aureothricin
- CAS No.
- 574-95-8
- Chemical Name:
- aureothricin
- Synonyms
- Propionylpyrrothione, Farcinin;5-Methyl-3-propionamidopyrrolin-4-one-[4,3-d]-1,2-dithiole;N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propanamide;N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide;Propanamide, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-;Propionopyrrothine, 5-Methyl-3-propionamidopyrrolin-4-one[4,3-d]-1,2-dithiole
- CBNumber:
- CB41334476
- Molecular Formula:
- C9H10N2O2S2
- Molecular Weight:
- 242.32
- MDL Number:
- MFCD07370147
- MOL File:
- 574-95-8.mol
- MSDS File:
- SDS
| Melting point | 260-270℃ (decomposition) |
|---|---|
| Boiling point | 479.1±45.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: partially soluble; Methanol: partially soluble |
| pka | 10.54±0.20(Predicted) |
| form | Yellow to orange solid. |
| color | Yellow |
| FDA UNII | 0KX00L19Q2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P280 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
aureothricin price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19942 | Aureothricin ≥98% | 574-95-8 | 500μg | $141 | 2024-03-01 | Buy |
| Cayman Chemical | 19942 | Aureothricin ≥98% | 574-95-8 | 1mg | $239 | 2024-03-01 | Buy |
| Cayman Chemical | 19942 | Aureothricin ≥98% | 574-95-8 | 5mg | $769 | 2024-03-01 | Buy |
| TRC | A794573 | Aureothricin | 574-95-8 | 1mg | $1000 | 2021-12-16 | Buy |
| TRC | A794573 | Aureothricin | 574-95-8 | 0.5mg | $525 | 2021-12-16 | Buy |
aureothricin Chemical Properties,Uses,Production
Uses
Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumour activity. Aureothricin is a more hydrophobic analogue of thiolutin, but has received only limited attention. Members of this class, notably thiolutin, are potent inhibitors of bacterial and yeast RNA polymerases, inhibitors of mannan and glucan formation in fungi, and inhibitors of tumour-cell induced angiogenesis in vivo.
Definition
ChEBI: Aureothricin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and propanoylamino groups, respectively. It is a moderate antimicrobial by-product of the thiolutin fermentation in various Streptomyces species. It has a role as a bacterial metabolite, an angiogenesis inhibitor, an antibacterial agent and an EC 2.7.7.6 (RNA polymerase) inhibitor. It is a dithiolopyrrolone antibiotic and a secondary carboxamide.
storage
+4°C
aureothricin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 400-400-400-9004166 18616739031 | 3007523370@qq.com | China | 52712 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |