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Tazobactam sodium

Tazobactam sodium Structure
Tazobactam sodium structure
CAS No.
89785-84-2
Chemical Name:
Tazobactam sodium
Synonyms
TazobactuM SodiuM;TAZOBACTAM SODIUM SALT;Piperacillin sodium salt;D03707;ytr830;cl307579;CL-30757;TAZOBACTAM SODIUM;YTR-830H SODIUM SALT;TAZOBACTAMACID/SODIUM
CBNumber:
CB3181854
Molecular Formula:
C10H12N4NaO5S
Molecular Weight:
323.28
MDL Number:
MFCD00917472
MOL File:
89785-84-2.mol
Last updated:2024-01-17 16:57:51
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Tazobactam sodium Properties

Melting point 140-147°C
Boiling point 77℃
Flash point >110°(230°F)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: 50 mg/mL, clear, colorless
form powder
color white
optical activity [α]/D 144±4°, c = 0.1 in H2O
Water Solubility Soluble in water.Soluble in water and methanol.
Stability Hygroscopic
CAS DataBase Reference 89785-84-2(CAS DataBase Reference)
FDA UNII UXA545ABTT

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  XI0191500
HS Code  2941900000

Tazobactam sodium price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T2820 Tazobactam sodium salt β-lactamase inhibitor 89785-84-2 10mg $97.5 2024-03-01 Buy
Sigma-Aldrich 68300 Tazobactam sodium salt analytical standard 89785-84-2 5mg $88.8 2024-03-01 Buy
Alfa Aesar J66226 Tazobactam sodium 89785-84-2 100mg $67.65 2024-03-01 Buy
Alfa Aesar J66226 Tazobactam sodium 89785-84-2 1g $182 2024-03-01 Buy
Cayman Chemical 17185 Tazobactam (sodium salt) ≥95% 89785-84-2 100mg $32 2024-03-01 Buy
Product number Packaging Price Buy
T2820 10mg $97.5 Buy
68300 5mg $88.8 Buy
J66226 100mg $67.65 Buy
J66226 1g $182 Buy
17185 100mg $32 Buy

Tazobactam sodium Chemical Properties,Uses,Production

Description

Tazobactam sodium is a new triazolylmethyl beta-lactamase inhibitor launched in combination with the antibiotic piperacillin as tazocilline. Tazobactam sodium is active against penicillinases and wide spectrum of beta-lactamases. The combination product tazobactdpiperacillin is effective against a broad range of both Gram-positive and -negative organisms and is indicated for the treatment of lower respiratory tract, urinary tract, intra-abdominal, biliary and skin and soft tissue infections. It is expected to compete against the combination product augmentin (amoxicillidclavulanate).

Chemical Properties

White to off-white powder

Originator

Taiho (Japan)

Uses

A β-lactamase inhibitor and antibacterial agent

Uses

β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.

Uses

Lactamase inhibitor, used with ?lactam antibiotics to enhance their effect

Uses

Tazobactam sodium is a beta-Lactamase inhibitor, which is used with penicillinase inhibition studies and beta-lactam antibiotics to enhance their effect. It serves as an antibacterial penicillin derivative, which inhibits the action of bacterial beta-lactamases.

Definition

ChEBI: Tazobactam sodium is an organic sodium salt having tazobactam(1-) as the counterion; used in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections. It has a role as an antimicrobial agent, an antiinfective agent and an EC 3.5.2.6 (beta-lactamase) inhibitor. It contains a tazobactam(1-).

Manufacturing Process

A known β-lactam type antibiotic (for example, benzhydryl 2-β-chloromethyl- 2-α-methylpenam-3-α-carboxylate) was used for synthesis of new penicillinic derivatives.
A solution of 5.00 g of sodium azide in 53 ml of water was added to a solution of benzhydryl 2-β-chloromethyl-2-α-methylpenam-3-α-carboxylate (5.13 g) in dimethylformamide (155 ml). The mixture was stirred at room temperature for 4 h. The resulting reaction mixture was poured into cooled water and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over magnesium sulfate and concentrated to provide 4.87 g of the benzhydryl 2-β-azidomethyl-2-α-methylpenam-3-α-carboxylate as oil in 93% yield.
To a solution of benzhydryl 2-β-azidomethyl-2-α-methylpenam-3-α- carboxylate (7.03 g) in a mixture of acetic acid (240 ml) and water (40 ml) was added potassium permanganate (6.02 g) over a period of more than 1 h. The mixture was stirred at room temperature for 2.5 h. The resulting reaction mixture was diluted with ice water. The precipitate was collected by filtration, and washed with water. The resulting product was dissolved in ethyl acetate and the solution was washed with an aqueous solution of sodium hydrogen carbonate and dried over magnesium sulfate. Concentration gave 5.48 g of the benzhydryl 2-β-azidomethyl-2-α-methylpenam-3-α-carboxylate-1,1-dioxide in 72% yield.
A 200 mg quantity of benzhydryl 2-β-azidomethyl-2-α-methylpenam-3-α- carboxylate-1,1-dioxide was reacted with 10 ml of vinyl acetate in a sealed reactor at 100° to 110°C for 30 h. The reaction mixture was concentrated at reduced pressure. The residue was crystallized with cooled chloroform. The white crystals of benzhydryl 2-α-methyl-2-β-(1,2,3-triazol-1-yl)methylpenam- 3-α-carboxylate-1,1-dioxide have a melting point 206°-208°C, dec.
Hydrogenation was conducted in 10 ml of ethyl acetate and 10 ml of water at room temperature for 30 min by using 45 mg of benzhydryl 2-α-methyl-2-β- (1,2,3-triazol-1-yl)methylpenam-3-α-carboxylate-1,1-dioxide, 15 mg of 10% palladium charcoal and 16 mg of sodium hydrogen carbonate. The aqueous layer was separated from the reaction mixture and washed once with ethyl acetate. The aqueous solution was then purified with an MCl gel, CHP-20P (product of Mitsubishi Kasei Co., Ltd., Japan). After freeze-drying, there was obtained an amorphous product of sodium 2-α-methyl-2-β-(1,2,3-triazol-1- yl)methylpenam-3-α-carboxylate-1,1-dioxide with a melting point 170°C, dec.

