ChemicalBook >> CAS DataBase List >>DL-BUTHIONINE-[S,R]-SULFOXIMINE
DL-BUTHIONINE-[S,R]-SULFOXIMINE
![DL-BUTHIONINE-[S,R]-SULFOXIMINE Structure](CAS/GIF/5072-26-4.gif)
- CAS No.
- 5072-26-4
- Chemical Name:
- DL-BUTHIONINE-[S,R]-SULFOXIMINE
- Synonyms
- NSC 381100;butioninesulfoximine;buthioninesulfoximine;buthioninesulfoxamine;buthioninesulphoximine;DL-BUTHIONINE-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine,99%
- CBNumber:
- CB4184630
- Molecular Formula:
- C8H18N2O3S
- Molecular Weight:
- 222.31
- MDL Number:
- MFCD00070309
- MOL File:
- 5072-26-4.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:02:53
| Melting point | 215 °C (dec.)(lit.) |
|---|---|
| Boiling point | 382.3±52.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | Fluffy Powder |
| color | White |
| Merck | 13,1520 |
| BRN | 2367136 |
| CAS DataBase Reference | 5072-26-4(CAS DataBase Reference) |
| FDA UNII | LW4108Q0BV |
| NCI Dictionary of Cancer Terms | buthionine sulfoximine |
| NCI Drug Dictionary | buthionine sulfoximine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EK7713435 | |||||||||
| F | 10 | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
DL-BUTHIONINE-[S,R]-SULFOXIMINE price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 19176 | DL-Buthionine-sulfoximine ≥99.0% (TLC) | 5072-26-4 | 1g | $331 | 2024-03-01 | Buy |
| Sigma-Aldrich | 19176 | DL-Buthionine-sulfoximine ≥99.0% (TLC) | 5072-26-4 | 5g | $690 | 2024-03-01 | Buy |
| Cayman Chemical | 23691 | D,L-Buthionine-(S,R)-sulfoximine ≥98% | 5072-26-4 | 250mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 23691 | D,L-Buthionine-(S,R)-sulfoximine ≥98% | 5072-26-4 | 500mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | B2640 | DL-Buthionine-(S,R)-sulfoximine | 5072-26-4 | 500mg | $138 | 2024-03-01 | Buy |
DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
DL-Buthionine-sulfoximine is suitable for use to:
- examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
- investigate the effect of BSO on development of bovine embryos
- inhibit GSH in several studies
- investigate the effect of GSH synthesis on oocyte maturation
Uses
A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
Uses
Biological tool for depletion of glutathione.
Definition
ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
General Description
DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Biochem/physiol Actions
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).
DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials
Raw materials
Preparation Products
DL-BUTHIONINE-[S,R]-SULFOXIMINE Suppliers
Global( 80)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006608290; 18621169109 | market03@meryer.com | China | 40241 | 62 |
5072-26-4(DL-BUTHIONINE-[S,R]-SULFOXIMINE)Related Search:
DL-BUTHIONINE (R,S)-SULFOXIMINE
DL-BUTHIONINE-[S,R]-SULFOXIMINE
DL-BUTHIONINE (S,R)-SULPHOXIME
DL-BUTHIONINE-SULFOXIMINE
2-amino-4-(s-butylsulfonimidoyl)-butanoicaci
2-amino-4-(s-butylsulfonimidoyl)butanoicacid
buthioninesulfoxamine
buthioninesulfoximine
buthioninesulphoximine
butioninesulfoximine
s-(3-amino-3-carboxypropyl)-s-butyl-sulfoximin
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-.
NSC 381100
S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine
S-butyl-DL-homocysteine (S,R)-sulfoximine
2-Amino-4-(S-butylsulphonimidoyl)butanoic acid, S-(3-Amino-3-carboxypropyl)-S-butylsulphoximine
DL-Buthionine (S,R)-sulfoxiMine, 99% 500MG
2-Amino-4-(S-butylsulfonimidoyl)butyric acid
DL-Buthionine (S,R)-sulfoximine,99%
D,L-Buthionine-(S,R)-sulfoximine (Synonyms: Butionine sulfoximine)
D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)
2-Amino-4-(butylsulfonimidoyl)butanoic acid
BSO,DL Buthionine (S,R) sulfoximine,Buthionine sulfoximine,DLButhionine(S,R)sulfoximine,Inhibitor,inhibit,Ferroptosis
5072-26-4
C8H18N2O3S
CH3CH23SONHCH2CH2CHNH2CO2H
Biochemicals and Reagents
BioChemical
Fusarinine -C Ornithinesterase
Enzyme Inhibitors by Enzyme
Enzymes, Inhibitors, and Substrates
Enzyme Inhibitors
D to K
Glutathione S-Transferase Agents
Sulfur & Selenium Compounds
D to
Drug and Xenobiotic Metabolism
Enzyme Inhibitors by Enzyme
Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism
Substrates, Inducers, Inhibitors