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Fluvoxamine maleate

CAS No.
61718-82-9
Chemical Name:
Fluvoxamine maleate
Synonyms
Fluvoxamine for system suitability CRS;Luvox;MK-264;du23000;Dumirox;Faverin;Fevarin;Maveral;faverin50;Floxyfral
CBNumber:
CB2722966
Molecular Formula:
C19H25F3N2O6
Molecular Weight:
434.41
MDL Number:
MFCD00269809
MOL File:
61718-82-9.mol
MSDS File:
SDS
Last updated:2024-03-16 07:03:48

Fluvoxamine maleate Properties

Melting point 120-121.5 °C
Flash point 9℃
storage temp. 2-8°C
solubility H2O: soluble
form solid
color White to Off-White
Water Solubility Soluble in water (10mM)
Merck 14,4219
BCS Class 1
InChIKey LFMYNZPAVPMEGP-PIDGMYBPSA-N
SMILES C(C1C=CC(=CC=1)/C(=N\OCCN)/CCCCOC)(F)(F)F.C(O)(=O)/C=C\C(O)=O
CAS DataBase Reference 61718-82-9(CAS DataBase Reference)
NCI Dictionary of Cancer Terms Luvox
FDA UNII 5LGN83G74V
NCI Drug Dictionary fluvoxamine maleate

Pharmacokinetic data

Protein binding 80%
Excreted unchanged in urine 2%
Volume of distribution 25
Biological half-life 13-15 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  36-36/37/39-27-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  SA9230000
HS Code  29280000
NFPA 704
0
3 0

Fluvoxamine maleate price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F-040 Fluvoxamine maleate 1.0?mg/mL in methanol (as free base), certified reference material, Cerilliant? 61718-82-9 1mL $92.8 2024-03-01 Buy
Sigma-Aldrich BP671 Fluvoxamine maleate impurity standard British Pharmacopoeia (BP) Reference Standard 61718-82-9 100MG $266 2024-03-01 Buy
Sigma-Aldrich BP600 Fluvoxamine maleate British Pharmacopoeia (BP) Reference Standard 61718-82-9 100MG $223 2024-03-01 Buy
Sigma-Aldrich 1285909 Fluvoxamine maleate United States Pharmacopeia (USP) Reference Standard 61718-82-9 200mg $1200 2024-03-01 Buy
TCI Chemical F0858 Fluvoxamine Maleate >98.0%(HPLC)(T) 61718-82-9 1g $115 2024-03-01 Buy
Product number Packaging Price Buy
F-040 1mL $92.8 Buy
BP671 100MG $266 Buy
BP600 100MG $223 Buy
1285909 200mg $1200 Buy
F0858 1g $115 Buy

Fluvoxamine maleate Chemical Properties,Uses,Production

Description

Fluvoxamine maleate is the most recent of the serotonin-specific antidepressants to reach the market. In vitro and in vivo animal experiments have shown fluvoxamine to have a marked effect on 5-HT mediated processes and little effect on norepinephrine. Clinical trials suggest similar efficacy to imipramine and clomipramine with a somewhat lower incidence of side effects, especially anticholinergic effects. Fluvoxamine, in contrast to the tricyclic antidepressants, does not appear to produce heart rate increase, postural hypotension or prolongation of the intraventricular conduction time and QT interval.

Chemical Properties

Crystalline Solid

Originator

Duphar (Netherlands)

Uses

Fluvoxamine maleate has been used as a test compound to determine the solubility and effective blood-brain barrier permeability.(2)

Uses

Anxiety disorder

Uses

nonsteroidal anti-inflammatory reduces pain and inflammation in eyes

Uses

A selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.

Uses

estrogen

Definition

ChEBI: Fluvoxamine maleate is a member of (trifluoromethyl)benzenes.

