SCOPOLAMINE METHYL NITRATE
- CAS No.
- 6106-46-3
- Chemical Name:
- SCOPOLAMINE METHYL NITRATE
- Synonyms
- skopyl;viscope;mescomine;skopolate;itrate,(-)-tropate;HYOSCINEMETHONITRATE;Scopolamine (nitrate);dwithmethylnitrate1:1);HYOSCINE METHYL NITRATE;METHSCOPOLAMINE NITRATE
- CBNumber:
- CB2453455
- Molecular Formula:
- C18H24N2O7
- Molecular Weight:
- 380.4
- MDL Number:
- MFCD00078239
- MOL File:
- 6106-46-3.mol
| Melting point | 199 °C |
|---|---|
| refractive index | -25 ° (C=1, H2O) |
| Water Solubility | almost transparency in Water |
| form | powder to crystal |
| color | White to Almost white |
| Merck | 14,8406 |
| CAS DataBase Reference | 6106-46-3(CAS DataBase Reference) |
| FDA UNII | K0813KQM3V |
| EPA Substance Registry System | Methylscopolamine nitrate (6106-46-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H330-H300-H310 | |||||||||
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Hazard Codes | T,T+ | |||||||||
| Risk Statements | 23/24/25-26/27/28 | |||||||||
| Safety Statements | 36/37/39-45-25 | |||||||||
| RIDADR | UN 1544 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YM3675150 | |||||||||
| HS Code | 2939.80.0000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
SCOPOLAMINE METHYL NITRATE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | S0230 | Scopolamine Methyl Nitrate >98.0%(HPLC)(T) | 6106-46-3 | 1g | $158 | 2024-03-01 | Buy |
| TCI Chemical | S0230 | Scopolamine Methyl Nitrate >98.0%(HPLC)(T) | 6106-46-3 | 5g | $512 | 2024-03-01 | Buy |
| TRC | S200068 | (-)ScopolamineMethylnitrate | 6106-46-3 | 100mg | $45 | 2021-12-16 | Buy |
| Chem-Impex | 32523 | Scopolaminemethylnitrate,99%(Assaybytitration,HPLC) 99%(Assaybytitration,HPLC) | 6106-46-3 | 1G | $72.8 | 2021-12-16 | Buy |
| Chem-Impex | 32523 | Scopolaminemethylnitrate,≥99%(Assaybytitration,HPLC)Hazmat ≥99%(Assaybytitration,HPLC) | 6106-46-3 | 5G | $262.08 | 2021-12-16 | Buy |
SCOPOLAMINE METHYL NITRATE Chemical Properties,Uses,Production
Originator
Transderm ,Scop Novartis Consumer Health Inc.
Uses
(-)Scopolamine Methylnitrate is a competitive antimuscarinic agent.
Manufacturing Process
In a one-liter separatory funnel, 94 g (0.215 mol) of scopolamine hydrobromide trihydrate was dissolved in 250 ml of water, made alkaline by shaking with 40 g (1 mol) of sodium hydroxide in 150 ml of water, and the free base immediately extracted with ether. As scopolamine is somewhat soluble in water, the aqueous layer was saturated with potassium carbonate and again extracted with ether. The combined ether extracts were dried over anhydrous magnesium sulfate and the ether removed by distillation, leaving 65 g (0.214 mol; 100% yield) of nearly colorless oil. Then 100 g (1.05 mol) of cold methyl bromide was added to a chilled, 500-ml pressure flask containing the 65 g of scopolamine, the flask stoppered tightly with a clamp, and allowed to stand at room temperature for 96 hours. The flask was cooled before opening, excess methyl bromide removed by distilling, and the white solid washed thoroughly with dry ether. The yield of crude Nmethylscopolammonium bromide was 80 g (94 %t yield). The salt was recrystallized from 550 ml of alcohol; first crop, 70 g, MP: 212-214°C; second crop, 6 g, melting point 195-200°C. The combined crops were again recrystallized from 500 ml of alcohol; melting point 210-212°C. The third recrystallization from 600 ml of alcohol yielded 64 g, melting point 214- 216°C, a 75 % yield based on scopolamine hydro-bromide trihydrate starting material. N-Methylscopolammonium bromide may be dissolved in water. An equivalent of solution AgNO3 was added, a precipitated AgBr was filtered off. The filtrate was evaporated to dryness to give the desired Nmethylscopolammonium nitrate.
brand name
Mesconit;Skopyle.
Therapeutic Function
Anticholinergic, Spasmolytic
World Health Organization (WHO)
Hyoscine methonitrate, a quaternary ammonium anticholinergic agent, was introduced in 1947 for use as a gastrointestinal antispasmodic. The action taken in Sweden relates to the use of this compound in preparations for suppressing the appetite. Preparations may remain available elsewhere.
SCOPOLAMINE METHYL NITRATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
| Aston Chemical | 13000000000 | sales@astonchem.com | United States | 1634 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Supplier | Advantage |
|---|---|
| Chongqing Chemdad Co., Ltd | 58 |
| Antai Fine Chemical Technology Co.,Limited | 58 |
| Career Henan Chemica Co | 58 |
| AFINE CHEMICALS LIMITED | 58 |
| Alfa Chemistry | 58 |
| Aston Chemical | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| Mainchem Co., Ltd. | 55 |
| J & K SCIENTIFIC LTD. | 76 |
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