Lumacaftor (VX-809)
- CAS No.
- 936727-05-8
- Chemical Name:
- Lumacaftor (VX-809)
- Synonyms
- Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;VRT 826809;3-(6-{[1-(2;VX809;VX-809;VX 809, >=98%
- CBNumber:
- CB32489655
- Molecular Formula:
- C24H18F2N2O5
- Molecular Weight:
- 452.41
- MDL Number:
- MFCD16659051
- MOL File:
- 936727-05-8.mol
- MSDS File:
- SDS
Melting point | 200-205oC |
---|---|
Boiling point | 653.0±55.0 °C(Predicted) |
Density | 1.51 |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 3.95±0.10(Predicted) |
form | Solid |
color | White to Off-White |
InChIKey | UFSKUSARDNFIRC-UHFFFAOYSA-N |
SMILES | C(O)(=O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C5OC(F)(F)OC5=C4)CC3)=O)=CC=C2C)=C1 |
FDA UNII | EGP8L81APK |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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Lumacaftor (VX-809) price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 5mg | $151 | 2024-03-01 | Buy |
Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 10mg | $266 | 2024-03-01 | Buy |
Cayman Chemical | 22196 | VX-809 ≥98% | 936727-05-8 | 25mg | $573 | 2024-03-01 | Buy |
Usbiological | 273822 | VX-809 | 936727-05-8 | 50mg | $389 | 2021-12-16 | Buy |
Lumacaftor (VX-809) Chemical Properties,Uses,Production
Uses
VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.
Biological Activity
vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several
target
CFTR
Lumacaftor (VX-809) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. | +86-0311-67591193 +8613931880626 | sales02@dingminpharma.com | China | 252 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 260 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9312 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
View Lastest Price from Lumacaftor (VX-809) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | Lumacaftor
936727-05-8
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
2024-09-18 | Lumacaftor (VX-809)
936727-05-8
|
US $0.00 / g/Bag | 1g | 98.0%~102.0% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-08-15 | Lumacaftor (VX-809)
936727-05-8
|
US $0.00 / KG | 0.1KG | 98% | 1000KGS | Zhengzhou Anbu Chem Co.,Ltd |
- Lumacaftor
936727-05-8
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
- Lumacaftor (VX-809)
936727-05-8
- US $0.00 / g/Bag
- 98.0%~102.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Lumacaftor (VX-809)
936727-05-8
- US $0.00 / KG
- 98%
- Zhengzhou Anbu Chem Co.,Ltd