ChemicalBook >> CAS DataBase List >>RG-7388
RG-7388
- CAS No.
- 1229705-06-9
- Chemical Name:
- RG-7388
- Synonyms
- Idasanutlin;RG7388;Pexidartinib Hydrochloride;RG-7388;RG 7388;Ro 5503781;RG-7388 USP/EP/BP;RG-7388, Idasanutlin;Idasanutlin (RG-7388);RG 7388; RG-7388; RG7388
- CBNumber:
- CB32666681
- Molecular Formula:
- C31H29Cl2F2N3O4
- Molecular Weight:
- 616.48
- MDL Number:
- MFCD26142931
- MOL File:
- 1229705-06-9.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | >261° (dec.) |
|---|---|
| Boiling point | 737.3±60.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.11±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| NCI Dictionary of Cancer Terms | pexidartinib hydrochloride |
| FDA UNII | QSQ883V35U |
| NCI Drug Dictionary | idasanutlin |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
RG-7388 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21532 | RG7388 ≥98% | 1229705-06-9 | 1mg | $47 | 2024-03-01 | Buy |
| Cayman Chemical | 21532 | RG7388 ≥98% | 1229705-06-9 | 5mg | $206 | 2024-03-01 | Buy |
| Cayman Chemical | 21532 | RG7388 ≥98% | 1229705-06-9 | 10mg | $339 | 2024-03-01 | Buy |
| Cayman Chemical | 21532 | RG7388 ≥98% | 1229705-06-9 | 25mg | $564 | 2024-03-01 | Buy |
| Tocris | 6904 | Idasanutlin ≥98%(HPLC) | 1229705-06-9 | 50 | $609 | 2021-12-16 | Buy |
RG-7388 Chemical Properties,Uses,Production
Description
Potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.
Uses
Idasanutlin is an MDM2 inihibtor, blocking the p53 protein-protein interaction and may be used in anti-cancer treatments.
storage
Store at -20°C
Synthesis of RG-7388 from (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile and Benzoic acid, 4-[[2-[(E)-(3,3-dimethylbutylidene)amino]acetyl]amino]-3-methoxy-, methyl ester
RG-7388 Preparation Products And Raw materials
Global( 138)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
1229705-06-9(RG-7388)Related Search:
4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid
RG 7388
RG-7388
RG-7388, Idasanutlin
Idasanutlin (RG-7388)
4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimet
RG 7388; RG-7388; RG7388
4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid
Ro 5503781
Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-
4-{[(3s,4r,5s)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-D-prolyl]amino}-3-methoxybenzoic acid
RG-7388 USP/EP/BP
4-[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-amido]-3-methoxybenzoic acid
Idasanutlin
RG7388
Pexidartinib Hydrochloride
4-((2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid
4-{(3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(2-fluoro-4-chlorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-D-prolylamino}-3-methoxy-benzoic acid
1229705-06-9
C31H29Cl2F2N3O4
Inhibitors