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Maropitant citrate hydrate

CAS No.
359875-09-5
Chemical Name:
Maropitant citrate hydrate
Synonyms
2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID;ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine;4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine;(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine;Maropitant citrate hydrate;ACIDUM CITRICUM ANHYDRICUM;(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...;(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate;FEMA 2306;CT SUPPLEMENT
CBNumber:
CB4127749
Molecular Formula:
C38H48N2O8
Molecular Weight:
660.81
MDL Number:
MFCD02098080
MOL File:
359875-09-5.mol
MSDS File:
SDS
Last updated:2024-03-05 15:58:38

Maropitant citrate hydrate Properties

Melting point 153-159 °C(lit.)
Flash point 100 °C
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form white to off-white crystalline powder
Water Solubility Water: 3 mg/mL (4.42 mM)
InChIKey XDZPFSKCXRGRIO-OHTRWSNQNA-N
SMILES C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r|
CAS DataBase Reference 359875-09-5(CAS DataBase Reference)
FDA UNII LXN6S3999X

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS08,GHS09,GHS05
Signal word  Danger
Hazard statements  H400-H373-H318-H410
Precautionary statements  P273-P391-P501-P273-P391-P501-P260-P314-P501-P280-P305+P351+P338-P310
Hazard Codes  Xi,T
Risk Statements  41-42/43-36/37/38-25
Safety Statements  26-39-45-36/37-22
RIDADR  UN 3284 6.1/PG 3
WGK Germany  1
RTECS  GE7350000
9

Maropitant citrate hydrate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 77981 CT Supplement for microbiology 359875-09-5 5amp $145 2024-03-01 Buy
American Custom Chemicals Corporation CHM0992497 CT SUPPLEMENT 95.00% 359875-09-5 5MG $502.05 2021-12-16 Buy
Product number Packaging Price Buy
77981 5amp $145 Buy
CHM0992497 5MG $502.05 Buy

Maropitant citrate hydrate Chemical Properties,Uses,Production

Description

Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.

Uses

Anti-emetic.

Pharmacokinetics

The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.

Veterinary Drugs and Treatments

Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.

147116-67-4
77-92-9
359875-09-5
Synthesis of Maropitant citrate hydrate from (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-Methoxybenzyl)quinuclidin-3-aMine and Citric acid

Maropitant citrate hydrate Preparation Products And Raw materials

Global( 188)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Aslee Biopharmaceuticals, Inc.
28-85305008 CHINA 964 58
Hpets Biotech Company (Chongqing) Co.,ltd
+8613340353813 info@hanpets.com China 26 58
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd
+86-02223869539 +86-15560057295 trade.kilopharma@foxmail.com China 27 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5988 58
Henan Tengmao Chemical Technology Co. LTD
+8615238638457 salesvip2@hntmhg.com China 415 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 sales@dolonchem.com CHINA 2972 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244 mike_yan@xuanranglobal.com CHINA 4022 58

View Lastest Price from Maropitant citrate hydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Maropitant Citrate Monohydrate pictures 2024-02-27 Maropitant Citrate Monohydrate
359875-09-5
US $0.00 / kg 1kg 99% 100 tons Hpets Biotech Company (Chongqing) Co.,ltd
Maropitant Citrate pictures 2023-12-12 Maropitant Citrate
359875-09-5
US $110.00-90.00 / kilogram 1kilogram 99% 10 tons/per week Henan Tengmao Chemical Technology Co. LTD
Maropitant Citrate pictures 2023-11-24 Maropitant Citrate
359875-09-5
US $20.00-1.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
  • Maropitant Citrate pictures
  • Maropitant Citrate
    359875-09-5
  • US $110.00-90.00 / kilogram
  • 99%
  • Henan Tengmao Chemical Technology Co. LTD
B-HYDROXYTRICARBALLYLIC ACID HYDROXYTRICARBALLYLIC ACID FEMA 2306 CEFIXIM TELLURITE SUPPLEMENT CITRATE ION CHROMATOGRAPHY STANDARD CT SUPPLEMENT TELLURITE CEFIXIM SUPPLEMENT TIMTEC-BB SBB008922 CJ 11972 hydrate Cefixim Tellurite Supplement, Tellurite Cefixim Supplement Maropitant citrate Maropitant Citrate,CJ-11,972,ACIDUM CITRICUM ANHYDRICUM,B-HYDROXYTRICARBALLYLIC ACID,HYDROXYTRICARBALLYLIC ACID,FEMA 2306,CEFIXIM TELLURITE SUPPLEMENT,CITRATE ION CHROMATOGRAPHY STANDARD,CT SUP Maropitant citrate [USAN] Maropitant Citrate USP/EP/BP Maropitant citrate monohydrateQ: What is Maropitant citrate monohydrate Q: What is the CAS Number of Maropitant citrate monohydrate TIANFU CHEM---CT SUPPLEMENT Maropitant citrate hydrate 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID ACIDUM CITRICUM ANHYDRICUM 4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine (7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate (2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-... Malopitan citrate (2S,3S)-2-Benzhydryl-N-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine 2-hydroxypropane-1,2,3-tricarboxylate hydrate (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine citrate monohydrate Maropitant Citrate Monohydrate Pafolacianine Impurity 4 Maropitan citrate 359875-09-5 C32H40N2OC6H8O7H2O C38H50N2O9 Al2H2O4 C23H29FN4O7 API API 359875-09-5