ChemicalBook >> CAS DataBase List >>Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester structure

CAS No.: 2244161-73-5

Chemical Name:: Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Synonyms: DOLUTEGRAVIR IMPURITY;Dolutegravir Impurity 60;sodium (R)-7-((2,4-difluorobenzyl)carbamoyl)-2-(4-(((2,4-difluorobenzyl)carbamoyl)oxy)butan-2-yl)-1,

CBNumber:: CB28214977

Molecular Formula:: C28H24F4N4O6

Molecular Weight:: 588.51

MDL Number:

MOL File:: 2244161-73-5.mol

Last updated:2022-12-21 16:56:50

Request For Quotation

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Properties

Boiling point	778.0±60.0 °C(Predicted)
Density	1.51±0.1 g/cm3(Predicted)
pka	4.50±1.00(Predicted)
FDA UNII	YMS8WH5LQD

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Chemical Properties,Uses,Production

Uses

Des-butanoyl 3,4-Didehydro-N-butyl(2,4-difluorobenzyl)carbamate Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
AFINE CHEMICALS LIMITED	0571-85134551 18958018566;	info@afinechem.com	China	15377	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd.	020-89854820	sales@jzpharma.cn	China	1050	58
QUALITY CONTROL SOLUTIONS LTD.	13670046396	ORDERS@QCSRM.COM	China	18820	58
Shenzhen Roark Pharma-Tec Co., Ltd.	13128912434	2880126944@qq.com	China	2580	58
Aurisco Pharmaceutical (Tianjin) Inc.	022-59885855	liuyujie@aurisco.com	China	96	58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd	18502726233	3641133981@qq.com	China	9341	58

Supplier	Advantage
AFINE CHEMICALS LIMITED	58
China National Standard Pharmaceutical Corporation Limited	58
Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd.	58
QUALITY CONTROL SOLUTIONS LTD.	58
Shenzhen Roark Pharma-Tec Co., Ltd.	58
Aurisco Pharmaceutical (Tianjin) Inc.	58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd	58

DOLUTEGRAVIR IMPURITY sodium (R)-7-((2,4-difluorobenzyl)carbamoyl)-2-(4-(((2,4-difluorobenzyl)carbamoyl)oxy)butan-2-yl)-1, Dolutegravir Impurity 60 2244161-73-5 C28H24F4N4O6