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L-Aspartic acid

Chemical Properties Uses Production
L-Aspartic acid
L-Aspartic acid
CAS No.
56-84-8
Chemical Name:
L-Aspartic acid
Synonyms
ASP;L-ASP;L-Asp-OH;H-ASP-OH;FEMA 3656;ASPARTATE;H-L-ASP-OH;Aspatofort;L-ASPARGINE;ASPARTIC(L-)
CBNumber:
CB3141599
Molecular Formula:
C4H7NO4
Formula Weight:
133.1
MOL File:
56-84-8.mol

L-Aspartic acid Properties

Melting point:
>300 °C (dec.)(lit.)
alpha 
25 º (c=8, 6N HCl)
Density 
1.66
FEMA 
3656 | L-ASPARTIC ACID
storage temp. 
Store at RT.
solubility 
H2O: 5 mg/mL
form 
powder
pka
1.99(at 25℃)
color 
White
PH
2.5-3.5 (4g/l, H2O, 20℃)
Water Solubility 
5 g/L (25 ºC)
Merck 
14,840
BRN 
1723530
Stability:
Stable. Combustible. Incompatible with strong oxidising agents.
CAS DataBase Reference
56-84-8(CAS DataBase Reference)
NIST Chemistry Reference
Aspartic acid(56-84-8)
EPA Substance Registry System
L-Aspartic acid(56-84-8)

SAFETY

Hazard Codes  Xi,Xn
Risk Statements  36-36/37/38-20/21/22
Safety Statements  26-24/25-22-36
WGK Germany  2
RTECS  CI9098500
10
TSCA  Yes
HazardClass  IRRITANT
HS Code  29224995
Hazardous Substances Data 56-84-8(Hazardous Substances Data)

L-Aspartic acid price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1043819 Aspartic acid United States Pharmacopeia (USP) Reference Standard 56-84-8 100mg $348.4 2017-11-08 Buy
Sigma-Aldrich 11189 L-Aspartic acid BioUltra, ≥99.5% (T) 56-84-8 1kg $379.5 2017-11-08 Buy
TCI Chemical A0546 L-Aspartic Acid >99.0%(T) 56-84-8 25g $14 2017-11-08 Buy
TCI Chemical A0546 L-Aspartic Acid >99.0%(T) 56-84-8 500g $43 2017-11-08 Buy
Alfa Aesar 43317 L-Aspartic acid, 99%, low metals content 56-84-8 500g $55.9 2017-11-08 Buy

L-Aspartic acid Chemical Properties,Uses,Production

Chemical Properties

The product is white crystal or crystalline powder, slightly sour in taste. Soluble in boiling water, slightly soluble in water at 25℃(0.5%), freely soluble in dilute acid and sodium hydroxide solution and insoluble in ethanol and ethyl ether. It decomposes when heated to 270 ℃. Its isoelectric point is 2.77 and its specific rotation is associated with the soluble solvent. It is dextral in the acid solution and water solution, but levorotary in the alkali solution. [α]25D+5.05 (C=0.5-2.0 g/ml, H2O). Combined with HNO2, alcohol or acyl chloride, it can produce L- malic acid, ester and amide respectively. It is the ingredient of unripe sugarcane and beet molasses.

Uses

It is used as an electrolyte supplement for aminophenol transfusion, inorganic ion supplement (K+, Ca+, etc.) and fatigue restorer. Potassium magnesium aspartate injection or oral solution can be used for arrhythmia, premature beat, tachycardia, hypokalemia, hypomagnesemia, heart failure, myocardial infarction, angina pectoris, hepatitis, cirrhosis and other diseases caused by cardiac glycoside poisoning. Due to its low toxicity, this product cannot be injected without dilution, and the patients with renal insufficiency and atrioventricular conduction block should use it with caution.

