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Vorozole

CAS No.
129731-10-8
Chemical Name:
Vorozole
Synonyms
R-83842;Vorozol;Rivizor;Vorozolum;Ccris 7482;Vorozolum [inn-latin];Vorozol [inn-spanish];6-[(S)-(4-Chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-1H-benzotriazole;(+)-6-[(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole;1H-Benzotriazole, 6-[(S)-(4-chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-
CBNumber:
CB41180066
Molecular Formula:
C16H13ClN6
Molecular Weight:
324.77
MDL Number:
MOL File:
129731-10-8.mol
Last updated:2023-05-04 17:34:32

Vorozole Properties

Melting point 130-135°
alpha D20 +8.0° (c = 10 in CH3OH)
Boiling point 575.1±60.0 °C(Predicted)
Density 1.44
pka 1.87±0.11(Predicted)
FDA UNII 1E2S9YXV2A

Vorozole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0025281 VOROZOLE 95.00% 129731-10-8 5MG $502.89 2021-12-16 Buy
Product number Packaging Price Buy
API0025281 5MG $502.89 Buy

Vorozole Chemical Properties,Uses,Production

Originator

Vorozole,Janssen Pharmaceutica

Uses

Antineoplastic.

Definition

ChEBI: Vorozole is a member of benzotriazoles.

Manufacturing Process

To a stirred solution of 28.4 parts of 1H-1,2,4-triazole in 135 parts of N,N- dimethylformamide were added 11.4 parts of a sodium hydride dispersion 80% under nitrogen atmosphere. After stirring for 1 hour at room temperature, a solution of 40 parts of 6-[chloro(4-chlorophenyl)-methyl]-1- methyl-1H-benzotriazole in 90 parts of N,N-dimethylformamide was added to the mixture. The whole was stirred for 1 hour at 60°C. The reaction mixture was diluted with 50 parts of water and the whole was evaporated. The residue was extracted with ethyl acetate. The extract was washed with water, dried, filtered and evaporated. The residue was purified by column chromatography over silica gel using a mixture of dichloromethane and methanol (99:1 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was crystallized from a mixture of 2-propanone and 1,1'-oxy-bis-ethane (ether). The product was filtered off and dried, yielding 13 parts (29.2%) of 6-[(4-chlorophenyl)-(1H-1,2,4-triazol-1-yl)methyl]-1-methyl- 1H-benzotriazole; MP: 178.9°C. A resolution of enantiomers any usual method gave crystals from 2-propanol, MP: 130-135°C. [α] D 20 = 8.0° (plus or minus) (c = 10 in CH 3 OH).

brand name

Rivizor (Janssen).

Therapeutic Function

Antineoplastic

Vorozole Preparation Products And Raw materials

Raw materials

Preparation Products

Vorozole Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Shanghai Yanze Chemical Co., Ltd. 13773155751 19975051755 260924549@QQ.com China 3675 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Shanghai Yanze Chemical Co., Ltd. 15345144255 260924549@qq.com China 3570 58
Shanghai Yanze Chemical Co., Ltd 021-13621551597 19901447308 260924549@qq.com China 6456 58
(+)-6-[(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole R-83842 1H-Benzotriazole, 6-((4-chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl)-1-methyl-, (S)- Ccris 7482 Vorozol Vorozol [inn-spanish] Vorozolum Vorozolum [inn-latin] 6-[(S)-(4-Chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl-1H-benzotriazole Rivizor (S)-6-((4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1-methyl-1H-benzo[d][1,2,3]triazole 1H-Benzotriazole, 6-[(S)-(4-chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl]-1-methyl- 129731-10-8