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ChemicalBook >> CAS DataBase List >>2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Structure
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone structure
CAS No.
32384-65-9
Chemical Name:
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
Synonyms
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, δ-lactone;Dagliptin Impurity;oxy)-6-((triMethyL;Cagliflozin Impurity 9;Englitazinintermediate;Dapagliflozin Impurity 12;Canagliflozin Related Impurity 9;(3R,4S,5R,6R)-3,4,5-tris(triMethyL;Canagliflozin Impurity 9(Dagelin impurity 11)
CBNumber:
CB32610563
Molecular Formula:
C18H42O6Si4
Molecular Weight:
466.87
MDL Number:
MFCD22665922
MOL File:
32384-65-9.mol
MSDS File:
SDS
Last updated:2024-01-02 16:51:54
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2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Properties

Boiling point 417℃
Density 0.97
Flash point 171℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Oil
color Colourless to Pale Yellow
Stability Moisture Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P261-P280
HS Code  2931900090

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T279540 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 32384-65-9 5g $65 2021-12-16 Buy
TRC T279540 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 32384-65-9 50g $185 2021-12-16 Buy
Biosynth Carbosynth MT08101 2,3,4,6-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone 32384-65-9 10g $50 2021-12-16 Buy
Biosynth Carbosynth MT08101 2,3,4,6-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone 32384-65-9 50g $150 2021-12-16 Buy
ChemScene CS-M2269 (3R,4S,5R,6R)-3,4,5-Tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one >97.0% 32384-65-9 100g $76 2021-12-16 Buy
Product number Packaging Price Buy
T279540 5g $65 Buy
T279540 50g $185 Buy
MT08101 10g $50 Buy
MT08101 50g $150 Buy
CS-M2269 100g $76 Buy

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Chemical Properties,Uses,Production

Description

It is usually used as the intermediate and raw material in the chemistry synthesis and pharmaceutical industry. Especially, this chemical has been widely used in the design and synthesis of sodium-glucose transporter inhibitors.1 For example, this substance can be employed as raw material in the preparation of (1s)-1,5-anhydro-1-c-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol, which is commonly known as Dapagliflozin that act as the sodium dependent glucose transporters for treating type 2 diabetes.2 Moreover, it can also function as the intermediate for synthesizing empagliflozin, which is a novel and selective sodium glucose co-transporter-2 inhibitor.3 In addition, canagliflozin, another sodium glucose co-transporter-2 inhibitor, can be obtained by utilizing this substance as the intermediate.4

Uses

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.

Reference

  1. Guo, C.; Hu, M.; DeOrazio, R. J.; Usyatinsky, A.; Fitzpatrick, K.; Zhang, Z. J.; Maeng, J. H.; Kitchen, D. B.; Tom, S.; Luche, M.; Khmelnitsky, Y.; Mhyre, A. J.; Guzzo, P. R.; Liu, S., The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties. Bioorg. Med. Chem. 2014, 22, 3414-3422.
  2. S Thirumalai Rajan; Eswaraiah, S., Process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol and its solvate thereof. US Patent 2015, WO 2015/132803 A2.
  3. Hrapchak, M.; Latli, B.; Wang, X. J.; Lee, H.; Campbell, S.; Song, J. J.; Senanayake, C. H., Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13. J. Label. Compd. Radiopharm. 2014, 57, 687-694.
  4. Nomura, S.; Sakamaki, S.; Hongu, M.; Kawanishi, E.; Koga, Y.; Sakamoto, T.; Yamamoto, Y.; Ueta, K.; Kimata, H.; Nakayama, K.; Tsuda-Tsukimoto, M., Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. J. Med. Chem. 2010, 53, 6355-6360.

