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XY028-133

XY028-133 structure

CAS No.: 2229974-73-4

Chemical Name:: XY028-133

Synonyms: XY028-133;L-Prolinamide, N-[7-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-1,7-dioxoheptyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CBNumber:: CB28054582

Molecular Formula:: C53H67N11O7S

Molecular Weight:: 1002.23

MDL Number:: MFCD34469555

MOL File:: 2229974-73-4.mol

Last updated:2023-05-21 10:59:17

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XY028-133 Properties

Density	1.307±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C, sealed storage, away from moisture and light
solubility	DMSO : 50 mg/mL (49.89 mM; Need ultrasonic)
pka	14.08±0.40(Predicted)

XY028-133 Chemical Properties,Uses,Production

Biological Activity

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity[1]. XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

References

[1]. JIN, Jian, et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.

XY028-133 Preparation Products And Raw materials

Raw materials

Preparation Products

XY028-133 Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3423	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9767	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1304	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
Henan Alpha Chemical Co., Ltd.	0371-55013243 15324716602	2853979810@qq.com	China	9957	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4164	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	market@aladdin-e.com	China	48467	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Jilin Province Woda Biotechnology Co., Ltd.	58
Changzhou Bojia Biomedical Technology Co., Ltd.	58
Henan Alpha Chemical Co., Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58

XY028-133 L-Prolinamide, N-[7-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-1,7-dioxoheptyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- (2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 2229974-73-4