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Gentamicin sulfate

CAS No.
1405-41-0
Chemical Name:
Gentamicin sulfate
Synonyms
GENTAMICIN SULPHATE STERILE;Gentak;U-gencin;GENTAMICIN 2,5-SULFATE HYDRATE;100ppm;Apogen;Pangram;sch9724;Garacin;Gentalin
CBNumber:
CB2733991
Molecular Formula:
C60H127N15O26S
Molecular Weight:
1506.8
MDL Number:
MFCD00270181
MOL File:
1405-41-0.mol
Last updated:2023-12-13 16:54:32

Gentamicin sulfate Properties

Melting point 218-237°C
alpha D25 +102°
Density 1.000 g/cm3
storage temp. 2-8°C
solubility H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days.
form powder
color colorless to light yellow
PH 4.0-5.5 (0.1g/mL in H2O)
Odor odorless
optical activity [α]20/D +110±8°, c = 1% in H2O
Water Solubility Soluble in water
Merck 13,4403
InChIKey RDEIXVOBVLKYNT-HDZPSJEVSA-N
CAS DataBase Reference 1405-41-0(CAS DataBase Reference)
FDA UNII 8X7386QRLV
EPA Substance Registry System Gentamicin sulfate (1405-41-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P333+P313
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  23-36/37-45-22-24/25
WGK Germany  2
RTECS  LY2625000
3
HS Code  29419010
Toxicity LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black)
NFPA 704
0
2 0

Gentamicin sulfate price More Price(77)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 48760 Gentamicin sulfate from Micromonospora purpurea ≥590?μg/mg of gentamicin 1405-41-0 1g $120 2024-03-01 Buy
Sigma-Aldrich BP174 Gentamicin sulfate British Pharmacopoeia (BP) Reference Standard 1405-41-0 25MG $229 2024-03-01 Buy
Sigma-Aldrich 48760 Gentamicin sulfate from Micromonospora purpurea ≥590?μg/mg of gentamicin 1405-41-0 5G $369 2024-03-01 Buy
Sigma-Aldrich 48760 Gentamicin sulfate from Micromonospora purpurea ≥590?μg/mg of gentamicin 1405-41-0 25g $1290 2024-03-01 Buy
Sigma-Aldrich 345814-M Gentamycin Sulfate - CAS 1405-41-0 - Calbiochem Broad-spectrum cell culture antibiotic that is nontoxic to viruses and mammalian cells at antibacterial and antimycoplasmal concentrations. 1405-41-0 1g $95.8 2024-03-01 Buy
Product number Packaging Price Buy
48760 1g $120 Buy
BP174 25MG $229 Buy
48760 5G $369 Buy
48760 25g $1290 Buy
345814-M 1g $95.8 Buy

Gentamicin sulfate Chemical Properties,Uses,Production

Chemical Properties

White to buff-colored powder, hygroscopic, easily soluble in water, insoluble in lipids, insoluble in organic solvents, stable in chemical properties, relatively stable to changes in temperature and pH, the pH of 4% aqueous solution is 4.0-6.0. There are five basic centers in the gentamicin molecule, which is a basic compound, and the drug is the sulfate of gentamicin. Gentamicin is a complex of C components, the main components of which are C1, C2, C1a, and C2a.

Originator

Garamycin,Schering,US,1966

Uses

This compound is a complex mixture of the sulfates of gentamycin Cl, gentamycin CIA and gentamycin C2. Pharmaceutical incompatibilites include amphotericin, cephalosporins, erythromycin, heparin, penicillins, sodium bicarbonate, and sulfadiazine sodium. It is used as topical and systemic broad-spectrum antibiotic with bactericidal action; also used in ophthalmic drugs.

Uses

Gentamicin sulfate is an aminoglycoside antibiotic. Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial. Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the complex but is similar to Kanamycin C. Gentamicin C1: R1=R2=CH3 Gentamicin C2: R1=CH3; R2=H Gentamicin C1A: R1=R2=H.

