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KARAKOLINE

CAS No.
39089-30-0
Chemical Name:
KARAKOLINE
Synonyms
Karacoline;Carmicheline(7CI);Inhibitor,Karacoline,inhibit;(16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol;(1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol;Aconitane-1,8,14-triol,20-ethyl-16-methoxy-4-methyl-, (1a,14a,16b)-;Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-;11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-1,8,14-triolderiv.
CBNumber:
CB3986952
Molecular Formula:
C22H35NO4
Molecular Weight:
377.52
MDL Number:
MFCD00274546
MOL File:
39089-30-0.mol
MSDS File:
SDS

KARAKOLINE Properties

Melting point 185-186℃ (acetone )
Boiling point 540.2±50.0 °C(Predicted)
Density 1.30±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 2-8°C
pka 13.80±0.70(Predicted)

SAFETY

Risk and Safety Statements

RTECS  AR5569480

KARAKOLINE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC K139700 Karacoline 39089-30-0 1mg $140 2021-12-16 Buy
TRC K139700 Karacoline 39089-30-0 10mg $580 2021-12-16 Buy
ApexBio Technology N2030 Karacoline 39089-30-0 20mg $600 2021-12-16 Buy
ChemScene CS-0027924 Karacoline 39089-30-0 10mg $743 2021-12-16 Buy
ChemScene CS-0027924 Karacoline 39089-30-0 5mg $457 2021-12-16 Buy
Product number Packaging Price Buy
K139700 1mg $140 Buy
K139700 10mg $580 Buy
N2030 20mg $600 Buy
CS-0027924 10mg $743 Buy
CS-0027924 5mg $457 Buy

KARAKOLINE Chemical Properties,Uses,Production

Description

A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.

Uses

Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.

Definition

ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a d methoxy groups, respectively.

References

Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973)

KARAKOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 68)Suppliers
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Chengdu GLP biotechnology Co Ltd
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Shaanxi Pioneer Biotech Co., Ltd .
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Hubei Ipure Biology Co., Ltd
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Chengdu Youngshe Chemical Co., Ltd.
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TargetMol Chemicals Inc.
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ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
(16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol Karacoline Aconitane-1,8,14-triol,20-ethyl-16-methoxy-4-methyl-, (1a,14a,16b)- Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)- Carmicheline(7CI) 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-1,8,14-triolderiv. (1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol Inhibitor,Karacoline,inhibit 39089-30-0 Alkaloids chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract