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Tamsulosin hydrochloride

Tamsulosin hydrochloride Structure
Tamsulosin hydrochloride structure
CAS No.
106463-17-6
Chemical Name:
Tamsulosin hydrochloride
Synonyms
TAMSULOSIN HCL;SOY ISOFLAVONE;FLOMAX;(R)-TaMsulosin;Omic;OMNIC;PRADIF;YM-617;Yutana;HARNAL
CBNumber:
CB3410080
Molecular Formula:
C20H29ClN2O5S
Molecular Weight:
444.97
MDL Number:
MFCD00922997
MOL File:
106463-17-6.mol
MSDS File:
SDS
Last updated:2024-03-14 18:29:10
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Tamsulosin hydrochloride Properties

Melting point 228-230°C
alpha D24 -4.0° (c = 0.35 in methanol)
RTECS DB2430000
storage temp. 2-8°C
solubility DMSO: >10mg/mL
form white powder
color White to Off-White
Merck 14,9049
InChIKey ZZIZZTHXZRDOFM-XFULWGLBSA-N
CAS DataBase Reference 106463-17-6(CAS DataBase Reference)
NCI Dictionary of Cancer Terms Flomax; tamsulosin hydrochloride
FDA UNII 11SV1951MR
NCI Drug Dictionary Flomax

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
HS Code  29350090
NFPA 704
0
3 0

Tamsulosin hydrochloride price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1524 Tamsulosin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 106463-17-6 200mg $383 2024-03-01 Buy
Sigma-Aldrich 1643260 Tamsulosin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 106463-17-6 200mg $4200 2024-03-01 Buy
Sigma-Aldrich BP876 Tamsulosin hydrochloride British Pharmacopoeia (BP) Reference Standard 106463-17-6 100MG $259 2023-06-20 Buy
TCI Chemical T2749 Tamsulosin Hydrochloride >98.0%(HPLC)(T) 106463-17-6 100mg $50 2024-03-01 Buy
TCI Chemical T2749 Tamsulosin Hydrochloride >98.0%(HPLC)(T) 106463-17-6 1g $244 2024-03-01 Buy
Product number Packaging Price Buy
PHR1524 200mg $383 Buy
1643260 200mg $4200 Buy
BP876 100MG $259 Buy
T2749 100mg $50 Buy
T2749 1g $244 Buy

Tamsulosin hydrochloride Chemical Properties,Uses,Production

Description

Tamsulosin hydrochloride is the hydrochloride form of Tamsulosin (Trade name: Alna ® / Flomax ®). It is a kind of medication used for the treatment of symptomatic benign prostatic hyperplasia (BPH), boosting the passage of kidney stones. It can also be used for the treatment of acute urinary retention. It is a kind of selective antagonist of alpha-1A and alpha-1B-adrenoceptros located in prostate, prostatic capsule, prostatic urethra, and bladder neck. The blockage of these receptors through Tamsulosin causes the relaxation of smooth muscles in the bladder neck and prostate.

References

https://www.drugbank.ca/drugs/DB00706
https://en.wikipedia.org/wiki/Tamsulosin

Description

Tamsulosin is a potent antagonist of α1-adrenergic receptors (α1-ARs; Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F2α . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.

Chemical Properties

White to Off-White Solid

Originator

Contiflo OD,Ranbaxy Laboratories,India

Uses

An α1-adrenoceptor antagonist

Uses

(R)-Tamsulosin is a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.

Uses

Specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

Uses

antineoplastic, alkylating agent

Uses

Specific a1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy

Definition

ChEBI: Tamsulosin hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of tamulosin and hydrogen chloride. It has a role as an alpha-adrenergic antagonist and an antineoplastic agent. It contains a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin hydrochloride.

Manufacturing Process

In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2- ethoxyphenoxy)ethylamino]-1-hydroxy-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride and while stirring the suspension, 9 g of thionyl chloride was added dropwise to the suspension at room temperature, whereby the product first dissolved and then began to crystallize gradually. After stirring the mixture for two days, the crystals formed were recovered by filtration, washed with chloroform and dried to provide 15 g of 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride. Melting point: 197°-200°C.
In methanol was dissolved the 5-{1-chloro-2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide hydrochloride and after adding thereto 10% palladium carbon, dechlorination was performed under hydrogen stream at normal temperature and pressure. The palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide the 2-methoxy-5-{2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by volume ratio) to provide the colorless crystals thereof. The melting point of the 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride: 254°-256°C.

