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Terpineol

CAS No.
8000-41-7
Chemical Name:
Terpineol
Synonyms
A-TERPINEOL;TERPINEOL 101 (ALPHA);Terpineol - Mixed Isomers;FEMA 3045;TERPINEOL, A-;TERPINEOL 318 TYPE;TILIANOL SUPER(TM);1-Methyl-4-isopropyl-1-cyclohexen-8-ol;TERPINEOL;TERPINEOL N
CBNumber:
CB3229316
Molecular Formula:
C10H18O
Molecular Weight:
154.25
MDL Number:
MFCD00001557
MOL File:
8000-41-7.mol
MSDS File:
SDS
Last updated:2024-03-14 18:29:10

Terpineol Properties

Melting point 18°C
Boiling point 213-218 °C (lit.)
Density 0.934 g/mL at 20 °C (lit.)
vapor pressure 3 hPa (20 °C)
refractive index 1.481-1.486
Flash point 95°C
storage temp. Store below +30°C.
solubility ethanol: soluble1.25ml/10ml, clear to slightly hazy, colorless to light yellow (50% ethanol)
form Liquid
color Clear colorless to slightly yellow
Odor at 100.00 %. fresh clean woody pine floral lime
Odor Type herbal
Water Solubility slightly
FreezingPoint 2℃
Dielectric constant 2.8(20℃)
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong acids.
InChIKey WUOACPNHFRMFPN-UHFFFAOYSA-N
LogP 3.330 (est)
Indirect Additives used in Food Contact Substances TERPINEOL
FDA 21 CFR 175.105
CAS DataBase Reference 8000-41-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII R53Q4ZWC99
EPA Substance Registry System Terpineol (8000-41-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Signal word  Warning
Hazard statements  H315-H319
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  38-36/37/38-36/38-37/38
Safety Statements  37-36-26-24/25
WGK Germany  2
RTECS  WZ6600000
TSCA  Yes
HS Code  29061990
Toxicity LD50 orally in Rabbit: 4300 mg/kg
NFPA 704
2
0 0

Terpineol price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W304506 Terpineol mixture of isomers, ≥96%, FG 8000-41-7 SAMPLE-K $54.6 2024-03-01 Buy
Sigma-Aldrich W304506 Terpineol mixture of isomers, ≥96%, FG 8000-41-7 1kg $69.8 2024-03-01 Buy
Sigma-Aldrich W304506 Terpineol mixture of isomers, ≥96%, FG 8000-41-7 10Kg $276 2024-03-01 Buy
Sigma-Aldrich W304506 Terpineol mixture of isomers, ≥96%, FG 8000-41-7 25kg $561 2024-03-01 Buy
Sigma-Aldrich 8.14759 Terpineol (mixture of isomers) for synthesis 8000-41-7 1L $159 2024-03-01 Buy
Product number Packaging Price Buy
W304506 SAMPLE-K $54.6 Buy
W304506 1kg $69.8 Buy
W304506 10Kg $276 Buy
W304506 25kg $561 Buy
8.14759 1L $159 Buy

Terpineol Chemical Properties,Uses,Production

Spices

Terpineol naturally occurs in pine oil, lavender oil, gallo oil, orange leaf oil, neroli oil and other essential oils. Turpentine is a kind of fragrance obtained through the hydration of α-pinene olefin or β-pinene to generate hydrated terpene glycol, followed by dehydration and fractionation. Terpineol is one of the earliest synthetic fragrances to achieve industrial production. It is mainly used as soap essence, and it has been more than 100 years old. Terpineol is a bulk spice products with a world annual output of thousands of tons. It is used in a wide variety of cosmetic formulations, especially in the formulation of soaps and synthetic detergents, up to 30%. IFRA has no restrictions.
Figure 1 shows the chemical reaction equation of the α-pinene terpineol.
Terpineol has the aroma of pine and lilac. It appears as a viscous liquid, but easy to subject to crystallization with the boiling point of 218 ~ 219 ℃, 85 ℃ / 400Pa, the melting point of 35 ℃ (α-terpineol). Mainly used to deploy lilac, lily of the valley, Acacia, orange blossom and other scented soap, cosmetics flavor. Pure α-terpineol can still be used for preparation of lemons, oranges, peaches and other food flavors. A lot of ester compounds prepared from terpineol are also excellent spices.

