Chelerythrine
- CAS No.
- 34316-15-9
- Chemical Name:
- Chelerythrine
- Synonyms
- Cheleritrine;helerythrine;CHELERYTHRINE;Einecs 251-930-0;Broussonpapyrine;Chelerythrine (6CI);478-03-5 (Hydroxide);3895-92-9 (Chloride);Chelerythrine chlori;Chelerythrine chloride
- CBNumber:
- CB3506907
- Molecular Formula:
- C21H18NO4+
- Molecular Weight:
- 348.37192
- MDL Number:
- MFCD00270393
- MOL File:
- 34316-15-9.mol
- MSDS File:
- SDS
| Melting point | 195-205°C |
|---|---|
| Boiling point | 496.37°C (rough estimate) |
| Density | 1.2985 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| storage temp. | Desiccate at -20°C |
| solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly） |
| form | Solid |
| color | Light Yellow to Dark Orange |
| Stability | Hygroscopic |
| LogP | -0.401 (est) |
| CAS DataBase Reference | 34316-15-9(CAS DataBase Reference) |
| FDA UNII | E3B045W6X0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H315-H319-H335 |
| Precautionary statements | P261-P264-P301+P310+P330-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
Chelerythrine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1330 | Chelerythrine chloride ≥98%(HPLC) | 34316-15-9 | 5 | $159 | 2021-12-16 | Buy |
| Usbiological | 044663 | Chelerythrine chloride | 34316-15-9 | 1mg | $269 | 2021-12-16 | Buy |
| Usbiological | 169656 | Chelerythrine Chloride | 34316-15-9 | 5mg | $340 | 2021-12-16 | Buy |
| Usbiological | 254958 | Chelerythrine chloride | 34316-15-9 | 5mg | $403 | 2021-12-16 | Buy |
| Usbiological | C3889-10 | Chelerythrine Chloride | 34316-15-9 | 5mg | $216 | 2021-12-16 | Buy |
Chelerythrine Chemical Properties,Uses,Production
Description
Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.
References
https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ
Uses
Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.
Definition
ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Biological Activity
Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.
Purification Methods
Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.
Chelerythrine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from Chelerythrine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | Chelerythrine; Chelerythrine chloride
34316-15-9
|
US $0.00 / KG | 1KG | 1%-98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2023-02-24 | Chelerythrine
34316-15-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2021-07-02 | chelerythrine
34316-15-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Chelerythrine; Chelerythrine chloride
34316-15-9
- US $0.00 / KG
- 1%-98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Chelerythrine
34316-15-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- chelerythrine
34316-15-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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