4-Bromobenzonitrile
- CAS No.
- 623-00-7
- Chemical Name:
- 4-Bromobenzonitrile
- Synonyms
- P-BROMOBENZONITRILE;4-cyanobromobenzene;1-Bromo-4-cyanobenzene;4-bromobenzoic acid nitrile;PBBN;Of broMoxynil;4-Brombenzonitril;4-bromo-benzonitril;p-Cyanobromobenzene;BROMOBENZONITRILE-4
- CBNumber:
- CB3423145
- Molecular Formula:
- C7H4BrN
- Molecular Weight:
- 182.02
- MDL Number:
- MFCD00001811
- MOL File:
- 623-00-7.mol
- MSDS File:
- SDS
| Melting point | 110-115 °C(lit.) |
|---|---|
| Boiling point | 235-237 °C(lit.) |
| Density | 1,562 g/cm3 |
| refractive index | 1.5999 (estimate) |
| Flash point | 130°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 0.2g/l |
| form | Powder or Flakes |
| color | White to light yellow or flakes |
| Water Solubility | Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether. |
| BRN | 2041518 |
| InChIKey | HQSCPPCMBMFJJN-UHFFFAOYSA-N |
| LogP | 2.3 at 22.5℃ and pH7 |
| CAS DataBase Reference | 623-00-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 32L8XG37J4 |
| NIST Chemistry Reference | 4-Bromobenzoic acid nitrile(623-00-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312-H319-H412 | |||||||||
| Precautionary statements | P264-P273-P280-P301+P312-P302+P352+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 61-36/37/39-26-24/25 | |||||||||
| RIDADR | UN 3439 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DI2460000 | |||||||||
| Hazard Note | Toxic/Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269095 | |||||||||
| NFPA 704 |
|
4-Bromobenzonitrile price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B58407 | 4-Bromobenzonitrile 99% | 623-00-7 | 10g | $53.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | B58407 | 4-Bromobenzonitrile 99% | 623-00-7 | 50g | $168 | 2024-03-01 | Buy |
| TCI Chemical | B1426 | 4-Bromobenzonitrile >97.0%(GC) | 623-00-7 | 25g | $49 | 2024-03-01 | Buy |
| TCI Chemical | B1426 | 4-Bromobenzonitrile >97.0%(GC) | 623-00-7 | 250g | $488 | 2024-03-01 | Buy |
| Alfa Aesar | A10914 | 4-Bromobenzonitrile, 98+% | 623-00-7 | 10g | $44.65 | 2024-03-01 | Buy |
4-Bromobenzonitrile Chemical Properties,Uses,Production
Chemical Properties
4-Bromobenzonitrile is white to light yellow powder or flakes
Uses
4- Bromobenzonitrile is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceu ticals and other organic chemicals,
Uses
4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides.
Synthesis Reference(s)
Tetrahedron Letters, 27, p. 1925, 1986 DOI: 10.1016/S0040-4039(00)84413-5
Synthesis
To a 10 mL glass tube aryl halide (1 mmol), K4FeCN6 (0.6 mmol,220 mg), K2CO3 (1.5 mmol, 207 mg), catalyst (10 mg), and 2 mL DMF were added and the mixture was stirred for appropriate reaction time at 120 ℃ under argon atmosphere. The progress of the reaction was monitored by GC analysis. After completion of the reaction, the reaction mixture was washed with 5 mL water, and the crude product was isolated using dichloromethane (5× 1 mL). Organic extracts were combined, evaporated, and purified by flash chromatography using hexane/EtOAc to give 4-Bromobenzonitrile.
4-Bromobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9350 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com | jocelynpan@zjarts.com | CHINA | 993 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
View Lastest Price from 4-Bromobenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-31 | 4-Bromobenzonitrile
623-00-7
|
US $100.00 / bag | 1bag | 99 | 5000 | Hebei Fengqiang Trading Co., LTD | |
 |
2023-05-25 | 4-Bromobenzonitrile
623-00-7
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2023-01-31 | 4-Bromobenzonitrile
623-00-7
|
US $0.00 / ASSAYS | 1ASSAYS | 99% | 20ton | Hebei Mojin Biotechnology Co., Ltd |
-
- 4-Bromobenzonitrile
623-00-7
- US $100.00 / bag
- 99
- Hebei Fengqiang Trading Co., LTD
-
- 4-Bromobenzonitrile
623-00-7
- US $9.00 / KG
- 99.9
- Hebei Guanlang Biotechnology Co,.LTD
-
- 4-Bromobenzonitrile
623-00-7
- US $0.00 / ASSAYS
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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