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CAS No. 35943-35-2
Chemical Name: API-2
CBNumber: CB3270000
Molecular Formula: C13H16N6O4
Formula Weight: 320.3
MOL File: 35943-35-2.mol
API-2 Property
storage temp. : Store at RT
solubility : DMSO: >10mg/mL
color : tan
RTECS : RY8455000

API-2 Chemical Properties,Usage,Production

Chemical Properties
Off-White Solid
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
Biological Activity
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
API-2 Preparation Products And Raw materials
Raw materials
Preparation Products
API-2 Suppliers      Global( 55)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Wuhan HengHeDa Pharm Co., Ltd. 027-84888681 Mobile:18086046872
027-84888682 QQ: 2461625847 China 1910 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96831 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 China 15950 69
Chemsky(shanghai)International Co.,Ltd. 021-50135380 China 32539 50
Jinan Trio PharmaTech Co., Ltd. +86 (531) 88811783;
+86 (531) 55696010 QQ 1762738062 (International market); market) China 1805 62
Wuhan Vanzpharm Inc. +86-027-84492310, +86-13657243668
+86-027-84492310, QQ2742940232 China 160 58
BOC Sciences 1-631-504-6093
1-631-614-7828 United States 10012 65
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 China 4840 58
T&W GROUP +86-21-61551611, 61551462, 61551420, 61551610
+86-21-50676805 China 13377 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
+86-27-87599188 China 1502 55
35943-35-2(API-2)Related Search:
G1969-85001 API-TOF-REFERENCE MASS apoptosis inhibitor API5L1 ACTIVE PHARMACEUTICAL INGREDIENTS (API) MULTIPLIER PE-SCIEX API2000 SULPHATE REDUCING AGAR ACC. TO API API Api m 6 allergen API SOURCING PROJECT Api g 1 protein Api & Chiral Compounds API-59CJ-OME HYDRATE API CONTROL API2-MALT1 fusion protein 7-DEAZA-2'-DEOXYADENOSINE API-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine triciribine phosphate,Triciribine 5'-phosphate TUBERCIDIN
API-2 35943-35-2 6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE AKT/PKB SIGNALING INHIBITOR-2 AKT INHIBITOR V 1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE 1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura 1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof 3-amine 3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap 4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1 hthylene nosyl- pentaazacentopthylene uranosyl- TRICYCLIC NUCLEOSIDE TRICIRIBINE NSC 154020 TCN API-2 (Tricirbine) Protein Kinase 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine (1,4,5,6,8-Pentaazaacenaphthylen-3-aMine,1,5-dihydro-5-Methyl-1-b-D-ribofuranosyl-) 6-AMino-4-Methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyriMido[4,5-c]pyridazine (2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol VD-0002 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine Triciribine 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Inhibitor V Triciribine hydrate ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit BIRC3 IAP1 MIHC RNF49 ANTI-MYO1A (CENTER S291) antibody produced in rabbit Brush border myosin I MYHL Myosin-Ia Anti-MYO1A antibody produced in rabbit BBMI DFNA48 MYO1A Anti-Dfna48 Anti-Myhl Anti-Myosin ia Triciribine, >=98% Inhibitors (1R,2S,3R,5R)-3-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)c InSolution? Akt Inhibitor V, Triciribine Akt mTOR PI3K
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