ChemicalBook >> CAS DataBase List >>(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

CAS No.
1032754-93-0
Chemical Name:
(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
Synonyms
CS-4;RG7422;GNE 390;GDC-0980;GDC-0981;Apitolisib;GDC-0980 (RG7422);RG7422 (Apitolisib);Apitolisib(GDC-0980);GDC-0980 (Apitolisib)
CBNumber:
CB32554362
Molecular Formula:
C23H30N8O3S
Molecular Weight:
498.6
MDL Number:
MFCD20274520
MOL File:
1032754-93-0.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:09

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Properties

Melting point >202°C (dec.)
Density 1.399
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.90±0.20(Predicted)
color White to Light Yellow
FDA UNII 1C854K1MIJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18303 GDC-0980 ≥98% 1032754-93-0 1mg $62 2024-03-01 Buy
Cayman Chemical 18303 GDC-0980 ≥98% 1032754-93-0 5mg $180 2024-03-01 Buy
Cayman Chemical 18303 GDC-0980 ≥98% 1032754-93-0 10mg $299 2024-03-01 Buy
Cayman Chemical 18303 GDC-0980 ≥98% 1032754-93-0 25mg $595 2024-03-01 Buy
TRC G303000 GDC-0980 1032754-93-0 100mg $770 2021-12-16 Buy
Product number Packaging Price Buy
18303 1mg $62 Buy
18303 5mg $180 Buy
18303 10mg $299 Buy
18303 25mg $595 Buy
G303000 100mg $770 Buy

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Chemical Properties,Uses,Production

Uses

GDC-0980 is used in the synthesis of PI3K inhibitors to treat carcinomas. Potent PI3K/mTOR dual Inhibitor.

Biological Activity

gdc-0980 (rg7422) is a selective, novel, potent and orally bioavailable inhibitor of class 1 pi3k/mtor kinase with the ki value of 17nmol/l for mtor kinase [1].gdc-0980 (rg7422) has shown the effective inhibition with the ic50 values of <200nmol/l in prostate, breast and nsclc lines, respectinely. in addition, gdc-0980 (rg7422) has been reported to reduce cell viability in kpl4 cells by cell-cycle inhibition and induction of apoptosis with the ic50 value of 109nm and the ec50 value of 78nm. furthermore, gdc-0980 (rg7422) has been revealed to significantly inhibit tumor responses in xenograft models in oral dose of the compound. besides, gdc-0980 (rg7422) has been noted to enhance the antitumor activity in combination with antitumor agents ( docetaxel) in vivo [1].

target

p110α

References

[1] wallin jj1, edgar ka, guan j, berry m, prior ww, lee l, lesnick jd, lewis c, nonomiya j, pang j, salphati l, olivero ag, sutherlin dp, o'brien c, spoerke jm, patel s, lensun l, kassees r, ross l, lackner mr, sampath d, belvin m, friedman ls. gdc-0980 is a novel class i pi3k/mtor kinase inhibitor with robust activity in cancer models driven by the pi3k pathway. mol cancer ther. 2011 dec;10(12):2426-36. doi: 10.1158/1535-7163.mct-11-0446. epub 2011 oct 13.

35265-88-4
1032754-93-0
Synthesis of (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one from Thieno[3,2-d]pyriMidine, 2-chloro-7-Methyl-4-(4-Morpholinyl)-
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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one pictures 2019-07-06 (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
1032754-93-0
US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Spectrum

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one GNE 390 GDC-0980 (S)-1-(4-((2-(2-aMinopyriMidin-5-yl)-7-Methyl-4-Morpholinothieno[3,2-d]pyriMidin-6-yl)Methyl)piperazin-1-yl)-2-hydroxypropan-1-one GDC-0980 (RG7422) RG7422 Apitolisib Apitolisib (GDC-0980, RG7422) (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one GNE 390 GDC0980(RG7422) GNE 390 (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Apitolisib(GDC-0980) RG7422 (Apitolisib) GDC-0981 GDC-0980 (RG7422);GNE 390; GDC 0980; RG 7422 (S)-1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)p (2S)-1-[4-[[2-(2-AMINOPYRIMIDIN-5-YL)-7-METHYL-4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-6-YL]METHYL]PIPERAZIN-1-YL]-2-HYDROXYPROPAN-1-ONE GDC-0980, 98%, a potent PI3K inhibitor GDC-0980 (Apitolisib, RG7422) GDC 0980 - RG 7422 | GNE 390 | Apitolisib GDC-0980; RG7422; RG-7422; GDC 0980; GNE 390;GDC0980. CS-4 1-Propanone, 1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-2-hydroxy-, (2S)- (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one USP/EP/BP GDC-0980 (Apitolisib) Apitolisib (GDC-0980, RG-7422, GNE-390) 1032754-93-0 C23H30N8O3S Akt mTOR PI3K Inhibitors PI3K/Akt/mTOR An inhibitor of Class I PI3 kinase and mTOR kinase.