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Ascorbyl Palmitate

CAS No.
137-66-6
Chemical Name:
Ascorbyl Palmitate
Synonyms
ASCORBIC ACID 6-PALMITATE;Vitamin C Palmitate;Palmitoyl ascorbate;L-ASCORBYL PALMITATE;PALMITOYL L-ASCORBIC ACID;E304;scorbic;ascorbyl;Ascorbate palmitate;L-ASCORBYL 6-PALMITATE
CBNumber:
CB4121121
Molecular Formula:
C22H38O7
Molecular Weight:
414.53
MDL Number:
MFCD00005377
MOL File:
137-66-6.mol
Last updated:2023-11-14 17:47:09

Ascorbyl Palmitate Properties

Melting point 115-118 °C(lit.)
alpha +21~+26°(20℃/D, c=2, C2H5OH)
Boiling point 512.7±50.0 °C(Predicted)
Density 1.150±0.06 g/cm3(Predicted)
refractive index 22.5 ° (C=1, EtOH)
storage temp. 2-8°C
solubility Slightly soluble in ethyl alcohol.
pka 3.96±0.10(Predicted)
color White to Pale Gray
Odor wh. or yel.-wh. powd., citrus odor
optical activity [α]20/D +23±1°, c = 1% in ethanol
BRN 96552
InChIKey QAQJMLQRFWZOBN-UWJYYQICSA-N
LogP 6.5 at 30℃ and pH1.9
FDA 21 CFR 182.3149; 582.3149
Substances Added to Food (formerly EAFUS) ASCORBYL PALMITATE
SCOGS (Select Committee on GRAS Substances) Ascorbyl palmitate (palmitoyl L-ascorbic)
CAS DataBase Reference 137-66-6(CAS DataBase Reference)
FDA UNII QN83US2B0N
EPA Substance Registry System Ascorbyl palmitate (137-66-6)
Cosmetics Info Ascorbyl Palmitate

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-24/25
WGK Germany  1
RTECS  CI7671040
TSCA  Yes
HS Code  2936 27 00
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
NFPA 704
1
2 0

Ascorbyl Palmitate price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 76183 6-O-Palmitoyl-L-ascorbic acid BioXtra, ≥99.0% (RT) 137-66-6 25g $64.5 2024-03-01 Buy
Sigma-Aldrich 5.00090 L(+)Ascorbyl palmitate EMPROVE? ESSENTIAL Ph Eur,BP,NF,FCC,E 304 137-66-6 2.5kg $1367 2024-03-01 Buy
Sigma-Aldrich 5.00090 L(+)Ascorbyl palmitate EMPROVE? ESSENTIAL Ph Eur,BP,NF,FCC,E 304 137-66-6 10Kg $3964 2024-03-01 Buy
Sigma-Aldrich 1043105 Ascorbyl Palmitate United States Pharmacopeia (USP) Reference Standard 137-66-6 500mg $491 2024-03-01 Buy
Sigma-Aldrich 02134 6-O-Palmitoyl-L-ascorbic acid analytical standard 137-66-6 500MG $70 2022-05-15 Buy
Product number Packaging Price Buy
76183 25g $64.5 Buy
5.00090 2.5kg $1367 Buy
5.00090 10Kg $3964 Buy
1043105 500mg $491 Buy
02134 500MG $70 Buy

Ascorbyl Palmitate Chemical Properties,Uses,Production

Description

Ascorbyl palmitate is a lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays. Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil. It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA; ) in mice in a concentration-dependent manner when applied topically. Ascorbyl palmitate (0.8 and 4 μmol per 200 μl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics.

Chemical Properties

Ascorbyl palmitate is a white or yellowish-white solid with a soapy taste and a citrus-like odor. It is very slightly soluble in water but freely soluble in alcohol, animal oil, and vegetable oil. It melts at 107° to 117°C (around 234°F). Ascorbyl palmitate prevents oxidative rancidity development by quenching singlet oxygen. The ascorbic acid part of the molecule donates hydrogen (a reducing agent). This phenomenon is also called "oxygen scavenging".

Uses

Ascorbyl Palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat soluble form of vitamin C. It is used as an antioxidant food additive. It is also used as a preservative and an anti-oxidant in cosmetic creams and lotions to prevent rancidity. Ascorbyl palmitate facilitates the incorporation of ingredients such as vitamins A, C, and D into cosmetic formulations. It has no known toxicity.

Production Methods

Ascorbyl palmitate is prepared synthetically by the reaction of ascorbic acid with sulfuric acid followed by reesterification with palmitic acid.

Application

Ascorbyl Palmitate is an antioxidant formed by combining ascorbic acid with palmitic acid. ascorbic acid is not fat soluble but ascorbyl palmitate is, thus combining them produces a fat-soluble antioxidant. it exists as a white or yellowish white powder of citric- like odor. it is used as a preservative for natural oils, edible oils, colors, and other substances. it acts synergistically with alpha-tocopherol in oils/fats. it is used in peanut oil at a maximum level of 200 mg/kg individually or in combination.

Definition

ChEBI: Ascorbyl palmitate is a fatty acid ester. It is derived from corn dextrose fermentation and palm oil. It is used as a food preservative and as an antioxidant in oils, fats, and pharmaceuticals.

General Description

A white or yellowish-white powder having a citrus-like odor. Mp 116–117°C; soluble in alcohol and in animal and vegetable oils; slightly soluble in water. Ascorbyl Palmitate is a lipophilic ascorbic acid derivative, used as an antioxidant in both food and cosmetics industries.

Pharmaceutical Applications

Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used. It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen. The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced.
The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions.

