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(R)-(+)-2-Methyl-2-propanesulfinamide

(R)-(+)-2-Methyl-2-propanesulfinamide structure

CAS No.: 196929-78-9

Chemical Name:: (R)-(+)-2-Methyl-2-propanesulfinamide

Synonyms: (R)-2-METHYLPROPANE-2-SULFINAMIDE;(R)-TERT-BUTANESULFINAMIDE;(R)-2-METHYL-2-PROPANESULFINAMIDE;Trityl glycidyl ether;(R)-N-tert-Butanesulfinamide;DASO-002;Borax LR;R-(+)-TBSA;-2-propanesuL;Nicotinamide Impurity 18

CBNumber:: CB2765464

Molecular Formula:: C4H11NOS

Molecular Weight:: 121.2

MDL Number:: MFCD05861479

MOL File:: 196929-78-9.mol

MSDS File:: SDS

Last updated:2024-01-17 18:41:23

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(R)-(+)-2-Methyl-2-propanesulfinamide Properties

Melting point	103-107 °C(lit.)
Boiling point	220.0±23.0 °C(Predicted)
alpha	4 º (c=1, CHCl3 + amylenes)
Density	0.903 g/mL at 25 °C
refractive index	4 ° (C=1, CHCl3)
Flash point	-17℃
storage temp.	2-8°C
solubility	Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents.
form	Powder
pka	10.11±0.50(Predicted)
color	White, light pink, light yellow to brown
optical activity	[α]22/D +1.0°, c = 0.5% in chloroform
Stability	store cold
InChIKey	CESUXLKAADQNTB-SSDOTTSWSA-N
CAS DataBase Reference	196929-78-9(CAS DataBase Reference)
FDA UNII	7FEC1T720F

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07,GHS08

Signal word

Danger

Hazard statements

H225-H302-H319-H335-H351

Precautionary statements

P210-P280-P301+P312+P330-P305+P351+P338-P370+P378-P403+P235

Hazard Codes

Xi,Xn,F

Risk Statements

11-19-36/37-40-36/37/38

Safety Statements

22-24/25-36/37-26-16-36/37/39

RIDADR

UN 2056 3 / PGII

WGK Germany

Hazard Note

Irritant/Keep Cold

TSCA

HS Code

29309090

NFPA 704

	1
2		0

(R)-(+)-2-Methyl-2-propanesulfinamide price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	497401	(R)-(+)-2-Methyl-2-propanesulfinamide 98%	196929-78-9	1g	$85	2024-03-01	Buy
Sigma-Aldrich	497401	(R)-(+)-2-Methyl-2-propanesulfinamide 98%	196929-78-9	5g	$172	2024-03-01	Buy
TCI Chemical	B2907	(R)-(+)-tert-Butylsulfinamide >98.0%(GC)	196929-78-9	1g	$59	2024-03-01	Buy
TCI Chemical	B2907	(R)-(+)-tert-Butylsulfinamide >98.0%(GC)	196929-78-9	5g	$175	2024-03-01	Buy
Alfa Aesar	H27724	(R)-(+)-2-Methyl-2-propanesulfinamide, 98%	196929-78-9	1g	$60.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
497401	1g	$85	Buy
497401	5g	$172	Buy
B2907	1g	$59	Buy
B2907	5g	$175	Buy
H27724	1g	$60.65	Buy

(R)-(+)-2-Methyl-2-propanesulfinamide Chemical Properties,Uses,Production

Chemical Properties

(R)-(+)-2-Methyl-2-propanesulfinamide is white to light yellow crystal powde

Uses

suzuki reaction, useful reagent for synthesizing chiral amines.

Uses

Chiral ligand used in pharmaceutical compositions

Uses

(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.

Preparation

Acetic acid (70 g), R-tert-butylsulfinylhydrazine (42 g), zinc powder (60.5 g) and dichloromethane (150 mL) were added to the reaction flask. The temperature was slowly heated to 35-42 °C . After 16 hours, the filtrate was poured into 70 mL water. Dichloromethane (75 g×5) was added for extraction. Collected the organic phase, added 48% NaOH to adjust ρΗ (7-8). Then added NaCl, the layers were separated and the organic phase was washed with 15 g saturated aqueous solution of sodium chloride. The solution was dried over magnesium sulfate. After filterED, filtrate was concentrated under reduced pressure at 25-30 °C until no slipping. N-heptane was replaced, 28 g mixed solvent of N-heptane and toluene (N-heptane: toluene = 6:1) were added to perform beating at low temperature, filtered to obtain (R)-(+)-2-Methyl-2-propanesulfinamide. Yield=83%
(R)-( )-2-Methyl-2-propanesulfinamide

References

[1] Qian X, et al. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR α/γ dual agonist. Tetrahedron, 2015; 71: 9408-9414.