Physical and chemical properties

Terpineol has α, β, and γ three isomers. Based on their melting points, they should all belong to solid. However, the most marketing synthetic products are the mixture of these three isomers, appearing as liquid.
Alpha-terpineol has dextrorotatory, levorotatory and racemic 3 types. Right-handed alpha-terpineol naturally occurs in cardamom oil, orange oil, orange leaf oil, neroli oil, jasmine oil, nutmeg oil; levorotatory α-terpineol naturally occurs in pine needle oil, camphor oil, Leaf oil, lemon oil, lime oil, rosewood oil. Beta-terpineol has cis and trans isomers (rare in essential oils). γ-Terpineol is present in the form of free-form or ester in juniper wood oil.
Alpha-terpineol-based mixture is used in the spice. It appears as colorless viscous liquid. It has a unique clove aroma. The boiling point of 214 ~ 224 ℃, the relative density of d25250.930 ~ 0.936. Refractive index nD201.482 ~ 1.485. Insoluble in water, soluble in ethanol, propylene glycol and other organic solvents. α-terpineol exists in more than 150 kinds of plant leaves, flowers, grass stems. d-Polarimetry exists in cedar, cardamom, star anise, orange blossom and other essential oils. l-Polarimetry exists in miscellaneous lavender, Melaleuca, white lemon, cinnamon leaves and other essential oils.

Figure 2 for terpineol α, β, γ three isomers of the chemical structure

Pine oil

Pine oil is a products consisting of α-terpineol-based monoterpene alcohols and monoterpenes. Pine oil is light yellow to reddish brown oily liquid, being slightly soluble in water with a special odor. It has a strong bactericidal ability, good wetting, cleaning and permeability, being easily saponified or emulsified by other surfactants. It has good resistance to oils, fats and greases.

Ingredients: The main oxygenates include α-terpineol, β-terpineol, γ-terpineol, α-fenchol, borneol, isoborneol, camphor, terpinen-1, terpinene alcohol-4, dioxanone alcohol, methyltyrosol, anethole, 1,4-eucalyptol, 1,8-eucalyptol and so on. The major terpene components include terpinolene, limonene, alpha-terpinene, gamma-terpinene, para-methyl ene-2, 4 (8), para-cymene and sesquiterpenes. Synthetic pine oil contains much terpinolene, and does not contain anethole and methyl chelating phenols, traces of camphor. Steam distilled pine oil contains higher borneol and anethole.
the main component of synthetic pine oil
Figure 3 the main component of synthetic pine oil
Uses: A large number of pine oil is used as a flotation agent for mineral flotation (copper, lead and zinc ore and other non-ferrous metal ores), but also as a printing and dyeing auxiliaries, pigment humectants, paints anti-skinning agent, sheep skin degreasing agents, Epoxy leveling agents, anti-foaming agents for protein compounds in plywood industries, animal blood preservatives, and leveling agents in baking paints, paper coatings and enamels.

Toxicity

According to the data provided by RIFM, acute toxicity data of terpineol: oral LD50 4.3g / kg (rat), skin test LD50> 3g / kg (rabbit).

