIZOLEX O-(2,6-DICHLORO-4-METHYLPHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE TOLCLOFOS-METHYL Basilex Dichloro-4-methylphenyl-O,O-dimethyl phosphorothioate o-(2,6-Dichloro-4-methylphenyl) o,o-dimethyl thiophosphate o-(2,6-dichloro-p-tolyl)o,o-dimethylesterofphosphorothioicacid O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphate o,o-dimethylo-(2,6-dichloro-4-methylphenyl)phosphorothioate Phosphorothioic acid, O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl ester Phosphorothioicacid,esters,O-(2,6-dichloro-4-methylphenyl)-O,O-dimethylester phosphorothioicacid,o-(2,6-dichloro-4-methylphenyl)o,o-dimethylester phosphorothioicacid,o-(2,6-dichloro-p-tolyl)o,o-dimethylester Risolex Tolcofos-methyl BENZTHIAZURON PESTANAL, 100 MG tolclofos-methyl (bsi,iso) TOLCHLOFOS-METHYL O,O-dimethyl-O-(2,6-dichloro-p-tolyl) phosphorothioate (2,6-Dichloro-4-methylphenoxy)-dimethoxy-sulfanylidenephosphorane Phosphorothioic acid O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl Thiophosphoric acid O-(2,6-dichloro-4-methylphenyl)O,O-dimethyl ester Thiophosphoric acid O,O-dimethyl O-(2,6-dichloro-4-methylphenyl) ester Thiophosphoric acid=O-(2,6-dichloro-4-methylphenyl)=O,O-dimethyl ester O-2,6-DICHLORO-P-TOLYLO,O-DIMETHYLPHOSPHOROTHIOATE Tolclofos-methyl Standard Tolclofos-methyl Solution, 100ppm Tolclofos-Methyl 500mg [57018-04-9] Risolex(TM) Tolclofos-methyl Solution, 1000ppm Tolclofos-methyl@1000 μg/mL in Acetone Tolclofos-methyl @100 μg/mL in MeOH Tolchlophos-methyl Tolclofos-MethylStock,100mg/L,1ml olclofos-methyl TIANFU-CHEM - Tolclofos-methyl Methyl tolclofos Methyl tolclofo Tolclofos-methyl Solution in Methanol 57018-04-9 C9H11Cl2O3PS FUNGICIDE