ChemicalBook >> CAS DataBase List >>Betamethasone 17,21-dipropionate
Betamethasone 17,21-dipropionate
- CAS No.
- 5593-20-4
- Chemical Name:
- Betamethasone 17,21-dipropionate
- Synonyms
- BETAMETHASONE DIPROPIONATE;BetaMethasone dipropionat;diprolene;diprosone;Betamethasone 17;S 3440;Psorion;Maxivate;diprosis;Diprophos
- CBNumber:
- CB3676725
- Molecular Formula:
- C28H37FO7
- Molecular Weight:
- 504.6
- MDL Number:
- MFCD00072035
- MOL File:
- 5593-20-4.mol
- MSDS File:
- SDS
Last updated:2024-04-19 20:05:26
| Melting point | 178 °C |
|---|---|
| alpha | D26 +65.7° (dioxane) |
| Boiling point | 603.2±55.0 °C(Predicted) |
| Density | 1.1481 (estimate) |
| refractive index | 69 ° (C=1, Dioxane) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent). |
| pka | 12.87±0.70(Predicted) |
| color | White to Pale Yellow |
| Merck | 1180 |
| InChIKey | CIWBQSYVNNPZIQ-JCOVECCMSA-N |
| SMILES | C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r| |
| CAS DataBase Reference | 5593-20-4(CAS DataBase Reference) |
| FDA UNII | 826Y60901U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H373 |
| Precautionary statements | P202-P260-P280-P308+P313-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | TU4058000 |
| HS Code | 29372290 |
| Toxicity | LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82 |
Betamethasone 17,21-dipropionate price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B1152 | Betamethasone 17,21-dipropionate ≥97.0% | 5593-20-4 | 1g | $276 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1067704 | Betamethasone dipropionate | 5593-20-4 | 125mg | $358 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0001925 | Betamethasone dipropionate for system suitability A European Pharmacopoeia (EP) Reference Standard | 5593-20-4 | Y0001925 | $212 | 2023-06-20 | Buy |
| Sigma-Aldrich | Y0001416 | Betamethasone dipropionate for peak identification European Pharmacopoeia (EP) Reference Standard | 5593-20-4 | y0001416 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | B1152 | Betamethasone 17,21-dipropionate ≥97.0% | 5593-20-4 | 100mg | $53.4 | 2024-03-01 | Buy |
Betamethasone 17,21-dipropionate Chemical Properties,Uses,Production
Chemical Properties
Betamethasone 17,21-dipropionate is Pale Yellow Foam
Originator
Betnovate,Glaxo,UK,1961
Uses
Cortico Steroids
Uses
antiviral
Uses
Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.
Definition
Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.
Manufacturing Process
A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'-
ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid
(20 ml), containing 2 drops of water, was allowed to stand at room
temperature for 5 hours. Dilution of the mixture with water gave a white solid
(457 mg) which, after being filtered off and dried, was recrystallized from
acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α-
propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with
propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and
acidification with dilute hydrochloric acid gave the crude diester.
Recrystallization from acetone-petroleum ether afforded betamethasone
17,21-dipropionate (649 mg), MP 117°C (decomposition).
brand name
Alphatrex (Savage); Diprolene (Schering).
Therapeutic Function
Glucocorticoid
Biochem/physiol Actions
Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.
Safety Profile
Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.
Synthesis of Betamethasone 17,21-dipropionate from (11β,16β)-9-BroMo-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
Betamethasone 17,21-dipropionate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 410)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| APOLLO HEALTHCARE RESOURCES | +6596580999 | sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| Hebei Dangtong Import and export Co LTD | +8615632927689 | admin@hbdangtong.com | China | 991 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8619133911216 | fanfan@kangcang.com.cn | China | 338 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-13474506593 +86-13474506593 | sarah@tnjone.com | China | 874 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
View Lastest Price from Betamethasone 17,21-dipropionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | Betamethasone Dipropionate
5593-20-4
|
US $20.00-10.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-25 | Betamethasone Dipropionate
5593-20-4
|
US $9.00-60.00 / g | 10g | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-24 | Betamethasone 17,21-dipropionate
5593-20-4
|
US $10.00-1.00 / kg | 2kg | 99% | 300tons | Hebei Dangtong Import and export Co LTD |
-
- Betamethasone Dipropionate
5593-20-4
- US $20.00-10.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD
-
- Betamethasone Dipropionate
5593-20-4
- US $9.00-60.00 / g
- 99%
- Hebei Kangcang new material Technology Co., LTD
-
- Betamethasone 17,21-dipropionate
5593-20-4
- US $10.00-1.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD
5593-20-4(Betamethasone 17,21-dipropionate)Related Search:
BETAMETHASONE 17,21-DI-PROPIONATE
BETAMETHASONE 17-ALPHA,21-DIPROPIONATE
1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17,21-DIPROPIONATE
9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17,21-DIPROPIONATE
Betamethasonediproprionate
9--Fluoro-16--methyl-11,17,21-trihydroxy-1,4-pregnadiene-3,20-dione17,21-dipropionate
BETANMETHASONE DIPROPIONATE
BETAMETHASONEDIPROPIONATE,MICRONIZEDPOWDER,USP
Diprophos
Maxivate
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)-
Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 17,21-dipropionate (7CI, 8CI)
Psorion
Rinderon DP
S 3440
Sch 11460
β-Methasone 17,21-dipropionate
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17,21-Dipropionate
17,21-Di(propionyloxy)-9-fluoro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione
[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
propionic acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-3-keto-10,13,16-trimethyl-17-(2-propionyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
Betamethasone 17,21-dipropionate,9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate
Betamethasone Dipropionate (125 mg)
Betamethasone 17,21-
9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate
Betamethasone dipropionate for peak identification
Betamethasone dipropionate for system suitability
17,21 betaMethasone dipropionate ester
diproderm
diprosis
9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
Betanmethasone Dipronate
Pregna-1,4-Diene-3,20-Dione,9-Fluoro-11-Hydroxy-16-Methyl-17,21-Bis(1-Oxopropoxy)-,(11Beta,16Beta)-
(11-beta,16-beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate
Betamethaasone Dipropionate
99% High Purity Raw Powder Betamethason 17, 21-Dipropionate CAS 5593-20-4
Betamethasone dipropionate (B1040000)Q: What is
Betamethasone dipropionate (B1040000) Q: What is the CAS Number of
Betamethasone dipropionate (B1040000)
Betamethasone dipropionate for peak identification (Y0001416)
Betamethasone dipropionate for system suitability A (Y0001925)
Betamethasone DipropionateQ: What is
Betamethasone Dipropionate Q: What is the CAS Number of
Betamethasone Dipropionate Q: What is the storage condition of
Betamethasone Dipropionate
Betamethasone Dipropionate (1067704)
AT-13387 lactate
ATI-13387A
ATI-13387AU
propanoic acid [2-[(8R,9S,10R,11S,13S,14R,16S,17R)-8-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(1-oxopropoxy)-6,7,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester
Betamethasone 17,21-dipropionate, ≥97.0%
Betamethasone 17,21-dipropionate(5593-20-4)
Betamethasone dipropionate for peak identification CRS
Betamethasone 17,21-Dipropionate >
Betamethasone dipropionate CRS
Diprolene AF
Betamethasone dipropionate for system suitability A
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Anhydrous Beclometasone Dipropionate
Betamethasone dipropionate solution in Acetonitrile, 100μg/mL
Pregna-1,4-diene-3,20-dione,9-fluoro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)-
Betamethasone 17,21-dipropionate USP/EP/BP