The function and use terpineol and use

Terpineol is divided into spice specifications and medicinal specifications; spice-grade terpineol has good aroma adaptability and good stability in the air and many aroma media, being widely used in a variety of purposes flavor formula. Meanwhile, it can be used to increase the fresh aroma; as the body fragrance, it is commonly used in incense lily, lilac, lily of the valley, acacia, rhodiola rosea, orange blossom; also important spice in magnolia, gardenia, narcissus and pine needle flavor. Terpineol is inexpensive and is widely used for blending advanced fragrances such as soap and cosmetic fragrances as well as lilac-like high-grade flavor and is used in the pharmaceutical, motor, ink and other industries. Fraction containing alcohol content of 40% to 80% is called synthetic pine oil, mainly used for flotation foaming agent of non-ferrous metal.
medicinal terpineol and spice terpineol
Figure 4 Quality indicators of the medicinal terpineol and spice terpineol

Synthesis method

The weight ratio of turpentine and 30% sulfuric acid ingredients is 1: 1.7 with 10% Pergal as emulsifier. The reaction temperature is 28-30 ℃. The reaction was allowed to stand for 24 hours and then stratified. The resulting hydrated terpene glycol crystals floated on the acid water; after removal of the acid water, the remained crystal and oil layer in the reaction pot was washed with water by 3 times; use dilute alkali to wash to neutral pH; apply rejection centrifuge to obtain hydrated terpene glycol crystal. 
The weight ratio of hydrated terpene glycol and 0.2% sulfuric acid ingredients is 1: 2; stir and send direct steam and indirect steam to heat to boiling; the reaction takes about 3 to 5 hours and ended until the specific gravity reached d204 0.933. Apply stand stratification and discharge the lower acid. Turbid layer is neutralized by dilute alkaline; remove the alkaline; stand for clarification; the oil layer is subject to fractionation and fractionally collected according to the proportion of distillate fraction; the finished or semi-finished product has a output of terpineol being 55% to 60%.

Description

Terpineol is a monoterpene alcohol that has been found in a variety of plants, including Cannabis, and has diverse biological activities. Terpineol contains the four isomers α-, β-, and γ-terpineol and terpinen-4-ol. α-Terpineol has antibacterial and antinociceptive properties. It is active against a variety of periodontopathic and cariogenic bacteria, including strains of P. gingivalis, F. nucleatum, and A. actinomycetemcomitans (MICs = 0.1-0.8 mg/ml), however, it is toxic to KB cells when used at a concentration of 0.8 mg/ml. It also reduces mechanical hyperalgesia, as well as spontaneous and palpation-induced nociception, in a mouse model of cancer-induced pain beginning on day 5 when administered at a dose of 50 mg/kg per day. Terpinen-4-ol has anticonvulsant properties, inhibiting pentylenetetrazol-induced seizures in mice when used at doses ranging from 50 to 200 mg/kg. α-Terpineol and terpinen-4-ol also have anti-inflammatory properties, reducing LPS-induced production of IL-1β, IL-6, and IL-10, but not TNF-α, in U937 cells. This product is a mixture of α-, β-, and γ-terpineol.

Chemical Properties

It appears as colorless liquid or low-melting transparent crystal with a clove flavor. 1 part of terpineol can be dissolved in 2 parts (volume) of 70% ethanol solution, being slightly soluble in water and glycerol.

Occurrence

Reported to be found in more than 200 derivatives from leaves, herbs and flowers [Fenaroli 's Handbook of Flavor Ingredients, 1971 ; Gildemeister & Hoffman, 1962).

Uses

Solvent for hydrocarbon materials, mutual solvent for resins and cellulose esters and ethers, perfumes, soaps, disinfectant, antioxidant, flavoring agent.

Uses

Terpineol is a monoterpene alcohol with potential antifungal, antioxidant and antiproliferative activities. This product is a mixture of isomers.

Preparation

From terpin hydrate by the splitting off of the elements of water by chemical means (Bedoukian, 1967).

Definition

ChEBI: Alpha-terpineol is a terpineol that is propan-2-ol substituted by a 4-methylcyclohex-3-en-1-yl group at position 2. It has a role as a plant metabolite.