(R)-(+)-2-Methyl-2-propanesulfinamide synthesis

Synthesis of (R)-(+)-2-Methyl-2-propanesulfinamide from (R)-tert-Butanethiosulfinate

(R)-(+)-2-Methyl-2-propanesulfinamide Preparation Products And Raw materials

Raw materials

Vanadyl acetylacetonate 2-Chloro-2-methylpropane Hydrogen peroxide Sodium sulfate (S)-TERT-LEUCINOL

3,5-Di-tert-butylsalicylaldehyde Sulfur dioxide Potassium carbonate Ferric nitrate Triethylamine

(R)-(+)-1-Phenylethylamine Palladium Di-tert-butyl disulfide L-1-Phenylethylamine Tetrahydrofuran

Diethyl ether Ammonium chloride Ethyl acetate Hydrochloric acid Dichloromethane

Methanol Thionyl chloride PETROLEUM ETHER Magnesium Lithium

Sulfuric acid Ammonia

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Preparation Products

(R)-(+)-2-Methyl-2-propanesulfinamide Suppliers

Global( 464)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu shring Biopharma Co., Ltd.	+8613372282299	sales@shringchem.com	China	3545	58
Changzhou uniringchem Co., Ltd.	+undefined13585446801	sales@uniringchem.com	China	68	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Kindchem(Nanjing)Co.,Ltd	+86-025-025-85281586 +8618651653755	sales@kindchem.cn	China	1227	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6710	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55

Supplier	Advantage
Jiangsu shring Biopharma Co., Ltd.	58
Changzhou uniringchem Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Kindchem(Nanjing)Co.,Ltd	58
Shanghai UCHEM Inc.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55

View Lastest Price from (R)-(+)-2-Methyl-2-propanesulfinamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-02-23	(R)-(+)-2-Methyl-2-propane sulfinamide 196929-78-9	US $10.00-90.00 / g	5g	0.98	25kg	Shanghai UCHEM Inc.
2024-01-17	(R)-(+)-2-Methyl-2-propanesulfinamide 196929-78-9	US $0.00-0.00 / G	10G	0.98	500kg	Kindchem(Nanjing)Co.,Ltd
2023-07-29	(R)-(+)-2-Methyl-2-propanesulfinamide 196929-78-9	US $50.00 / KG	1KG	99%	20tons	Hebei Mojin Biotechnology Co., Ltd

(R)-(+)-2-Methyl-2-propane sulfinamide
196929-78-9
US $10.00-90.00 / g
0.98
Shanghai UCHEM Inc.

(R)-(+)-2-Methyl-2-propanesulfinamide
196929-78-9
US $0.00-0.00 / G
0.98
Kindchem(Nanjing)Co.,Ltd

(R)-(+)-2-Methyl-2-propanesulfinamide
196929-78-9
US $50.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

(R)-(+)-2-Methyl-2-propanesulfinamide Spectrum

(R)-(+)-2-Methyl-2-propanesulfinamide(196929-78-9)¹HNMR (R)-(+)-2-Methyl-2-propanesulfinamide(196929-78-9)FT-IR

196929-78-9((R)-(+)-2-Methyl-2-propanesulfinamide)Related Search:

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METSULFURON METHYL tert-Butyl methyl ether Methyl acetate Methyl 4-tert-butylbenzoate Methylparaben

Bensulfuron methyl tert-Butyl hydroperoxide 4-tert-Butylcatechol Thiophanate-methyl Kresoxim-methyl

TERT-BUTYLSULFONAMIDE Methyl Parathion-methyl

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R- tert butyl sulfenaMide (R)-(+)-TERT-BUTANESULFINAMIDE (R)-(+)-T-BUTANESULFINAMIDE (R)-(+)-T-BUTYLMETHYLSULFINAMIDE (R)-(+)-T-BUTYLSULFINAMIDE (R)-(+)-TERT-BUTYLSULFINAMIDE (R)-(+)-TERT-BUTYL SULPHINAMIDE (R)-(+)-2-METHYL-PROPANE-2-SULFINIC ACID AMIDE (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE (R)- (+)- 2-Methyl-2-propanesulphinaMide (R)-(+)-2-Methyl-2-propanesulfinaMide / (R)-tert-ButanesulfinaMide (R)-(+)-2-Methyl-2-propanesulfinamide solution 2-Propanesulfinamide, 2-methyl-, [S(R)]- (R)-(+)-tert-Butylsulfinamide (R)-(+)-2-Methyl-2-propanesulfinaMide, 97+% (R)-(+)-2-Methyl-2-propanesulfinamide 98% (R)-(+)-2-Methyl-2-propanesulfinamide≥ 99% (HPLC, Chiral purity) (R)-2-Methyl-2-propanesulfinamide,99%e.e. (R)-TERT-BUTANESULFINAMIDE / (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE, 98+% R-(+)-Tert-Butansulfinamide (R)-(+)-t-Butylmethylsulfinamide,min.97% (R)-(+)-tert-Butyl sulphinamide 98% (R)-(+)-t-Butyl sulfinamide, 98% ee (R)-(+)-2-Methylpropane-2-sulphinamide (R)-(+)-t-Butylmethylsulfinamide, min. 97% (R)-(+)-Methyl-2-propanesulfinamide (R)-(+)-2-Methylpropane-2-sulphinamide 98% R-(+)-TBSA (R)-(+)-t-Butylsulfinamide, min. 97% (R)-(+)-2-methyyl-2-propanesulfinamide DASO-002 (R)-(+)-tert-Butylsulfinamide > -2-propanesuL (R)-(+) -tert-butylsulfonamide (R)-(+)-2-Methyl-2-propanesulfinamide USP/EP/BP (R)-(-)-2-Methyl-2-Propane sulfonamide (R)-TERT-BUTANESULFINAMIDE (R)-2-METHYLPROPANE-2-SULFINAMIDE (R)-2-METHYL-2-PROPANESULFINAMIDE Trityl glycidyl ether (R)-N-tert-Butanesulfinamide RSYY（Donepezil Hydrochloride)-8 Nicotinamide Impurity 18 Borax LR S-(tert-butyl) (R)-2-methylpropane-2-sulfinothioate 196929-78-9 1969-78-9 96929-78-9 3196929-78-9 C6H19NOS C4H11OSN Chiral Auxiliaries Asymmetric Synthesis Sulfur-Based Synthetic Organic Chemistry CHIRAL CHEMICALS Sulfur Compounds