Manufacturing Process

Germination Stage: A lyophilized culture of M. purpurea is added to a 300 ml shake flask containing 100 ml of the following sterile medium: 3 grams bactobeef extract; 5 grams tryptose; 1 gram dextrose; 24 grams starch (soluble); 5 grams yeast extract; and 1,000 ml tap water. The flask and its contents are incubated for 5 days at 37°C on a rotary shaker (280 rpm, 2 inch stroke).
Inoculum Preparation Stage: Two batches of inoculum of about 50 gallons each are prepared by the following method: A 25 ml inoculum (from the germination stage) is transferred to each of four 2-liter flasks, each containing 500 ml of the sterile medium utilized for germination. The flasks and contents are incubated for 5 days at 28°C on a rotary shaker (280 rpm, 2 inch stroke).
The contents of the flasks are pooled, a 25 ml inoculum (taken from the pool) is added to each of twenty 2-liter flasks, each containing 500 ml of the following sterile medium: 30 grams soybean meal; 40 grams dextrose (cerelose); 1 gram calcium carbonate; 1,000 milliliters tap water. The flasks and their contents are incubated for 3 to 5 days at 28°C on a rotary shaker (280 rpm, 2 inch stroke). The broth is pooled and aseptically transferred into a sterile inoculum flask having a side arm (total volume, about 10 liters).
The 10 liters of inoculum is aseptically transferred to a 65-gallon fermenter containing 50 gallons of the following sterile medium: 600 grams bacto-beef extract; 1,000 grams bacto-tryptose; 200 grams dextrose (cerelose); 4,800 grams starch (soluble); 1,000 grams yeast extract; 100 ml antifoamer GE 60 (General Electric Co. brand of silicone defoamer), or other defoamer; and tap water, qs to 50 gallons.
The pH is adjusted to 6.9 to 7.0 before sterilization and aerobic fermentation is effected for 24 hours (until the packed cell volume is about 10 to 15%) under the following conditions: temperature, 37°C; sterile air input, 54 ft3/min; pressure, 7 psi; and agitation, 180 rpm.
Fermentation Stage: One 50-gallon batch of inoculum is aseptically transferred to a 675-gallon fermenter (fermenter A) containing the following medium: 54.0 kg soybean meal; 72.0 kg cerelose; 9.0 kg calcium carbonate; 300 ml antifoamer GE 60; and 450 gallons soft water. The other 50-gallon batch of inoculum is aseptically transferred to a similar fermenter (fermenter B) containing the same medium as fermenter A with the addition of 200 mg of CoCl2 · 6H2O. Fermentation is effected in each fermenter at 35°C while agitating at 120 rpm with air input at 7 psi and 15 ft3/min. At various times, samples of the fermented broth are withdrawn and assayed for antibiotic production by the disc assay method. The following table shows the increase in yield effected by the presence of cobalt, (as described in US Patent 3,136,704).
The conversion of the broth to gentamicin sulfate is described in US Patent 3,091,572.

brand name

Apogen (King); Garamycin (Schering); Genoptic (Allergan); Gentacidin (Novartis); Gentafair (Pharmafair); Gentak (Akorn); U-Gencin (Pharmacia & Upjohn).

Therapeutic Function

Antibacterial

General Description

Gentamicin sulfate is a sulfate salt of an antibiotic complex produced by fermentation of Micromonospora purpurea or M. echinospora. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base. Three closely related components that are chemically amino-saccharides. White to buff-colored powder. pH (4% solution) 3.5 to 5.5. Odorless.

Air & Water Reactions

Water soluble. Hygroscopic.

Reactivity Profile

Gentamycin sulfate is very stable in solution, even in moderately acidic to strongly basic aqueous media.

Fire Hazard

Flash point data for Gentamycin sulfate are not available; however, Gentamycin sulfate is probably combustible.

