NOGALAMYCIN
- CAS No.
- 1404-15-5
- Chemical Name:
- NOGALAMYCIN
- Synonyms
- U-15167;U 15167;nsc-70845;noramycin;AIDS031122;NOGALAMYCIN;nogalomycin;Nogalamyicn;Nogalamycine;Nogalamycinum
- CBNumber:
- CB3752063
- Molecular Formula:
- C39H49NO16
- Molecular Weight:
- 787.8
- MDL Number:
- MFCD00083442
- MOL File:
- 1404-15-5.mol
| Melting point | 195-196° (dec) |
|---|---|
| alpha | D25 +425° (c = 0.11 in CHCl3) |
| Boiling point | 658.61°C (rough estimate) |
| Density | 1.2095 (rough estimate) |
| refractive index | 1.7650 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble |
| form | A solid |
| pka | 7.45 (60% ethanol) |
| color | Orange-red solid from MeOH |
| biological source | Streptomyces nogalater |
| EWG's Food Scores | 1 |
| FDA UNII | L059DCD6IP |
| UNSPSC Code | 51111755 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H332-H350-H360 | |||||||||
| Precautionary statements | P201-P280-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-46-61-20/21/22 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RA4550000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian) | |||||||||
| NFPA 704 |
|
NOGALAMYCIN price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27995 | Nogalamycin | 1404-15-5 | 5mg | $219 | 2024-03-01 | Buy |
| Cayman Chemical | 27995 | Nogalamycin | 1404-15-5 | 25mg | $761 | 2024-03-01 | Buy |
| TRC | N888503 | Nogalamycin | 1404-15-5 | 10mg | $1320 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009018 | NOGALAMYCIN 95.00% | 1404-15-5 | 5MG | $500.62 | 2021-12-16 | Buy |
| AHH | MT-57169 | Nogalamycin 98% | 1404-15-5 | 0.05g | $370 | 2021-12-16 | Buy |
NOGALAMYCIN Chemical Properties,Uses,Production
Uses
Nogalamycin (cas# 1404-15-5) is a compound useful in organic synthesis.
Uses
Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.
Definition
ChEBI: Nogalamycin is an anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties. It has a role as an antineoplastic agent, a cardiotoxic agent, a bacterial metabolite and an intercalator. It is a methyl ester, a polyketide, an anthracycline antibiotic, a tertiary amino compound, a monosaccharide derivative, an organic heterohexacyclic compound and a tetrol.
Biochem/physiol Actions
Anthracyclic antitumor antibiotic.
Safety Profile
Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.
in vivo
Nogalamycin (0-1000 mug/kg; IP) can regress chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats[3].
| Animal Model: | Rats[1] |
| Dosage: | 0-1000 mug/kg |
| Administration: | IP |
| Result: | Regressed chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats, and the most effective concentration was 556 mug/kg. |
NOGALAMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5745 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32375 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618791163155 | 18791163155@163.com | China | 3439 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9895 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4720 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
View Lastest Price from NOGALAMYCIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | Nogalamycin
1404-15-5
|
US $548.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Nogalamycin
1404-15-5
- US $548.00 / mg
- TargetMol Chemicals Inc.
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