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Hydroxypropyl methyl cellulose

Product features Usage method Ophthalmic remedy Identification test Toxicity Limited use Chemical property Uses Methods of production
Hydroxypropyl methyl cellulose
Hydroxypropyl methyl cellulose
CAS No.
9004-65-3
Chemical Name:
Hydroxypropyl methyl cellulose
Synonyms
HPMC;MHPC;hpmcd;goniosol;HPMC/MHPC;methocelhg;HPMC /HEMC;isoptoplain;isoptotears;HYPROMELLOSE
CBNumber:
CB3225318
Molecular Formula:
C3H7O *
Formula Weight:
59.08708
MOL File:
9004-65-3.mol

Hydroxypropyl methyl cellulose Properties

Density 
1.39
solubility 
H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow
form 
powder
color 
White to cream
Water Solubility 
SOLUBLE
Merck 
14,4842
Stability:
Stable. Solid is combustible, incompatible with strong oxidizing agents.
EPA Substance Registry System
Cellulose, 2-hydroxypropyl methyl ether(9004-65-3)

SAFETY

Safety Statements  24/25
WGK Germany  1
RTECS  NF9125000
3-10
TSCA  Yes
HS Code  39129000

Hydroxypropyl methyl cellulose price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 09963 (Hydroxypropyl)methyl cellulose 9004-65-3 25g $38.3 2017-11-08 Buy
Sigma-Aldrich 09963 (Hydroxypropyl)methyl cellulose 9004-65-3 100g $99.4 2017-11-08 Buy
Alfa Aesar 44779 Hydroxypropyl methylcellulose 9004-65-3 1kg $272 2017-11-08 Buy
Alfa Aesar 44779 Hydroxypropyl methylcellulose 9004-65-3 50g $30.8 2017-11-08 Buy
Sigma-Aldrich 09963 (Hydroxypropyl)methyl cellulose 9004-65-3 500g $235 2017-11-08 Buy

Hydroxypropyl methyl cellulose Chemical Properties,Uses,Production

Product features

Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles. The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose. Solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents. Soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel. Can be used alone in the cold drink, also can be used with other emulsifier, stabilizer. To cold drink, the maximum amount is 1%. Hydroxypropyl methyl cellulose and other water-soluble high weight compounds use mixture, become transparent, higher viscosity. The gelation temperature of low viscosity products is higher than high viscosity of products. Its solution is stable at room temperature. In recent years, It has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc.
The molecular structure of hydroxypropyl methyl cellulose
Figure 1 The molecular structure of hydroxypropyl methyl cellulose

Usage method

Purpose: thickener, emulsifier, stabilizer.
1 note: hydroxypropyl methyl cellulose has many excellent properties. It can be used for baking food, pasty food, enriched food, milk paste mixing drinks, pie fillings, toppings, salad and fast food. The use of its thermal gel properties can make deep fried food, not only can save a lot of oil, but also the product has a unique taste of the soft. The use of its acid, alkali stability, anti-enzymes, do not participate in metabolism, enhance the characteristics of gastrointestinal motility, but also used to produce a variety of health food.
2 usage range and usage
(1) The provisions on the use of hygienic standards for food additives (GB 2760-1996) shall be used in all kinds of food appropriately.
(2) The actual use of reference: the use of high transparency film and film of this product can be used in the manufacture of casings, dosage is 5%. It is used as a thickener mayonnaise (HPMC-60RT400), dosage of 0.5%~2%.

Ophthalmic remedy

[Application] Through the stability and thickening of anterior corneal tear, it can promote corneal moist, cut off time, extend the tear film in dry eyes and can prolong the retention time of tear film. It used for the lack of clinical tear caused by dry eyes and eye irritation, and the treatment of keratoconjunctivitis sicca, exposure keratitis and Neuroparalytic keratitis to prevent corneal injury. It can be used for hard contact lenses or artificial eye lubricant. For gonioscopy, contact endoscopy and surgery, it is as a medium in condensation genioplasty or retinal laser iridectomy in the process to protect the cornea.
[dosage] eye: 0.3%~1% solution, 1 drops, 3~4 times /d. 2% of the solution is used for the anterior chamber angle.
[Attention and taboo] Using it can sometimes have blurred vision or eyelid adhesion feeling. Continuous time should not exceed 3 Days. Wearing soft contact lens is banned to corneal epithelial disease. Wear a hard contact lens should prevent the lens floating.
[Specification] eye drops: 0.3%, 0.5%, 1%, 2.5%.
This information is edited by Chemicalbook Xiannan (2015-08-31).

Identification test

It is soluble in water swelling, forming a transparent milky white sticky gel solution, and insoluble in ethanol.

Toxicity

ADI does not make special provisions (FAO/WHO, 2001). It can be used for food safety (FDA. §172.87, 2000). LD505200mg/kg (rats, intra peritoneal injection).

Limited use

FAO/WHO (1984): Cold drink ,10g/kg (in the end product design, single use or with other emulsifier, stabilizer and thickener dosage).
GB 2760-96: all kinds of food, to GMP limited.

Chemical property

Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles.It has different types of products, the methoxy and hydroxypropyl content ratio is different. It is white or gray fibrous powder or particles. It is soluble in water and some organic solvents and unsoluble in ethanol. Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.

Uses

1. Thickener, stabilizer, emulsifier, emulsifier, suspending agent.
2. It is used as a synthetic resin dispersing agent, and the coating agent,also used as a thickener.
3. This product is used as a thickener, dispersant, binder, emulsifier and stabilizer in the textile industry. It is also widely used in synthetic resin, petrochemical, ceramics, paper, leather, medicine, food, cosmetics and other industries.
4. Used in synthetic resin, petroleum chemical industry, ceramics, paper, leather, textile, medicine, food, cosmetics and other daily chemicals and as dispersing agent, thickening agent, binders, excipients, capsules, oil resistant coating and packing etc.

Methods of production

1.The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range. The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa. The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying). The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t.
2.100 kg refined cotton linters immersed in 45% solution, temperature is 35 to 40℃, time is 0.5 to 1 h, and then remove the press. The pressure to weight is 2.7 times as the weight of lint, stop pressure. Carry out the crushing. At 35℃, aging for 16h.
In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle. At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of hydrochloric acid and oxalic acid were added to the hot water at 90℃. Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%. Finally, the finished product sieved by 20 mesh.
3. Prepared by cellulose, methyl chloride, and ethylene oxide.

Chemical Properties

white or slightly beige powder or a viscous solution

Uses

Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Uses

A thickener for aqueous and non-aqueous systems.

Hydroxypropyl methyl cellulose Preparation Products And Raw materials

Raw materials

Preparation Products


Hydroxypropyl methyl cellulose Suppliers

Global( 217)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 info@tnjchem.com China 1944 62
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
future industrial shanghai co., ltd 021-61552785,400-0066-400
021-55660885 sales@jonln.com China 2091 65
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30314 84
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 sales@hwrkchemical.com China 15554 55
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 14021 59
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21909 59
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 sales02@farchem.com China 9205 52
Chengdu XiYa Chemical Technology Co., Ltd. 4008-626-111
028-84752058 sale@xiyashiji.com China 9747 57

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