Biochem/physiol Actions

6-O-Palmitoyl-L-ascorbic acid possesses metastasis inhibitory and anti-tumor activity. Ascorbyl palmitate exhibits antioxidant activity by protecting the cell membranes from oxidative damage.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Ascorbyl palmitate is used in oral pharmaceutical formulations and food products, and is generally regarded as an essentially nontoxic and nonirritant material. The WHO has set an estimated acceptable daily intake for ascorbyl palmitate at up to 1.25 mg/kg bodyweight.
LD50 (mouse, oral): 25 g/kg
LD50 (rat, oral): 10 g/kg

storage

Ascorbyl palmitate is stable in the dry state, but is gradually oxidized and becomes discolored when exposed to light and high humidity. In an unopened container, stored in a cool place, it has a shelf life of at least 12 months. During processing, temperatures greater than 658℃ should be avoided.
The bulk material should be stored in an airtight container at 8–158℃, protected from light.

Incompatibilities

Incompatibilities are known with oxidizing agents; e.g. in solution oxidation is catalyzed by trace metal ions such as Cu2+ and Fe3+.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, rectal, topical preparations). Included in nonparenteral medicines licensed in the UK.

623-65-4
57-10-3
50-81-7
137-66-6
Synthesis of Ascorbyl Palmitate from Palmitic anhydride and Palmitic acid and Ascorbic Acid
Global( 611)Suppliers
Supplier Tel Email Country ProdList Advantage
Huizhou Comvikin Biotechnology Co., Ltd
+86-86-18928328158 +8618928328158 alice1@comvikin.com China 1 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040 sales@myuchem.com China 6506 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Hebei Xinsheng New Material Technology Co., LTD.
+86-16632316109 xinshengkeji@xsmaterial.com China 1104 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682 bruce@xrdchem.cn CHINA 566 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58

View Lastest Price from Ascorbyl Palmitate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ascorbyl Palmitate pictures 2024-03-19 Ascorbyl Palmitate
137-66-6
US $55.00 / KG 1KG 99% 1000kg Hebei Yime New Material Technology Co., Ltd.
ASCORBYLPALMITATE pictures 2024-02-23 ASCORBYLPALMITATE
137-66-6
US $8.00-48.00 / g 25g 0.98 100kg Shanghai UCHEM Inc.
6-O-palmitoyl-L-ascorbic acid pictures 2023-10-23 6-O-palmitoyl-L-ascorbic acid
137-66-6
US $25.00-15.00 / kg 1kg 99 20tons Hebei Xinsheng New Material Technology Co., LTD.
6-O-Palmitoyl ascorbate Ascorbyl Palmitate (2 g) Ascorbyl Palmitate (2 g) (AS) ASCORBYL PALMITATE(ASCORBIC ACID-6-PALMITATE)(P) Ascorbyl palMitate / 6-PalMitoylascorbic acid VitaMin C Oil Soluble /L-Ascorbyl PalMitate ASCORBIC ACID PALMITATE ASCORBYL PALMITATE L(+)ASCORBYL PALMITATE L-ASCORBIC ACID PALMITATE L-ASCORBIC ACID, 6-HEXADECANOATE (S)-2-((R)-3,4-Dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl palMitate ASCORBYL PALMITATE(RG) Ascorbyl palMitate USP Ascorbyl palMi NSC 402451 Ascorbyl Palmitate (500 mg) 6-O-Palmitoyl-L-ascorbic acid Vetec(TM) reagent grade, 95% ASCORBIC ACID 6-PALMITATE, VETEC 6-hexadecanoyl-l-ascorbicacid 6-monopalmitoyl-l-ascorbate 6-o-palmitoylascorbicacid ascorbicacidpalmitate(ester) ascorbicpalmitate ascorbylmonopalmitate ascorbylpalmiticacid cetylascorbate l-ascorbylmonopalmitate ondascora quicifal scorbicpalmitate [2-(4,5-DIHYDROXY-3-OXO-2-FURYL)-2-HYDROXY-ETHYL] HEXADECANOATE 6-O-HEXADECANOYL-L-ASCORBIC ACID 6-PALMITOYLASCORBIC ACID Ascorbylpalmitate,95% Ascorbyl palmitate FCCIV L-ascoryl palitate Ascorbyl palmitate BP/USP/FCC L-ASCORBIC ACID 6-PALMITATE USP (S)-2-[(R)-3,4-dihydroxy-5-oxo-2,5-dihydro-2-furyl]-2-hydroxyethyl hexadecanoate ASCORBYLPALMITATE,FCC Ascorbyl Palmitate(BP/EP/USP/FCC) ASCORBYL PALMITATE(ASCORBIC ACID-6-PALMITATE)(SH) ASCORBYL PALMITATE(USP)(RG) 6-0-PALMITOYL-L-ASCORBICACID 6-O-Palmitoylascorbinsure L-ASCORBINSAEURE 6-PALMITAT 6-O-Palmitoyl-L-ascorbic acid, L-Ascorbyl palmitate, Ascorbic acid 6-palmitate L-Ascorbyl palmitate, Ascorbic acid 6-palmitate LGB-AP Ascorbyl palmitate CRS 6-O-Palmitoyl-L-ascorbic Acid > L-Ascorbyl 6-palmitate, 95%, for bio Ascorbyl Palmitate Basic information Ascorbyl Palmitate USP/EP/BP High Quality Ascorbyl Palmitate, CAS 137-66-6, Ascorbyl Palmitate Powder [(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] hexadecanoate L-ASCORBYL PALMITATE For Synthesis