Chemical Properties

Pale yellow oil

Uses

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Preparation Products And Raw materials

Raw materials

Preparation Products

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Suppliers

Global( 455)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Shanghai Joiny Pharmaceutical Co.,LTD 		+8613681955282 gyd@joiny-pharma.com China 228 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Anhui Lianchuang Biological Medicine Co.,Ltd 		+8619355958469 sales7@lcywhx.com China 86 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Shanghai Joiny Pharmaceutical Co.,LTD 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Hangzhou ICH Biofarm Co., Ltd 		58
Anhui Lianchuang Biological Medicine Co.,Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55

View Lastest Price from 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone pictures 2024-04-10 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
32384-65-9
 US $0.00 / kg 1kg 95% 500kg Shanghai Joiny Pharmaceutical Co.,LTD
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone pictures 2024-04-10 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
32384-65-9
 US $0.00 / kg 1kg 90% 300kg Shanghai Joiny Pharmaceutical Co.,LTD
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone pictures 2024-04-10 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
32384-65-9
 US $0.00 / kg 1kg 98% 500kg Shanghai Joiny Pharmaceutical Co.,LTD

32384-65-9(2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone)Related Search:

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 5-bromo-2-chloro-4’-ethoxydiphenylmethane (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran 4-(5-broMo-2-chlorobenzyl)phenol Acarbose
5-Bromo-2-methylbenzoic acid D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI) (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 5-Bromo-2-methylbenzoyl chloride
5-Iodo-2-methylbenzoic acid Canagliflozin heMihydrate LIPOPHILIC SEPHADEX 2-(4-Fluorophenyl)-thiophene BCP19353
Canagliflozin 5-Bromo-2-chlorobenzoic acid (5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone

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(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one (3R,4S,5R,6R)-3,4,5-Tris[(trimethylsilyl)oxy]-6-[[(trimethylsilyl)oxy]methyl]tetrahydropyran-2-one D-2,3,4,6-Tetrakis-O-(trimethylsilyl)-gluconic acid delta-lactone 2,3,4,6-Tetrakis-O-triMethylsilyl-D-gluconolactoe D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, d-lactone 2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono1,5 lactone (3R,5R,6R)-3,4,5-Tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan-2-one 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone Dapagliflozin Impurity 12 Cagliflozin Impurity 9 32384-65-9 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan-2-one 32384-65-9 (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyl)oxy)-6-((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 97% 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-delta-lactone (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan Dagliptin Impurity (3R,4S,5R,6R)-3,4,5-tris(triMethyL oxy)-6-((triMethyL Canagliflozin Related Impurity 9 2,3,4,6, tetrakis-O-(trimethylsilyl)-D-lactone, 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone(For export only) (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ISO 9001：2015 REACH Empagliflozin intermediates，2,3,4,6-Tetrakis-O-trimethylsilyl-D- gluconolactone 2,3,4,5-Tetrakis-O-trimethylsilyl-D-gluconolactone 5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one D-Gluconic acid, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, .delta.-lactone 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactoneQ: What is 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone Q: What is the CAS Number of 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone Q: What is the storage condition of 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone Q: What are the applications of 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, δ-lactone 3,4,5-Tris[(trimethyl silyl)oxy]-6-{[(trimethylsilyl)oxy]methyl}tetrahydro-2H-pyron-2-one Englitazinintermediate Boronicacid,B-(1,6-dihydro-6-oxo-9-pyridinyl)- (3R,4S,5R,6R)-3,4,5-tri ((trimethyl) Methylsilane)oxy)-6-(((trimethylmethylmethyl Silic alkyl)oxy group) field group) four atmosphere-2H-pyrid N?m-2-ketone (3R, 4S, 5R, 6R)-3,4,5-tri ((trimethyl)Methylsilane)oxy)-6-(((trimethylmethylmethyl Silicyl)oxy)methyl)tetrahydr-2H-pyridium N?m-2-ketone (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one,95% 2,3,4,6- tetra -O- trimethylsilyl -D- gluconolactone D-Gluconic acid, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, δ-lactone (3R,4S,5R,6R)-3,4,5-tris(TMS-oxy)-6-[(TMS-oxy)methyl]tetrahydro-2H-pyran-2-one/D-Gluconic acid, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, δ-lactone 2,3,4,6-tetra-O-Trimethylsilyl-beta-D-glucolactone Canagliflozin Impurity 9(Dagelin impurity 11) 2,3,4,6-tetra-O-trimethylsilyl-β-d- gluconolactone (3R,4S,5R,6R)-3,4,5- Tri[(trimethylsilyl)oxy]-6- [[(Trimethylsilyl)oxy] methyl]tetrahydro-2H-pyran- 2-one 2,3,4,6-tetra-O-Trimethyl silyl-beta-D-glucolacto Commercial 32384-65-9 32384-69-5 C18H42O6Si4 32384-65-9