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Difluoroacetic acid

Difluoroacetic acid structure

CAS No.: 381-73-7

Chemical Name:: Difluoroacetic acid

Synonyms: 2,2-DIFLUOROACETIC ACID;DIFLUOROACETATE;ifluoroaceticaci;VITAS-BB TBB000649;difluoro-aceticaci;DIFLUOROACETIC ACID;Difluoroaceticacid98%;Acetic acid, difluoro-;1,1-DIFLUOROACETIC ACID;Twotrifluoroacetic acid

CBNumber:: CB2700577

Molecular Formula:: C2H2F2O2

Molecular Weight:: 96.03

MDL Number:: MFCD00004220

MOL File:: 381-73-7.mol

MSDS File:: SDS

Last updated:2023-11-08 17:00:29

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Difluoroacetic acid Properties

Melting point	-1 °C (lit.)
Boiling point	132-134 °C (lit.)
Density	1.526 g/mL at 25 °C (lit.)
vapor pressure	11.7hPa at 25℃
refractive index	n20/D 1.344(lit.)
Flash point	174 °F
storage temp.	2-8°C
solubility	540.54g/L in organic solvents at 20 ℃
form	Liquid
pka	pK1:1.33 (25°C)
Specific Gravity	1.527 (20℃)
color	Clear colorless to light brown
Water Solubility	1000g/L at 37℃
BRN	1098588
InChIKey	PBWZKZYHONABLN-UHFFFAOYSA-N
LogP	0.601 at 37℃
CAS DataBase Reference	381-73-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	ZQK1C95K3N
NIST Chemistry Reference	Difluoroacetic acid(381-73-7)
EPA Substance Registry System	Acetic acid, difluoro- (381-73-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H314-H332-H412

Precautionary statements

P261-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

Risk Statements

34-35

Safety Statements

26-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

RTECS

AG9900000

Hazard Note

Corrosive

TSCA

HazardClass

PackingGroup

HS Code

29159080

NFPA 704

	2
3		0

Difluoroacetic acid price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	142859	Difluoroacetic acid 98%	381-73-7	5g	$78.8	2024-03-01	Buy
Sigma-Aldrich	142859	Difluoroacetic acid 98%	381-73-7	25g	$191	2024-03-01	Buy
Sigma-Aldrich	00922	Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC)	381-73-7	10X1ML	$252	2022-05-15	Buy
Sigma-Aldrich	00922	Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC)	381-73-7	50ML	$802	2022-05-15	Buy
TCI Chemical	D1423	Difluoroacetic Acid >97.0%(T)	381-73-7	5g	$50	2024-03-01	Buy

Product number	Packaging	Price	Buy
142859	5g	$78.8	Buy
142859	25g	$191	Buy
00922	10X1ML	$252	Buy
00922	50ML	$802	Buy
D1423	5g	$50	Buy

Difluoroacetic acid Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light brown liquid

Uses

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.

Flammability and Explosibility

Non flammable

Purification Methods

Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]

Difluoroacetic acid synthesis

Synthesis of Difluoroacetic acid from Ethyl difluoroacetate and Trifluoroacetic acid

Difluoroacetic acid Preparation Products And Raw materials

Raw materials

CHLORODIFLUOROACETYL CHLORIDE Chlorodifluoroacetic acid METHYL CHLORODIFLUOROACETATE METHYL DIFLUOROACETATE Methanol

Preparation Products

BROMODIFLUOROACETIC ACID TETRAFLUOROSUCCINIC ACID 2-Difluoromethyl-1H-benzoimidazole 1-Benzyl-2-(difluoroMethyl)-4,5-dihydro-1H-iMidazole 2-(DifluoroMethyl)-1-phenyl-4,5-dihydro-1H-iMidazole

3-Buten-2-one, 4-ethoxy-1,1-difluoro-, (3E)-

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Difluoroacetic acid Suppliers

Global( 347)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58

Supplier	Advantage
CD Chemical Group Limited	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Hebei Guanlang Biotechnology Co., Ltd.	58

View Lastest Price from Difluoroacetic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-02	Difluoroacetic acid 381-73-7	US $90.00-900.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2023-04-12	Difluoroacetic Acid 381-73-7	US $0.00 / L	200L	99%	1000MT	Hefei TNJ Chemical Industry Co.,Ltd.
2023-03-11	Difluoroacetic acid 381-73-7	US $0.00 / kg	1kg	98.0%min	1000kg	LY Global chemicals co.,ltd .

Difluoroacetic acid
381-73-7
US $90.00-900.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Difluoroacetic Acid
381-73-7
US $0.00 / L
99%
Hefei TNJ Chemical Industry Co.,Ltd.

Difluoroacetic acid
381-73-7
US $0.00 / kg
98.0%min
LY Global chemicals co.,ltd .

Difluoroacetic acid Spectrum

Difluoroacetic acid(381-73-7)MS Difluoroacetic acid(381-73-7)¹HNMR Difluoroacetic acid(381-73-7)¹³CNMR Difluoroacetic acid(381-73-7)IR1 Difluoroacetic acid(381-73-7)Raman

381-73-7(Difluoroacetic acid)Related Search:

Ethyl 2-(Chlorosulfonyl)acetate 2-Bromo-2,2-difluoroacetic acid ethyl ester Glycine Folic acid Trifluoroacetic acid

Trifluoroacetic anhydride DIFLUOROACETIC ACID ETHYL ESTER,ETHYL DIFLUOROACETIC ACID Fluroxypyr DIFLUOROACETIC ACID METHYL ESTER,α,2-Difluoroacetic acid methyl ester Ethyl trifluoroacetate

Citric acid Chlorodifluoroacetic acid ethyl ester Sodium chlorodifluoroacetate Diethyl 2,2-difluoromalonate Ascoric Acid

DIFLUOROACETIC ACID ANHYDRIDE TRIMETHYLSILYL TRIFLUOROACETATE THALLIUM(III) TRIFLUOROACETATE

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1,1-DIFLUOROACETIC ACID VITAS-BB TBB000649 DIFLUOROACETIC ACID Acetic acid, difluoro- difluoro-aceticaci Difluoroaceticacid98% Difluoroacetic acid, 98% 10ML Difluoroacetic acid, 98% 2.5ML 2,2-Difluoroethanoic acid Twotrifluoroacetic acid Aceticacid, 2,2-difluoro- Difluoroacetic acid, 97%+ Difluoroacetic Acid > ifluoroaceticaci DIFLUOROACETATE 2,2-DIFLUOROACETIC ACID 381-73-7 7381-73-7 F2CHCO2H F2CHCOOH CHF2COOH C2H2F2O2 CARBOXYLIC ACID Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Fluorinated Building Blocks Synthetic Reagents Organic Acids Pharmaceutical Intermediates Small molecule Organic Fluorides Fluorinated Building Blocks Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Synthetic Organic Chemistry Chemical Synthesis Organic Acids Synthetic Reagents