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Eletriptan hydrobromide

Eletriptan hydrobromide structure

CAS No.: 177834-92-3

Chemical Name:: Eletriptan hydrobromide

Synonyms: Relert;Uk 116044-04;Eletriptan HCl;ELETRIPTAN HBR;Eletriptan Base;Unii-m41W832ta3;Eletriptan-d3 HBr;QR-2008082103-ELCPT;etriptan hydrobromide;eletriptan hydrobromide

CBNumber:: CB3854925

Molecular Formula:: C22H27BrN2O2S

Molecular Weight:: 463.43

MDL Number:: MFCD18642857

MOL File:: 177834-92-3.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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Eletriptan hydrobromide Properties

Melting point	169-171?C
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: >10mg/mL
form	powder
color	off-white to light tan
InChIKey	PWVXXGRKLHYWKM-IBGZPJMESA-N
FDA UNII	M41W832TA3

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H302-H318-H412
Precautionary statements	P264-P270-P273-P280-P301+P312-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36
Safety Statements	26
WGK Germany	3
HS Code	29339900

Eletriptan hydrobromide price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3032	Eletriptan hydrobromide ≥98% (HPLC)	177834-92-3	10MG	$94.2	2024-03-01	Buy
Sigma-Aldrich	SML3032	Eletriptan hydrobromide ≥98% (HPLC)	177834-92-3	50MG	$306	2024-03-01	Buy
Sigma-Aldrich	1234453	Eletriptan Hydrobromide United States Pharmacopeia (USP) Reference Standard	177834-92-3	200MG	$715	2024-03-01	Buy
TRC	R143400	Relpax	177834-92-3	25mg	$230	2021-12-16	Buy
AK Scientific	J99624	Eletriptan hydrobromide	177834-92-3	25mg	$221	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML3032	10MG	$94.2	Buy
SML3032	50MG	$306	Buy
1234453	200MG	$715	Buy
R143400	25mg	$230	Buy
J99624	25mg	$221	Buy

Eletriptan hydrobromide Chemical Properties,Uses,Production

Chemical Properties

Eletriptan hydrobromide is Tan Solid

Originator

Relpax,Pfizer

Uses

Relpax is a second generation triptan drug used in the treatment of migraine headaches.

Uses

antibiotic

Uses

Eletriptan hydrobromide is a second generation triptan drug used in the treatment of migraine headaches.

Definition

ChEBI: Eletriptan hydrobromide is a hydrobromide. It has a role as a serotonergic agonist, a vasoconstrictor agent and a non-steroidal anti-inflammatory drug. It contains an eletriptan(1+).

Manufacturing Process

A mixture of the appropriate phenyl vinyl sulfone, tri-o-tolylphosphine, palladium (II) acetate, triethlamine and (R)-5-bromo-3-(Nmethylpyrrolidinylmethyl)-1H-indole in anhydrous acetonitrle was heated at reflux under nitrogen. The resultant reaction mixture was evaporated under reduced pressure, and the residue was column chromatographed using silica gel and elution with methylene chloride/absolute ethanol/ammonia to afford the (R )-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)- 1H-indole.
A solution of (R)-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2- ylmethyl)-1H-indole and 10% Pd/C in ethanolic hydrogen chloride (prepared from absolute ethanol and acetyl chloride and N,N-dimethylformamide was shaken under a hydrogen atmosphere at room temperature). The resultant reaction mixture was filtered through diatomaceous earth (Celite trademark), washed with absolute ethanol, and the combined filtrates were evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic phase was separated, washed with water, brine, dried(Na2SO4), and evaporated under reduced pressure to afford a oil product. Column chromatography of this product using silica gel and elution with methylene chloride/absolute ethanol/ammonia afforded the appropriate (R)-5- (2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole.
The salt eletriptan hydrobromide may be produced by reaction of the (R)-5- (2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole with hydrobromic acid.

brand name

Relpax (Pfizer).