Production

L- aspartic acid is mainly produced by enzymatic method. L- aspartase acts on the fumaric acid and ammonia, that is, which generates L- aspartic acid.
  1. Strain Culturing: Eschrichia coli Asl.881 was cultured. The common meat juice medium is agarslantculture-medium. The vase medium comprises corn steep liquor 7.5%, fumaric acid 2.0% and MgSO4 7H2O 0.02%. Adjust the pH value of solution to 6.0 with ammonia water, then put 50-100ml culture medium into 500ml cone bottle after boiling and filtering. Take the fresh cultivated seeds on the slope or in the liquid, inoculate culture medium in shake flask, shake overnight at 37℃, adjust pH to 5.0 with 1mol/L HCl after enlarging culture step by step to 1000-2000L, cool it to room temperature after keeping 45℃ for 1h, centrifuge in rotary supercentrifuge and collect the thallus including aspartase.
  2. Immobilize aspartase: Make a bioreactor to take out 20kg E.Coli wet cell, suspend it in the culture supernatant after centrifugation in 80L (or 80L saline), keep it at 40℃ and then add 90L 12% gelatin solution and 1.0% glutaraldehyde solution, which should be held 40℃.  Stir well, set aside to cool down and solidify, soak in 0.25% glutaraldehyde solution, hold 5℃ after an overnight, cut into small pieces ( 3-5 mm3) , soak in 0.25% glutaraldehyde solution at 5℃ for a night, take it out and elut with water, drain to obtain immobilized E.Coli containing aspartase and load it into filled bioreactor in reserve.
  3. Conversion: The solution of 1 mol/L of ammonium fumarate (including 1mmol/L MgCl2, pH8.5) substrate, which keeps 37℃, flows through a bioreactor at a constant speed (SV) continuously in the case of controlling the maximum conversion rate over 95% and then the conversion solution is obtained.
  4. Roughhew and refine:  Add 1 mol/L of HCl into the conversion solution gradually to adjust pH valkue to 2.8, place at 5℃ overnight for crystallizing, filter to prepare crystallization, drain after water washing, drying at 105℃ to obtain L- aspartic acid crude. Use dilute ammonia to recrystallize, dissolve into 15% solution (pH5.0) with ammonia, add 1% activated carbon, stir and fade for 1h when heat to 70℃, filter immediately to remove slag, cool the filtrate, hold 5℃ overnight for crystallizing, filter to get crystallization and obtain the L-Aspartic acid finished products after vacuum drying at 85℃.

Description

L-Aspartic acid is the L-form of the aspartic acid. It is one of the 20 amino acids that used in the protein synthesis. It is the non-essential amino acids for humans as it can be synthesized in vivo. It is important in the synthesis of other amino acids and some nucleotides, and is a metabolite in the citric acid and urea cycles. In animals, it may be used as a neurotransmitter. It can be chemically synthesize from the diethyl sodium phthalimidomalonate. Currently, almost all the aspartic acids are manufactured in China. Its application include being used as low calorie sweetener (as the part of the aspartame), scale and corrosion inhibitor, and in resins. One of its growing applications is for the manufacturing of biodegradable superabsorbent polymer, polyaspartic acid. It can also be used in fertilizer industry to improve water retention and nitrogen uptake.

Uses

L-aspartic acid is used as a dietary supplement, it can be blended with minerals to make compounds like potassium aspartate, copper aspartate, manganese aspartate, magnesium aspartate, zinc aspartate and more. Increasing the absorption, and hence utilization potentials, of these minerals via the addition of aspartate induces certain health benefits. Many athletes use L-aspartic acid-based mineral supplements orally to enhance their performance capacities. Aspartic acid and glutamic acid play important roles as general acids in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins. It can help promote a robust metabolism, and is sometimes used to treat fatigue and depression. Aspartic acid is used as a component of parenteral and enteral nutrition. In pharmaceutical agents aspartic acid is used as an ammoniac detoxicating agent, hepar function accelerator and fatigue refresher.

Definition

ChEBI: The L-enantiomer of aspartic acid.

Biological Activity

Endogenous NMDA receptor agonist.

L-Aspartic acid Preparation Products And Raw materials

Raw materials

Preparation Products


L-Aspartic acid Suppliers

Global( 437)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 491 57
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20811 55
Mainchem Co., Ltd.
0592-6210733
0592-6210733 sales@mainchem.com CHINA 3168 55
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30309 84
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 021-34666753 33588661 33585969 33585366 13311639313 400-615-1668
+86-21-34979012 Info@shyrchem.com China 1780 55
Wuxi Jingyao Bio-Technology Co., Ltd. 0510-88770633 13961738808
0510-88770633 jingyaobiotech@126.com China 359 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96820 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15940 69

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