ChemicalBook >> CAS DataBase List >>11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Structure](CAS/GIF/111974-74-4.gif)
- CAS No.
- 111974-74-4
- Chemical Name:
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
- Synonyms
- Quetiapine EP Impurity B;Norquetiapine dihydrochloride salt;QuetiapineEPImpurityB2HCl;Quetiapine DBTP Metabolite;Quetiapine Impurity-B/RC-2;Quetiapine Impurity B DiHCl;11-(1-Piperazinyl)-dibenzo[b;4]thiazepine dihydrochloride;Quetiapine Related CoMpound B;Norquetiapine dihydrochloride
- CBNumber:
- CB3854879
- Molecular Formula:
- C17H18ClN3S
- Molecular Weight:
- 331.86
- MDL Number:
- MFCD08703302
- MOL File:
- 111974-74-4.mol
Last updated:2024-03-22 11:53:02
| Melting point | 180-184°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO, Methanol, Distilled Water |
| form | solid |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H |
| InChIKey | MJPARFLICDXWJT-UHFFFAOYSA-N |
| SMILES | C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl |
| CAS DataBase Reference | 111974-74-4(CAS DataBase Reference) |
| FDA UNII | 7VJ4TC63IL |
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | KIT1365 | N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride(1.0mg/mLinMethanol) | 111974-74-4 | 10x1ml | $145 | 2021-12-16 | Buy |
| TRC | D288740 | N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride | 111974-74-4 | 5g | $155 | 2021-12-16 | Buy |
| AK Scientific | J11616 | QuetiapineEPImpurityB2HCl | 111974-74-4 | 25mg | $39 | 2021-12-16 | Buy |
| Matrix Scientific | 090783 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride 95+% | 111974-74-4 | 1g | $114 | 2021-12-16 | Buy |
| Matrix Scientific | 090783 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride 95+% | 111974-74-4 | 5g | $303 | 2021-12-16 | Buy |
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties,Uses,Production
Description
Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Chemical Properties
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
Uses
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
Uses
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
References
1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 256)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 8382 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
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| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride pictures](/ProductImageEN/2024-03/Small/db263647-deba-46b7-bd3e-1c15c4ca4be1.jpg) |
2024-04-28 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
|
|
2024-04-28 | 1-Methylindole-3-carboxaldehyde
111974-74-4
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride pictures](/ProductImageEN/2024-01/Small/0e056736-5cab-4b89-9a8d-50d7db5ea28a.jpg) |
2024-01-31 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- 1-Methylindole-3-carboxaldehyde
111974-74-4
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
111974-74-4(11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride)Related Search:
Quetiapine Carboxylate Impurity
2-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)ethanol dihydrochloride
Quetiapine Dimer Impurity
2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl Acetate
Quetiapine Hydroxy Impurity
Quetiapine N-Oxide
1,2-Bis[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethane
10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine
Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate))
N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-1-carbonyl)phenyl)thio)phenyl)acetaMide
1of4
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP,
11-Piperazin-1-yl-dibenzo[B,F][1,4]thiazepine dihydrochloride
Dibenzo[b,f][1,4]thiazepine, 11-(1-piperazinyl)-, hydrochloride (1:2)
11-PIPERAZIONDIBENZO[b,f][1,4]THIAZEPINE DIHYDROCHLORIDE
dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine
dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dihydrochloride
11-Piperazinodibenzo-[b,f][1,4]-thiazepin
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine 2HCl
Quetiapine IMpurity A (DBTP Metabolite)
Quetiapine DBTP Metabolite
Quetiapine Related CoMpound B
11-piperazinyl-dibenzo d,f 1,4 thiazepine dihydrochloride
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (1.0 Mg/ML in Methanol)
Quetiapine Impurity B DiHCl
11-(1-piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
11-Piperazinodibenzo[b,f][1,4]thiazepine dihydrochloride
11-PIPERAZINYL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCl (DBTP)
11-Piperazynil-Dibenzo[b,f][1,4]Thiazepine DIHYDROCHLORIDE
DibenzoB,F1,4Thiazepine-11-Piperazine2Hcl
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine,2HCl
N-Des[2-(2-hydroxyethoxy)ethyl]Quetiapinedihydrochloride
N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazine2HCl
N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazinedihydrochloride
Dibenzo[b,f][1,4] thiazepine-11-amine Hydrochloride
11-Piperazynil-dibenzo (b,f)(1,4)thiazepine-11-piperazine 2HCl
1-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPINEDIHYDROCHLORIDE
11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
11-PIPERAZYNIL-DIBENZO[B,F][1,4] THIAZEP
Quetiapine EP Impurity B DiHCl
Quetiapine Impurity 28(Quetiapine EP Impurity B)
11-(1-Piperazinyl)-dibenzo[b
4]thiazepine dihydrochloride
11-(Piperazin-1-yl)dibenzo[b,f][1,4
Norquetiapine dihydrochloride
11-Piperazinodibenzo[b,f][1,4]thiazepine DiHCl
11-Piperazynil-dibenzo[b,f][1,4]thiazepine dihydrochloride (DBTP)
11-(piperazine-1-yl)dienzo[b,f][1,4]thiazepine
hydrochloride
Quetiapine Fumarate EP Impurity B
Quetiapine EP Impurity B/ Quetiapine Related Compound B (Quetiapine DBTP Metabolite)
Quetiapine Impurity-B/RC-2
11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine DihydrochlorideQ: What is
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the CAS Number of
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the storage condition of
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What are the applications of
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride
111974-74-4 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine（Quetiapine EP Impurity B)
Quetiapine Related Compound B (11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine dihydrochloride) (1592737)
Quetiapine EP Impurity B
Norquetiapine dihydrochloride salt
Quetiapine Impurity B (EP) DiHCl
Quetiapine Related Compound B as Dihydrochloride
Quetiapine USP Related Compound B as Dihydrochloride
11-(1-piperazinyl)-Dibenzo[b,f][1,4]thiazepine hydrochloride (1:2)
11-Piperazinodibenzo-[b,f][1,4]-thiazepin dihydrochloride
11-piperazine-dibenzo [b,f][1,4] thiazepine dihydrochloride
Quetiapine Fumarate EP Impurity B as Dihydrochloride
QuetiapineEPImpurityB2HCl
Quetiapine EP Impurity B Dihydrochloride