Polysorbate 20
- CAS No.
- 9005-64-5
- Chemical Name:
- Polysorbate 20
- Synonyms
- TWEEN 20;SORBITAN MONOLAURATE;capmul;PEG-80 SORBITAN LAURATE;Polisorbate 20- PS 20;POLYSORBATE 21;POLYOXYETHYLENE SORBITAN MONOLAUREATE;POLYETHYLENE GLYCOL SORBITAN MONOLAURATE;POLYOXYETHYLENE (20) SORBITAN MONOLAURATE;Tween 20 (Trademark of ICI America, Inc.)
- CBNumber:
- CB3462544
- Molecular Formula:
- C26H50O10
- Molecular Weight:
- 522.6692
- MDL Number:
- MFCD00165986
- MOL File:
- 9005-64-5.mol
- MSDS File:
- SDS
| Melting point | 98.9 °C (decomp) |
|---|---|
| Boiling point | 100 °C |
| Density | 1.11 g/mL at 20 °C |
| vapor pressure | <1.4 hPa (20 °C) |
| FEMA | 2915 | POLYSORBATE 20 |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | 100 g/L |
| form | viscous liquid |
| Specific Gravity | 1.090～1.130 (20/20℃) |
| color | Amber |
| PH | 6-8 (50g/l, H2O, 20℃) |
| PH Range | 7 |
| Odor | mild alcohol odor |
| Odor Type | alcoholic |
| Water Solubility | 100 g/L |
| Hydrophilic-Lipophilic Balance (HLB) | 16.7 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Substances Added to Food (formerly EAFUS) | POLYSORBATE 20 |
| EWG's Food Scores | 3-8 |
| FDA UNII |
PEG-80 SORBITAN LAURATE (239B50Y732) PEG-75 SORBITAN LAURATE (31JQ3WOL8T) PEG-10 SORBITAN LAURATE (4Z93U4C2WN) POLYSORBATE 21 (59IO08SBZU) POLYSORBATE 20 (7T1F30V5YH) |
| EPA Substance Registry System | Polysorbate 20 (9005-64-5) |
| Cosmetics Info | Polysorbate 20 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338-P362+P364 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22-36/37/38-37/38-41 | |||||||||
| Safety Statements | 24/25-36/37/39-36-26 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | TR7400000 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 34021300 | |||||||||
| Toxicity | LD50 orally in Rabbit: 38900 mg/kg | |||||||||
| NFPA 704 |
|
Polysorbate 20 price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P7949 | TWEEN® 20 BioXtra, viscous liquid | 9005-64-5 | 2.5L | $293 | 2024-03-01 | Buy |
| Sigma-Aldrich | P1379 | TWEEN® 20 viscous liquid | 9005-64-5 | 1KIT | $137 | 2024-03-01 | Buy |
| Sigma-Aldrich | 9480-OP | TWEEN® 20 | 9005-64-5 | 1L | $98.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.22184 | TWEEN® 20 for synthesis | 9005-64-5 | 50mL | $32.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.22184 | TWEEN® 20 for synthesis | 9005-64-5 | 500mL | $49.2 | 2024-03-01 | Buy |
Polysorbate 20 Chemical Properties,Uses,Production
Description
Tween 20, whose common commercial names includes Alkest TW 20 and Polysorbate 20, is a mild nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid which is a medium-chain fatty acid found mainly in coconut oil. It is allowed to be used as the emulsifier, detergent, dispersant, solvent and stabilizer, etc. in a number of fields such as pharmaceutical, chemical, food, textile and other industries due to its stability and relative non-toxicity.
Tween 20 is widely applied in biological techniques and sciences, which can be added to buffers and reagents for immunohistochemistry, such as Western blots and ELISAs, helping to prevent non-specific antibody binding, decrease background staining and enhance reagent spreading. Besides, Tween 20 also has applications in food production as a common food grade additive which are found in many consumables on the market today. It can also be used as a wetting agent in flavored mouth drops such as Ice Drops, in oral or non-gastrointestinal suspensions and in rubber balers in the elastomer industry.
References
https://en.wikipedia.org/wiki/Polysorbate_20
http://www.organic-creations.com/thickeners-stabilizers/599-polysorbate-20
Chemical Properties
Yellow liquid
Chemical Properties
Polysorbate 20 is a mixture of laurate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides. It has a faint, characteristic odor and a warm, somewhat bitter taste.
Uses
polysorbate 20 is a solubilizer, emulsifier, viscosity modifier, and stabilizer of essential oils in water.
Uses
Used for solubilizing membrane proteins during isolation and purification.Polysorbate 20 is used as a wetting agent in flavored mouth drops. It acts as a washing agent in Western blots and ELISAs and prevents antibody binding. It is a solubilizing agent of membrane proteins. In pharmaceutical chemistry, it is used as an excipient to stabilize emulsions and suspensions. Further, it is used as a dispersing agent, stabilizer, lubricator and also used in creams, salves, ointments, protective creams, balms, pomades, lipsticks, mascaras and glosses.
Definition
ChEBI: Polysorbate 20 (Tween 20) is a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a dodecanoyl group. It is a surfactant and emulsifier used in cleaners and personal care products.
Preparation
polysorbate 20 is prepared by condensing the partial esters of sorbitol and its anhydrides with ethylene oxide to effect an oxyethylene copolymerization at the free hydroxyl groups.
brand name
Tween 20 (ICI Americas).
General Description
Polysorbate 20 is a hydrophilic nonionic surfactant generally used as emulsifiers, dispersing agent and solubilizer.
Health effects
Polysorbate 20 was a skin irritant in dermatitis patients but was reported not to induce irritant responses when applied to the intact skin of health volunteers. It produced, at worst, minimal irritation in the eyes of rabbits. Only a small number of cases of skin sensitization have been reported in humans, although a moderate to strong sensitizing potential was seen in guinea-pigs treated by intradermal injection.
Flammability and Explosibility
Non flammable
Safety Profile
Moderately toxic by intravenous route. Mddly toxic by ingestion. A human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Polysorbate 20 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 893 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 2259 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Related articles
- The preparation method of polysorbate 20
- Polysorbate 20 is a commonly used excipient in biopharmaceutical formulations, some of which may have an enzymatic activity
- Apr 8，2022
View Lastest Price from Polysorbate 20 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Polysorbate 20
9005-64-5
|
US $32.00 / kg | 1kg | 99% | 5000kg/week | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-04-26 | Tween 20 / Polysorbate 20
9005-64-5
|
US $6.00 / KG | 100KG | 99% | 1000kg | Hebei Yime New Material Technology Co., Ltd. | |
 |
2024-04-20 | Polysorbate 20
9005-64-5
|
US $3.00 / kg | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Polysorbate 20
9005-64-5
- US $32.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Tween 20 / Polysorbate 20
9005-64-5
- US $6.00 / KG
- 99%
- Hebei Yime New Material Technology Co., Ltd.
-
- Polysorbate 20
9005-64-5
- US $3.00 / kg
- 99.92%
- Ouhuang Engineering Materials (Hubei) Co., Ltd