ChemicalBook >> CAS DataBase List >>(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM

CAS No.
127299-93-8
Chemical Name:
(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM
Synonyms
BRL 37344A;BRL 37344 SODIUM;BRL 37344 Na Salt;BRL 37344 SODIUM SALT;BRL 37344 hydrate sodium salt;(R,R)-(+/-)-4-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxyaceticacid;(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM;(R*,R*)-(+/-)-4-[2-[(2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO]PROPYL]PHENOXYACETIC ACID, SODIUM SALT;(±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate;Acetic acid, 2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-, sodium salt (1:1), rel-
CBNumber:
CB2675428
Molecular Formula:
C19H23ClNNaO4
Molecular Weight:
387.84
MDL Number:
MFCD09971030
MOL File:
127299-93-8.mol
Last updated:2023-06-30 15:45:59

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Properties

storage temp. Store at RT
solubility H2O: 10 mg/mL
form powder
color white
Water Solubility Soluble to 100 mM in water
FDA UNII H7P384313Z

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B169 BRL 37344 sodium salt hydrate solid 127299-93-8 5mg $134 2024-03-01 Buy
Sigma-Aldrich B169 BRL 37344 sodium salt hydrate solid 127299-93-8 25mg $293.4 2024-03-01 Buy
Cayman Chemical 18622 BRL 37344 (sodium salt) ≥98% 127299-93-8 1mg $49 2024-03-01 Buy
Cayman Chemical 18622 BRL 37344 (sodium salt) ≥98% 127299-93-8 5mg $120 2024-03-01 Buy
Cayman Chemical 18622 BRL 37344 (sodium salt) ≥98% 127299-93-8 10mg $216 2024-03-01 Buy
Product number Packaging Price Buy
B169 5mg $134 Buy
B169 25mg $293.4 Buy
18622 1mg $49 Buy
18622 5mg $120 Buy
18622 10mg $216 Buy

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Chemical Properties,Uses,Production

Uses

BRL 37344 Sodium is a potent and selective b3-AR agonist.

Biological Activity

Potent and selective β 3 adrenoceptor agonist (K i values are 287, 1750 and 1120 nM for β 3 , β 1 and β 2 receptors respectively). Also available as part of the β -Adrenoceptor Agonist Tocriset™ .

Biochem/physiol Actions

BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.

storage

Store at RT

References

[1]. simard pm, atgié c, mauriège p, et al. comparison of the lipolytic effects of norepinephrine and brl 37344 in rat brown and white adipocytes. obes res, 1994, 2(5): 424-431.
[2]. kozlovski vi, chlopicki s, gryglewski rj. effects of two beta3-agonists, cgp 12177a and brl 37344, on coronary flow and contractility in isolated guinea pig heart. j cardiovasc pharmacol, 2003, 41(5): 706-713.
[3]. reverte m, rivas-cabañero l. effects of the beta 3-adrenoceptor agonist brl 37344 on lipomobilization and plasma glucose levels in conscious fasted rabbits. can j physiol pharmacol, 1996, 74(3): 251-256.
[4]. kasahara h, muto s, motokawa y, et al. β3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist brl 37344. j toxicol sci, 2010, 35(5): 779-784.

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM Suppliers

Global( 27)Suppliers
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TargetMol Chemicals Inc.
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223 psaitong@jm-bio.com China 29834 58
(+/-)-(R*,R*)-[4-[2-[[2-(3-CHLOROPHENYL)-2-HYDROXYETHYL] AMINO]PROPYL]PHENOXY]-ACETIC ACID SODIUM (R*,R*)-(+/-)-4-[2-[(2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO]PROPYL]PHENOXYACETIC ACID, SODIUM SALT (±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate BRL 37344 Na Salt BRL 37344A BRL 37344 SODIUM BRL 37344 SODIUM SALT (R,R)-(+/-)-4-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxyaceticacid BRL 37344 hydrate sodium salt BRL 37344A, (±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate Acetic acid, 2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-, sodium salt (1:1), rel- 127299-93-8 C19H21NO4ClNa C19H21ClNNaO4 C19H21ClNNaO4xH2O Adrenoceptor