Biochem/physiol Actions

Mode of Action: Gentamicin inhibits protein synthesis by binding to the 30S subunit of the ribosome.Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Safety Profile

Poison by intravenous, intraperitoneal, and intramuscular routes. Moderately toxic by subcutaneous route. Human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx. See also other gentamycin entries.

storage

Store at +4°C

References

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO.J. 4 1. PMID: 10619838.
Casemore (1967) Gentamicin as a bactericidal agent in virological tissue cultures. J.Clin.Pathol. 20 298. PMID: 4972293
Martin, N.L., et al. Gentamicin interaction with Pseudomonas aeruginosa cell envelope. J. Comp. Neurol. 1986, 29(6), 1079-1087. DOI:10.1128/AAC.29.6.1079
Kadurugamuwa, J.L., et al. Surface action of gentamicin on Pseudomonas aeruginosa. J. Bacteriol. 1993, 175(18), 5798-805. DOI:10.1128/jb.175.18.5798-5805.1993

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View Lastest Price from Gentamicin sulfate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gentamycin sulfate pictures 2024-03-16 Gentamycin sulfate
1405-41-0
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Gentamycin sulfate pictures 2024-03-13 Gentamycin sulfate
1405-41-0
US $100.00 / kg 1kg 99 10t Zibo Wei Bin Import & Export Trade Co. Ltd.
Gentamycin Sulfate pictures 2024-03-12 Gentamycin Sulfate
1405-41-0
US $0.00 / g 1g 98% HPLC 1000kg shandong perfect biotechnology co.ltd
Gentamycin sulfate Gentamicin for peak identification Gentamicin sulfate solution,1000ppm Gentamicin sulfate solution,100ppm Gentamicin Sulfate, 500X Solution Gentamycin Sulfate/Micronomicin Sulfate Gentamycin sulfate, Antibiotic for Culture Media Use Only Gentamicin Sulfate Solution(10mg/ml) Gentamicin Sulfate Solution(50mg/ml) Gentamicin Sulfate, 100X Solution genoptics.o.p. gentalline gentamicinsolution nsc-82261 Gentalin Gentamycin, sulfate (salt) (8CI) Genticyn Gentrasul Geramycin Nichogencin Ophtagram Pangram Refobacin Refobacin 10 Refobacin L Septopal Sulmycin Urocydin Gentamycin Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested C complex sulfate GentamycinSulphateBp98 Gentamicin C complex sulfate GentamycinSulfate,Sterile-FilteredSolution,50mg/mlinDIWater GentamycinSulfate,USPGrade GentamycinSulfate,Sterile-FilteredSolution,10mg/mlinDIWater GENTAMICINSULFATE,CRYSTALLINEPOWDER,USP Dispagent gentamicin solution 10mg/ml sterile*filtered gentamicin solution cell culture tested gentamicin standard solution gentamicin sulfate cell culture tested gentamicin sulfate from micromonospora purpurea Gentamicin sulfate Micromonospora purpurea gentamicin sulfate solution hybri-max*50mg/ml Gentamicin sulfate, USP Grade +ENTAMICIN STANDARD SOLUTION GENTAMICIN SOLUTION FOR CELL BIOLOGY GENTAMICIN SULFATE PLANT CELL CULTURE*TE STED GENTAMICIN SULFATE, BIOTECHNOLOGY PERFOR GENTAMICIN SULFATE USP GENTAMICIN SULFATE GAMMA-IRRADIATED*MOLE CULAR BIOLO GENTAMICIN SULFATE USP GRADE 99% sch9724 Alcomicin, Bristagen, Cidomycin, Duragentam, Garamycin, Garasol,Genoptic, Gentacidin, Gentacin,Gentaglyde, Gentalyn, Gentamicin C Complex Citrate, Gentibioptal, Genticin, Gentocin, Gentogram, Gent-Ophtal, Getalline, GM sulfat Gentamicin Sulfate Salt (C Complex) PNGASE FROM ELIZABETHKINGIA (CHRYSEOBACTERIUM/FLAVOBACTERIUM) MENINGSEPTICUM O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1->4))-2-deoxy-D-streptamine (Chemical name for gentamicin C(sub 1A)) Gentamycin Solution