Therapeutic Function

Serotonin agonist

Biological Activity

Orally active, selective 5-HT 1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo . Displays antimigraine activity.

storage

room temperature (desiccate)

Eletriptan hydrobromide synthesis

Synthesis of Eletriptan hydrobromide from Eletriptan

Eletriptan hydrobromide Preparation Products And Raw materials

Raw materials

Phosphine Hydrochloric acid Hydrogen bromide Triethylamine Phenyl vinyl sulfone

Palladium hydroxide 2-Methylindole Palladium (II) Acetate 1-Pyrrolidinecarboxylic acid, 2-[(5-bromo-1H-indol-3-yl)carbonyl]-, phenyl ester, (2R)- (R)-pyrrolidine-1,2-dicarboxylic acid 1-phenyl ester

(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole hydrobromide Eletriptan Hydrobromide Monohydrate 3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE (R)-N-Acetyl-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

(R)-5-BROMO-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-1H-INDOLE Eletriptan (R)-5-Bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole

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Preparation Products

Eletriptan hydrobromide Suppliers

Global( 203)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	906	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	13854	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Cangzhou Wanyou New Material Technology Co.,Ltd	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
WinWin Chemical CO., Limited	58

View Lastest Price from Eletriptan hydrobromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-11	Eletriptan hydrobromide 177834-92-3	US $10.00 / KG	1g	99	2000kg	Shijiazhuang tongyang Import and Export Co., LTD
2019-07-31	Eletriptan hydrobromide 177834-92-3	US $1.00 / g	1g	99%	8000 Kilogram/Kilograms per Month	Cangzhou Wanyou New Material Technology Co.,Ltd
2019-07-06	Eletriptan hydrobromide 177834-92-3	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

Eletriptan hydrobromide
177834-92-3
US $10.00 / KG
99
Shijiazhuang tongyang Import and Export Co., LTD

Eletriptan hydrobromide
177834-92-3
US $1.00 / g
99%
Cangzhou Wanyou New Material Technology Co.,Ltd

Eletriptan hydrobromide
177834-92-3
US $2.00 / kg
99%
Career Henan Chemical Co

Eletriptan hydrobromide Spectrum

Eletriptan hydrobromide(177834-92-3)¹HNMR

177834-92-3(Eletriptan hydrobromide)Related Search:

Bensulfuron methyl Thiophanate-methyl Eletriptan Scopolamine hydrobromide Hydrogen bromide

METSULFURON METHYL Methylparaben Kresoxim-methyl Dextromethorphan hydrobromide monohydrate Methyl salicylate

Methyl acetate Citalopram hydrobromide Zolmitriptan Galantamine Hydrobromide Tri(o-tolyl)phosphine

Methyl Parathion-methyl DEXTROMETHORPHAN HYDROBROMIDE

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Unii-m41W832ta3 Relpax Also see: E505000 Eletriptan HCl 1H-Indole,3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-,hydrobromide (R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(N-Methylpyrrolidin-2-yl)Methyl]-1H-indole hydrobroMide Relert (R)-3-((1-Methylpyrrolidin-2-yl)Methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole hydrobroMide eletriptan hydrobromide 3-(((2r)-1-methyl-2-pyrrolidinyl))methyl)-5-(2-(phenylsulfonyl)ethyl)-1h-indole hydrobromide ELETRIPTAN HBR Eletriptan Base 1H-Indole, 3-(((2R)-1-methyl-2-pyrrolidinyl))methyl)-5-(2-(phenylsulfonyl)ethyl)-, monohydrobromide Uk 116044-04 Eletriptan hydrobromide (Eletriptan HBr) Eletriptan hydrobromide, 99%, a selective 5-HT1B/1D receptor agonist 5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole hydrobromide Eletriptan-d3 HBr etriptan hydrobromide Eletriptan hydrobromide USP/EP/BP QR-2008082103-ELCPT Eletriptan Related compound 01 Eletriptan HydrobromideQ: What is Eletriptan Hydrobromide Q: What is the CAS Number of Eletriptan Hydrobromide Q: What is the storage condition of Eletriptan Hydrobromide Q: What are the applications of Eletriptan Hydrobromide 177834-92-3 Eletriptan hydrobromide 1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-, hydrobromide (1:1) 177834-92-3 C22H26N2O2SHBr C22H26N2O2SBrH C22H27BrN2O2S Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pfizer compounds Pharmaceuticals