brand name

Tazocilline

Therapeutic Function

Antibiotic

Tazobactam sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Tazobactam acid

Tazobactam sodium Suppliers

Global( 265)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12453 58
Sinoway Industrial co., ltd. 		0592-5800732; +8613806035118 xie@china-sinoway.com China 992 58
Wuhan Xinhao Biotechnology Co., Ltd 		+86-18120578002 +86-18120578002 xinhao-6@xinhaoshengwu.com China 350 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8822 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Sinoway Industrial co., ltd. 		58
Wuhan Xinhao Biotechnology Co., Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58

View Lastest Price from Tazobactam sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tazobactam sodium pictures 2024-04-10 Tazobactam sodium
89785-84-2
 US $0.00-0.00 / Kg/Bag 1Kg/Bag 99% up, High Density 20 tons Sinoway Industrial co., ltd.
Tazobactam sodium pictures 2024-04-02 Tazobactam sodium
89785-84-2
 US $10.00-100.00 / kg 1kg 99% 5000 Metric Ton/Month Wuhan Xinhao Biotechnology Co., Ltd
Tazobactam sodium pictures 2023-08-29 Tazobactam sodium
89785-84-2
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
  • Tazobactam sodium pictures
  • Tazobactam sodium
    89785-84-2
  • US $0.00-0.00 / Kg/Bag
  • 99% up, High Density
  • Sinoway Industrial co., ltd.
  • Tazobactam sodium pictures
  • Tazobactam sodium
    89785-84-2
  • US $10.00-100.00 / kg
  • 99%
  • Wuhan Xinhao Biotechnology Co., Ltd

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TAZOBACTAM SODIUM 2-alpha-methyl-2-beta-(1,2,3-triazol-1-ylmethyl)penam-3-alpha-carboxylicacid 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-,4,4-dioxide,sodiumsalt,(2s-(2-alpha,3-beta,5-alp4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicaci 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3-methyl-7-oxo-3-(1h-1,2,3 cl307579 [2s-(2α,3β,5α)]-3-methyl-7-oxo-3(1h,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide CL-298741, YTR-830H, [2S-(2α, 3β, 5α)]-3-Methyl-7-oxo-3(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide (2S,3R,5R)-3-Methyl-7-oxo-2-sodiooxycarbonyl-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane4,4-dioxide 3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxidesodium salt D03707 Tazobactam sodium (usan) TAZOBACTAMACID/SODIUM TazobactaM SodiuM API 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylMethyl)-, 4,4-dioxide, sodiuM salt(1:1), (2S,3S,5R)- -triazol-1-ylmethyl)-,4,4-dioxide,sodiumsalt,(2s-(2-alpha,3-beta,5-alpha)) ytr830 YTR-830H SODIUM SALT [2S-(2ALPHA, 3BETA, 5ALPHA)]-3-METHYL-7-OXO-3(1H,2,3-TRIAZOL-1-YLMETHYL)-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID 4,4-DIOXIDE SODIUM SALT [2s-(2a,3b,5a)]-3-methyl-7-oxo-3(1h,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt CL-298741 SODIUM SALT (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-dioxide Sodium Salt CL-30757 Sodium (2S, 3S, 5R)-3-methyl-7-oxo-3-(1H -1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate-4,4-dioxide sodium 3-methyl-4,4,7-trioxo-3-(1-triazolylmethyl)-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Tazobactam sodium USP/EP/BP Tazobactam-[13C2, 15N3] Sodium salt Sodium (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide Tazobactam Sodium Salt 1N Tazobactam SodiumQ: What is Tazobactam Sodium Q: What is the CAS Number of Tazobactam Sodium Q: What is the storage condition of Tazobactam Sodium sodium 2β-<(1,2,3-triazol-1-yl)methyl>-2α-methylpenam-3α-carboxylate 1,1-dioxide TazobactuM SodiuM Piperacillin sodium salt TAZOBACTAM SODIUM SALT Caffeine Impurity 6-d3 89785-84-2 C10H11NaN4O5S C10H11N4O5SNa BioChemical Antibiotics T-Z Antibiotics Antibiotics A to Z Antibiotic pharmaceutical Intermediates & Fine Chemicals Pharmaceuticals Active Pharmaceutical Ingredients