L-Homoserine
- CAS No.
- 672-15-1
- Chemical Name:
- L-Homoserine
- Synonyms
- HOMOSERINE;HSE;(S)-2-AMINO-4-HYDROXYBUTANOIC ACID;H-HOMOSER-OH;H-HSE-OH;H-HOSER-OH;H-HOMOSERINE;(2S)-2-Amino-4-hydroxybutanoic acid;RODH;SDR9C6
- CBNumber:
- CB2854094
- Molecular Formula:
- C4H9NO3
- Molecular Weight:
- 119.12
- MDL Number:
- MFCD00063090
- MOL File:
- 672-15-1.mol
- MSDS File:
- SDS
Melting point | 203 °C (dec.)(lit.) |
---|---|
Boiling point | 222.38°C (rough estimate) |
alpha | -8.5 º (c=2, H2O 22 ºC) |
Density | 1.3126 (rough estimate) |
refractive index | 1.4183 (estimate) |
storage temp. | Store below +30°C. |
solubility | 1100g/l |
form | Crystalline Powder |
pka | 2.71(at 25℃) |
color | White to light yellow |
Water Solubility | 1100 g/L (30 ºC) |
Merck | 14,4739 |
BRN | 1721681 |
InChIKey | UKAUYVFTDYCKQA-VKHMYHEASA-N |
LogP | -1.289 (est) |
CAS DataBase Reference | 672-15-1(CAS DataBase Reference) |
FDA UNII | 6KA95X0IVO |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P271-P280 | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 24/25-44-35-26-28-7-4-3/9 | |||||||||
WGK Germany | 3 | |||||||||
F | 10 | |||||||||
HS Code | 29225000 | |||||||||
NFPA 704 |
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L-Homoserine price More Price(58)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | H6515 | L-Homoserine | 672-15-1 | 1g | $365 | 2024-03-01 | Buy |
Sigma-Aldrich | H6515 | L-Homoserine | 672-15-1 | 5g | $1720 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.14359 | L-(-)-Homoserine for synthesis | 672-15-1 | 1g | $147 | 2024-03-01 | Buy |
TCI Chemical | H1030 | L-Homoserine >98.0%(T) | 672-15-1 | 1g | $62 | 2024-03-01 | Buy |
TCI Chemical | H1030 | L-Homoserine >98.0%(T) | 672-15-1 | 5g | $204 | 2024-03-01 | Buy |
L-Homoserine Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystalline powder
Uses
L-Homoserine is used in the biosynthesis of methionine, threonine and isoleucine. It is also used as an internal standard for neurotransmitter analysis and amino acids quantification.
Definition
ChEBI: L-homoserine is the L-enantiomer of homoserine. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite and an Escherichia coli metabolite. It is an enantiomer of a D-homoserine. It is a tautomer of a L-homoserine zwitterion.
Synthesis Reference(s)
Journal of the American Chemical Society, 80, p. 3147, 1958 DOI: 10.1021/ja01545a057
The Journal of Organic Chemistry, 24, p. 1794, 1959 DOI: 10.1021/jo01093a610
General Description
L-Homoserine is a variant of serine with an additional carbon on its side chain.
Biochem/physiol Actions
L-Homoserine is synthesized by deoxidation process, catalysed by homoserine dehydrogenase. This is one of the steps in the synthesis of L-threonine. The carbon flux in in bacteria such as E. coli is maintained by this reaction.
Purification Methods
Likely impurities are N-chloroacetyl-L-homoserine, N-chloroacetyl-D-homoserine, L-homoserine, homoserine lactone, homoserine anhydride (formed in strong solutions of homoserine if slightly acidic). It cyclises to the lactone in strongly acidic solution. It crystallises from water by adding 9 volumes of EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2612-2616 1961, Beilstein 4 IV 3187.]
L-Homoserine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from L-Homoserine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-02-21 | L-Homoserine
672-15-1
|
US $0.00 / KG | 1KG | 98.0% | 100 tons | Honest Joy Holdings Limited
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2021-10-14 | L-Homoserine
672-15-1
|
US $0.00 / KG | 1KG | 98.0% | 5000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2021-07-13 | L-Homoserine
672-15-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- L-Homoserine
672-15-1
- US $0.00 / KG
- 98.0%
- Honest Joy Holdings Limited
- L-Homoserine
672-15-1
- US $0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
- L-Homoserine
672-15-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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