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Rhodamine 123

CAS No.
62669-70-9
Chemical Name:
Rhodamine 123
Synonyms
rh123;R 302;R 22420;RHODAMINE 123;-Cellstain-Rh123;Rhodamine 123 ,98%;Rhodamine 123, 99+%;Rhodamine 123, pure;Rhodamine 123 (RH-123;Rhodamine 123 Chloride
CBNumber:
CB2702364
Molecular Formula:
C21H17ClN2O3
Molecular Weight:
380.83
MDL Number:
MFCD00012664
MOL File:
62669-70-9.mol
Last updated:2023-09-28 17:55:30

Rhodamine 123 Properties

Melting point 235 °C
Density 1.2224 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility ethanol: 20 mg/mL, clear, red
form Powder
color Red-brown to brown or dark green
Water Solubility Partially soluble
λmax 501 nm, 507 nm
BRN 6030951
Stability Hygroscopic
Major Application Colored bubbles; color filters; liquid crystal displays; light-emitting diodes; luminescent materials;nanophotonic composites; paints; semiconductor electrodes;solar cells
Biological Applications Measuring membrane potential; detecting cancer cells,spores,prostate cancer,stress biomarkers; treating disc degenerative disease,epilepsy,erectile dysfunction; apoptosis assays; tumor cell multidrug resistance assay; implantable
InChIKey MYFATKRONKHHQL-UHFFFAOYSA-N
CAS DataBase Reference 62669-70-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 1N3CZ14C5O
EPA Substance Registry System Xanthylium, 3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-, chloride (62669-70-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25
WGK Germany  3
RTECS  ZE0883000
HS Code  32049010
NFPA 704
0
2 0

Rhodamine 123 price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R8004 Rhodamine 123 mitochondrial specific fluorescent dye 62669-70-9 5mg $39.5 2024-03-01 Buy
Sigma-Aldrich R8004 Rhodamine 123 mitochondrial specific fluorescent dye 62669-70-9 25mg $153 2024-03-01 Buy
Cayman Chemical 16672 Rhodamine 123 (chloride) ≥95% 62669-70-9 5mg $32 2024-03-01 Buy
Cayman Chemical 16672 Rhodamine 123 (chloride) ≥95% 62669-70-9 10mg $57 2024-03-01 Buy
Sigma-Aldrich R8004 Rhodamine 123 mitochondrial specific fluorescent dye 62669-70-9 100mg $429 2024-03-01 Buy
Product number Packaging Price Buy
R8004 5mg $39.5 Buy
R8004 25mg $153 Buy
16672 5mg $32 Buy
16672 10mg $57 Buy
R8004 100mg $429 Buy

Rhodamine 123 Chemical Properties,Uses,Production

Description

Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells. It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp. As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells. Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation. Rhodamine 123 has excitation/emission maxima of 507/529 nm.

Chemical Properties

red-brown to brown or dark green powder

Uses

Rhodamine-123 lycoprotein (P-gp) functional efflux activity in vivo. Rhodamine-123 PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid).

Uses

Useful as a laser dye and to have selective cell growth effects. Mitochondrial specific fluorescent dye and substrate for P-glycoprotein.

Uses

Rhodamine derivative, a fluoresent dye-labeled compound.

Uses

Fluorescent dye most commonly used as functional reporter in flow cytometry.

Uses

Rhodamine-123 is a fluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Rhodamine 123 (R123), as a typical of P-glycoprotein substrate, was widely used to quantify P-glycoprotein (P-gp) functional efflux activity in vivo. Rhodamine-123 can be used in multiparameter analyses without fluorescence interference in combination with common protein labeling dyes such as PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid).

in vitro

rhodamine 123, which was identified as a member of the rhodamine family of flurone dyes, was used to examine membrane transport by the abcb1 gene product, mdr1. previous study determined the λmax for excitation and emission for rhodamine 123 in commonly used solvents and extraction buffers, indicating that the fluorescence of rhodamine 123 was highly dependent on the chemical environment. the optimal parameters are 1% methanol in hbss. in addition, the uptake of rhodamine 123 into cells was via both passive and active processes, and this occurred mainly by oatp1a2-mediated transport. furthermore, this previous study quantified the intracellular sequestration and metabolism of rhodamine 123, showing that these were both cell line-dependent factors that might influence the interpretation of transport assays [1].

References

[1] samantha forster et al. characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays. plos one. 2012; 7(3): e33253.

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View Lastest Price from Rhodamine 123 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rhodamine 123 pictures 2023-09-28 Rhodamine 123
62669-70-9
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Rhodamine 123 pictures 2019-07-06 Rhodamine 123
62669-70-9
US $1.00 / kg 1kg 95%-99% 1000kg Career Henan Chemical Co
  • Rhodamine 123 pictures
  • Rhodamine 123
    62669-70-9
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Rhodamine 123 pictures
  • Rhodamine 123
    62669-70-9
  • US $1.00 / kg
  • 95%-99%
  • Career Henan Chemical Co

Rhodamine 123 Spectrum

Rhodamine methyl ester hydrochloride Rhodamin 123 Chloride, laser grade 2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester monohydrochloride Benzoic acid, 2-(6-amino-3-imino-3H-xanthen-9-yl)-, methyl ester, monohydrochloride Xanthylium, 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)-, chloride Rhodamine 123 ,98% RHODAMINE 123, 99+%, PURE Rhodamine 123, pure Rhodamine 123,2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester RhodaMine 123 Chloride, Laser Grade Rhodamine 123, 99+% 2-[6-AMINO-3-IMINO-3H-XANTHEN-9-YL]BENZOIC ACID METHYL ESTER 2-(6-AMINO-3-IMINO-3H-XANTHEN-9-YL)BENZOIC ACID METHYL ESTER CHLORIDE RHODAMINE METHYL ESTER CHLORIDE R 22420 R 302 Rhodamine 123 Chloride RHODAMINE 123, FOR FLUORESCENCE -Cellstain-Rh123 Rhodamine 123, pure, 99+% RHODAMINE 123 RHODAMINE 123 HYDROCHLORIDE 2-(6-amino-3-imino-3h-xanthen-9-yl)benzoicacidmethylestermonohydrochlorid 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)-xanthyliuchloride 3,6-diamino-9-(2-(methoxycarbonyl)phenyl)xanthyliumchloride benzoicacid,2-(6-amino-3-imino-3h-xanthen-9-yl)-,methylester,monohydroch Rhodamine 123 *CAS 62669-70-9* Rhodamine 123 (RH-123 rh123 62669-70-9 C21H17N2O3Cl C28H24N4O10S C21H16N2O3HCl C21H17ClN2O3 Fluorescent Probes, Labels, Particles and Stains Fluorescent Indicators and Probes Alphabetical Lipophilic and Membrane Probes Biochemicals and Reagents BioChemical Xanthene Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Fluorescent Labels & Indicators ROX