N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide

N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide structure

CAS No.: 88124-26-9

Chemical Name:: N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide

Synonyms: adosupine;N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide;Acetamide, N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)-

CBNumber:: CB2938217

Molecular Formula:: C17H14N2O3

Molecular Weight:: 294.3

MDL Number:: MFCD00867193

MOL File:: 88124-26-9.mol

Last updated:2022-12-21 16:56:50

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N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide Properties

FDA UNII	OKB1O47Q6F

N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide Chemical Properties,Uses,Production

Originator

Adosopine ,Menarini Group

Manufacturing Process

2 ml of acetic anhydride are added to 2.5 g of 10-amino-5,6-dihydro-11Hdibenzo[ b,e]azepine-6,11-dione (prepared from 1-aminoanthraquinone in accordance with Caronna and Palazzo-Gaz. Chim. It. 83, 533, 1953) in 50 ml of dioxane. After maintaining for 2 h under reflux, the mixture is evaporated almost to dryness under reduced pressure, the residue is then poured into water, filtered and dried to give 2.0 g of crude product.
The 2.0 g of previously obtained crude product is suspended in 20 ml of N,Ndimethylformamide, and 710.0 mg of sodium methylate in 10 ml of methanol are added. After maintaining for 30 min at room temperature, 2.5 ml of methyl iodide are added, and mixture is allowed to stand for 24 h after which the mixture is poured into water, the product filtered off, dried and crystallized from ethanol, to give 5-methyl-10-acetamino-5,6-dihydro-11H-dibenzo[b,e] azepine-6,11-dione, melting point 199°-201°C.

Therapeutic Function

Urinary incontinence agent

N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide Preparation Products And Raw materials

Raw materials

1-Aminoanthraquinone Iodomethane Sodium Methoxide Acetic anhydride

Preparation Products

N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)acetamide adosupine Acetamide, N-(6,11-dihydro-5-methyl-6,11-dioxo-5H-dibenz[b,e]azepin-10-yl)- 88124-26-9