Manufacturing Process

20.4 mmol (5.3 g) of 5-methoxy-4'-trifluoromethylvalerophenone (MP 43°C to 44°C), 20.5 mmol (3.1 g) of 2-aminooxyethylamine dihydrochloride and 10 ml of pyridine were refluxed for 15 hr in 20 ml of absolute ethanol. After evaporating the pyridine and the ethanol in vacuo, the residue was dissolved in water. This solution was washed with petroleum ether and 10 ml of 50% sodium hydroxide solution were then added. Then three extractions with 40 ml of ether were carried out. The ether extract was washed successively with 20 ml of 5% sodium bicarbonate solution and 20 ml of water. After drying on sodium sulfate, the ether layer was evaporated in vacuo. Toluene was then evaporated another three times (to remove the pyridine) and the oil thus obtained was dissolved in 15 ml of absolute ethanol. An equimolar quantity of maleic acid was added to the solution and the solution was then heated until a clear solution was obtained. The ethanol was then removed in vacuo and the residue was crystallized from 10 ml of acetonitrile at +5°C. After sucking off and washing with cold acetonitrile, it was dried in air. The MP of the resulting compound was 120°C to 121.5°C.

brand name

Luvox (Solvay Pharmaceuticals);FLOXYFRAL.

Therapeutic Function

Antidepressant

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Hazard

A poison by ingestion. Human systemic effects.

Biological Activity

Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a K i of 1.6 nmol/l. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .

Biochem/physiol Actions

Fluvoxamine maleate is a selective neuronal serotonin reuptake inhibitor. It functions as an antidepressant and anti-obsessive agent. It is useful in treating obsessive compulsive disorder and panic disorder.

Clinical Use

SSRI antidepressant:
Depression
Obsessive compulsive disorder

Veterinary Drugs and Treatments

Fluvoxamine may be considered for use in treating a variety of behavior- related diagnoses in dogs and cats, including aggression and stereotypic behaviors (and other obsessive-compulsive behaviors).

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: increased aminophylline and theophylline concentrations - avoid; if not possible, halve aminophylline or theophylline dose and monitor levels.
Analgesics: increased risk of bleeding with aspirin and NSAIDs; risk of CNS toxicity increased with tramadol; concentration of methadone possibly increased.
Anti-arrhythmics: increased risk of toxicity with mexiletine.
Anticoagulants: effect of coumarins possibly enhanced; possibly increased risk of bleeding with dabigatran.
Antidepressants: avoid with reboxetine, MAOIs, moclobemide and St John’s wort; possibly enhanced serotonergic effects with mirtazapine; fluvoxamine inhibits metabolism of duloxetine - avoid; can increase tricyclics concentration; metabolism of agomelatine reduced; possible increased risk of convulsions with vortioxetine.
Antiepileptics: antagonise anticonvulsant threshold; concentration of carbamazepine, fosphenytoin and phenytoin increased.
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: concentration of asenapine, haloperidol, clozapine and olanzapine increased; increased risk of ventricular arrhythmias with droperidol and possibly pimozide - avoid.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: may increase ciclosporin concentration.
Clopidogrel: possibly reduced antiplatelet effect.
Cytotoxics: concentration of pomalidomide increased
Dapoxetine: possible increased risk of serotonergic effects - avoid.
Dopaminergics: increased risk of CNS toxicity with rasagiline - avoid; hypertension and CNS excitation with selegiline - avoid.
5HT1 agonists: risk of CNS toxicity increased with sumatriptan; possibly increased risk of serotonergic effects with naratriptan; inhibits metabolism of frovatriptan; possibly inhibits metabolism of zolmitriptan - reduce zolmitriptan dose.
Linezolid: use with care, possibly increased risk of side effects.
Lithium: increased risk of CNS effects - monitor levels.
Melatonin: concentration of melatonin increased - avoid.
Methylthioninium: risk of CNS toxicity - avoid if possible.
Muscle relaxants: increased risk of toxicity with tizanidine - avoid
Pirfenidone: concentration of pirfenidone increased - avoid.

Metabolism

Fluvoxamine undergoes extensive hepatic transformation by CYP2D6, mainly via oxidative demethylation, into at least 9 metabolites. The 2 major metabolites showed negligible pharmacological activity. The other metabolites are not expected to be pharmacologically active.
Excretion is mainly in the urine; about 2% of a dose is excreted as unchanged drug.

storage

+4°C (desiccate)

61718-80-7
870-24-6
110-16-7
61718-82-9
Synthesis of Fluvoxamine maleate from 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone and 2-Chloroethylamine hydrochloride and Maleic acid