General Description

α-Terpineol is a cyclic monoterpene. It is one of the major monoterpenol component of the cultivar Gewürztraminer and other aroma-rich grape varieties. α-Terpineol, a monoterpenoid alcohol, has been investigated for its anticonvulsant activity. It was one of the insecticidal constituent of the essential oils of Dahlia pinnata.FCC includes the following isomers in the listed purity: alpha-, (E)-beta, (Z)-beta, gamma-, terpinen-4-ol, and terpinen-1-ol.

Terpineol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 371)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 5085 58
Wuhan Boyuan Import & Export Co., LTD
+86-15175982296 15175982296; Mike@whby-chem.com China 981 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850 hbjbtech@163.com China 1000 58
Shandong Juchuang Chemical Co., LTD
+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58

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  • Feb 26,2024

View Lastest Price from Terpineol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Terpineol pictures 2024-03-15 Terpineol
8000-41-7
US $15.00-13.00 / kg 500kg 99.9 200ton Shandong Juchuang Chemical Co., LTD
Terpineol pictures 2024-01-08 Terpineol
8000-41-7
US $6.00 / kg 1kg 99.96% 500ton Wuhan Boyuan Import & Export Co., LTD
Terpineol pictures 2023-12-26 Terpineol
8000-41-7
US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
  • Terpineol pictures
  • Terpineol
    8000-41-7
  • US $15.00-13.00 / kg
  • 99.9
  • Shandong Juchuang Chemical Co., LTD
  • Terpineol pictures
  • Terpineol
    8000-41-7
  • US $6.00 / kg
  • 99.96%
  • Wuhan Boyuan Import & Export Co., LTD
  • Terpineol pictures
  • Terpineol
    8000-41-7
  • US $100.00-1.00 / KG
  • 99%
  • Henan Fengda Chemical Co., Ltd
TERPINEOL TERPINEOL 200 (ALPHA) TERPINEOL 350 TERPINEOL-ALPHA TERPINEOL N TERPINEOL PFG TILIANOL NP(TM) TERPINEOL (MIXTURE OF ISOMERS) FOR SYNTH Terpineol Mixture of isoMers, anhydrous 2-(4-METHYLCYCLO-3-HEXENYL)-2-PROPANOL 2-(4-METHYL-CYCLOHEX-3-ENYL)-PROPAN-2-OL 1-P-METHEN-8-OL AURORA KA-475 4-Menth-1-en-8-ol α,β or γ-Terpineol Terpineol anhydrous TERPINEOL, 4X25 ML TERPINEOL,PRACTICAL 2-(4-Methyl-3-cyclohexenyl)-2-propanol ALPHA, ALPHA, 4-TRIMETHYL-3-CYCLOHEXENE-1-METHANOL 3-CYCLOHEXENE-1-METHANOL, ALPHA, ALPHA, 4-TRIMETHYL Terpineol Perfum Grade Terpineol@100 μg/mL in Methanol TERPINEOL(PG/MU) TERPINEOL(MU) TERPINEOL(PG) Terpineol C Terpineol ISO 9001:2015 REACH Terpineol (>90%) terpineols (unspec.) (mixed isomers) Alpha Terpineol Terpineol Chemical Reagent Bloom Tech Terpineol CAS 8000-41-7 mixture of isomers, analytical standard TERPINEOL ANHYDROUS Extra Pure Terpineol, 95%, mixture of isomers Terpineol Pharma Grade (8006-39-1) terpineol Terpineol,Pure Terpineol of factory supply 8000-41-7 kf-wang(at)kf-chem.com Terpineol (> Terpineol Solution TERPINEOL 101 (ALPHA) TERPINEOL 318 TYPE TERPINEOL, A- Terpineol - Mixed Isomers A-TERPINEOL TILIANOL SUPER(TM) FEMA 3045 1-Methyl-4-isopropyl-1-cyclohexen-8-ol Tetraethylene glycol dimethyl ether 143-24-8 Terpineol (6CI, 8CI, 9CI, ACI) 8000-41-7 Organic Building Blocks Monocyclic Monoterpenes Terpenes Alkenes Building Blocks Cyclic Citrus aurantium (Seville orange)