Therapeutic Function

Antihypertensive

General Description

Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

Hazard

Moderately toxic by ingestion.

Biological Activity

Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .

Biochem/physiol Actions

Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

storage

Desiccate at RT

Tamsulosin hydrochloride synthesis

852619-17-1
106463-17-6
106133-20-4
Synthesis of Tamsulosin hydrochloride from Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]imino]propyl]-2-methoxy-

Tamsulosin hydrochloride Preparation Products And Raw materials

Raw materials

Thionyl chloride Hydrogen Palladium hydroxide Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]imino]propyl]-2-methoxy- Tamsulosin

Preparation Products

Tamsulosin hydrochloride Suppliers

Global( 445)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Guangzhou Tengyue Chemical Co., Ltd. 		+86-86-18148706580 +8618826483838 evan@tyvovo.com China 152 58
Sigma Audley 		+86-18336680971 +86-18126314766 nova@sh-teruiop.com China 525 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2141 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Guangzhou Tengyue Chemical Co., Ltd. 		58
Sigma Audley 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Xiamen AmoyChem Co., Ltd 		58
BOC Sciences 		58

View Lastest Price from Tamsulosin hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tamsulosin hydrochloride pictures 2024-03-15 Tamsulosin hydrochloride
106463-17-6
 US $35.00-25.00 / kg 1kg 99.8% 200tons/year Sigma Audley
Tamsulosin hydrochloride pictures 2023-12-23 Tamsulosin hydrochloride
106463-17-6
 US $90.00 / kg 1kg 99% Purity (What/sapp: +86 18145728414) 1000 Tons/Month Guangzhou Tengyue Chemical Co., Ltd.
Tamsulosin hydrochloride pictures 2023-09-13 Tamsulosin hydrochloride
106463-17-6
 US $50.00 / kg 1kg 0.99 10000 Hebei Yanxi Chemical Co., Ltd.
  • Tamsulosin hydrochloride pictures
  • Tamsulosin hydrochloride
    106463-17-6
  • US $90.00 / kg
  • 99% Purity (What/sapp: +86 18145728414)
  • Guangzhou Tengyue Chemical Co., Ltd.

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1of4

(R)-(-)-5-[2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzolsulfonamid hydrochloride 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamidehydrochloride TaMsulosin Hydrochloride, EP Tamsulosin Hydrochloride (200 mg) 5-[(R)-2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride (S)-5-(2-((2-(2-ethoxyphenoxy)ethyl)aMino)propyl)-2-MethoxybenzenesulfonaMide TAMSULOSIN HYDRCHLORIDE Harnal,YM 617, AMsulosin TaMsulosin hydrochlorid TAMSOLUSIN HYDROCHLORIDE PRADIF OMNIC YM-12617-1 YM-617 (-)-ly253352 (-)-ym12617 (R)-Tamsulosin Hydrochloride 5-[(2R)-2-[[2-(-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride Yutana TAMSULOSINHYDROCHLORIDE(SUBJECTTOPATENTFREE) TAMSOLUSINHCL (R)-(-)-YM 12617 Benzenesulfonamide, 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride (9CI) Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride, (R)- Omic 5-[(2R)-2-[[2-(2-ETHOXYPHENOXY)ETHYL]AMINO]PROPYL]-2-METHOXYBENZENESULFONAMIDE HYDROCHLORIDE TAMSULOSIN, HYDROCHLORIDE 99.5% Tamsulosin hydrochloride Yutanal 5-[2-[[2-(-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride rac Tamsulosin Hydrochloride (r)-onohydrochlorid 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-,monohydrochloride,(r)-benzenesulfonamid 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-benzenesulfonamidm amsulosinhydrochloride idehydrochloride r-(-)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonam LY-253351 HARNAL Flomax hydrochloride Tamsulosin hydrochloride, 98%, Potent, selective α1A antagonist (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride CS-1361 Tamsulosin, LY 253351 Tamsulosin racemate CRS Tamsulosin hydrochloride CRS Tamsulosin hydrochloride USP/EP/BP Tamsulosin hydrochloride salt Tamsulosin Hydrochloride (R041N0) Tamsulosin Hydrochloride (1643260) (R)-TaMsulosin TAMSULOSIN HCL SOY ISOFLAVONE FLOMAX TAMSULOSIN HCL 0.2% SR , 0.16% SR PELLETS 106463-17-6 C20H28N2O5SHCl C20H29ClN2O5S