Fluvoxamine maleate Preparation Products And Raw materials

Global( 409)Suppliers
Supplier Tel Email Country ProdList Advantage
Jewim Pharmaceutical (Shandong) Co., Ltd.
+86-15552509998 +86-15621883869 liutf@jewim.com.cn China 251 58
Zhuhai Hairuide Bioscience and Technology Co., Ltd
+8618928027945 sales3@zhhairuide.com China 97 58
Zibo Wei Bin Import & Export Trade Co. Ltd.
+86-0533-2091136 +8613864437655 ziboweibinmaoyi@163.com China 100 58
Hong Kong Excellence Biotechnology Co., Ltd.
+86-86-18838029171 +8618126314766 ada@sh-teruiop.com China 892 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11001 58
Sigma Audley
+86-18336680971 +86-18126314766 nova@sh-teruiop.com China 524 58
Shanghai Aosiris new Material Technology Co., LTD
+8617513190836 wrjmoon2000@163.com China 278 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998 sales@czwytech.com CHINA 906 58

View Lastest Price from Fluvoxamine maleate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fluvoxamine maleate pictures 2024-03-29 Fluvoxamine maleate
61718-82-9
US $100.00 / kg 1kg 99% 1t Zibo Wei Bin Import & Export Trade Co. Ltd.
Fluvoxamine maleate pictures 2024-03-22 Fluvoxamine maleate
61718-82-9
US $100.00 / kg 1kg 99.9% 20tons Hong Kong Excellence Biotechnology Co., Ltd.
Fluvoxamine maleate pictures 2024-03-16 Fluvoxamine maleate
61718-82-9
US $35.00-25.00 / kg 1kg 99.8% 200tons/year Sigma Audley

Fluvoxamine maleate Spectrum

FLUVOXAMINE MALEATE (E)-5-METHOXY-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-PENTANONE-O-(2-AMINOETHYL)OXIME MALEATE 1-pentanone,5-methoxy-1-(4-(trifluoromethyl)phenyl)-,o-(2-aminoethyl)oxime,( 5-methoxy-4’-trifluoromethylvalerophenone(e)-o-2-aminoethyloximemonomaleate du23000 faverin50 (E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-O-(2-aminoethyl)oxime-1-pentanone Fluvoxamine maleate,(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate Fluvoxamine Maleate (200 mg) (E)-5-Methoxy-1-(4-(trifluoroMethyl)phenyl)pentan-1-one O-(2-aMinoethyl) oxiMe Maleate (E)-5-Methoxy-1-[4-(trifluoroMethyl)]-1-pentanone-O-(2-aMinoehyl)oxiMe Maleate 2-[[5-Methoxy-1-[4-(trifluoromethyl)phenyl]-pentylidene]amino]oxyethanamine maleate MK-264, DI-23000, Dumirox, Flaverrin, Fevarin, Floxyfral, Luvox, Maveral, (E)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone, Maleate, (E)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one O-2-aminoethyl oxime 1-Pentanone, 5-methoxy-1-4-(trifluoromethyl)phenyl-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate (1:1) Fluvoxamine Maleat (E)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime Maleate Dumirox Faverin Fevarin Floxyfral Luvox Maveral MK-264 (E)-Fluvoxamine Maleate FluvoxaMine Meleate 1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate Fluvoxamine maleate, 98%, a selective serotonin (5-HT) reuptake inhibitor (SSRI) FluvoxamineMaleate> Fluvoxamine Maleate RS Fluvoxamine maleate CRS DU-23000 (maleate) Fluvoxamine maleate USP/EP/BP Fluvoxamine maleate (DU23000 maleate) Fluvoxamine D4 MaleateQ: What is Fluvoxamine D4 Maleate Q: What is the CAS Number of Fluvoxamine D4 Maleate Q: What is the storage condition of Fluvoxamine D4 Maleate Q: What are the applications of Fluvoxamine D4 Maleate Fluvoxamine maleateQ: What is Fluvoxamine maleate Q: What is the CAS Number of Fluvoxamine maleate Q: What is the storage condition of Fluvoxamine maleate Q: What are the applications of Fluvoxamine maleate "Fluvoxamine Maleate 13C, D3" Fluvoxamine Maleate (1285909) Fluvoxamine for system suitability CRS FLUVOXAMINE MALEATE IP/BP/USP 61718-82-9 61718-82-8 61717-82-9 C15H21F3N2O2C4H4O C19H25F3N2O6 C14H18F3N2O2C4H4O4 ESTROVIS Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals Serotonin receptor 61718-82-9