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4-Bromo-2-hydroxybenzoic acid

CAS No.
1666-28-0
Chemical Name:
4-Bromo-2-hydroxybenzoic acid
Synonyms
NSC 109120;4-BROMOSALICYLIC ACID;4-Bromosalicyclic acid;4-Bromosalicylic acid, >=98%;2-Hydroxy-4-bromobenzoicacid;4-bromo-2-hydoxybenzoic acid;4-BROMO-2-HYDROXYBENZOIC ACID;VLOOKUP(C4,[1]Export!$D:$H,5,0);Benzoicacid, 4-bromo-2-hydroxy-;4-Bromo-2-hydroxybenzoic acid 98%
CBNumber:
CB4196824
Molecular Formula:
C7H5BrO3
Molecular Weight:
217.02
MDL Number:
MFCD06797970
MOL File:
1666-28-0.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

4-Bromo-2-hydroxybenzoic acid Properties

Melting point 164-165°C
Boiling point 330.2±32.0 °C(Predicted)
Density 1.861±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 2.71±0.10(Predicted)
form powder
color Orange
InChI InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
InChIKey FYAKLZKQJDBBKW-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(Br)C=C1O
CAS DataBase Reference 1666-28-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xi,Xn
Risk Statements  22-52/53
Safety Statements  22-24/25-61
RIDADR  2811
WGK Germany  3
HazardClass  IRRITANT
PackingGroup 
HS Code  2918290090

4-Bromo-2-hydroxybenzoic acid price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 716421 4-Bromo-2-hydroxybenzoic acid 97% 1666-28-0 5g $147 2024-03-01 Buy
TRC B696148 4-Bromo-2-hydroxybenzoic acid 1666-28-0 1g $75 2021-12-16 Buy
Biosynth Carbosynth FB70486 4-Bromo-2-hydroxybenzoic acid 1666-28-0 50g $87.5 2021-12-16 Buy
AK Scientific R020 4-Bromo-2-hydroxybenzoic acid 1666-28-0 25g $94 2021-12-16 Buy
Biosynth Carbosynth FB70486 4-Bromo-2-hydroxybenzoic acid 1666-28-0 25g $50 2021-12-16 Buy
Product number Packaging Price Buy
716421 5g $147 Buy
B696148 1g $75 Buy
FB70486 50g $87.5 Buy
R020 25g $94 Buy
FB70486 25g $50 Buy

4-Bromo-2-hydroxybenzoic acid Chemical Properties,Uses,Production

Chemical Properties

4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.

Uses

2-Hydroxy-4-bromobenzoic acid is used as an anti-scorch agent in drug molecules and rubber industry, as well as an intermediate in the production of ultraviolet absorbers and foaming agents.

Synthesis

Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.

99-06-9
1666-28-0
Synthesis of 4-Bromo-2-hydroxybenzoic acid from 3-Hydroxybenzoic acid
Global( 248)Suppliers
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Capot Chemical Co.,Ltd.
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Fuxin Pharmaceutical
+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10297 58

View Lastest Price from 4-Bromo-2-hydroxybenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Bromo-2-hydroxybenzoic acid pictures 2023-03-21 4-Bromo-2-hydroxybenzoic acid
1666-28-0
US $0.00-0.00 / kg T 1kg T 99.9%MIN 20TONS Milestone Chemical Wuxi Co.,Ltd
4-Bromo-2-hydroxybenzoic acid pictures 2022-10-15 4-Bromo-2-hydroxybenzoic acid
1666-28-0
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
4-Bromo-2-hydroxybenzoic acid pictures 2021-07-02 4-Bromo-2-hydroxybenzoic acid
1666-28-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

4-Bromo-2-hydroxybenzoic acid Spectrum

4-BROMOSALICYLIC ACID 4-BROMO-2-HYDROXYBENZOIC ACID 4-Bromo-2-Hydroxybenzoic Acid 2-Hydroxy-4-Bromobenzoic Acid 2-Hydroxy-4-bromobenzoicacid 4-Bromo-2-hydroxybenzoic acid 98% 4-Bromosalicyclic acid 4-Bromosalicylic acid, 5-Bromo-2-carboxyphenol 4-Bromosalicylic acid, >=98% NSC 109120 Benzoicacid, 4-bromo-2-hydroxy- VLOOKUP(C4,[1]Export!$D:$H,5,0) 4-bromo-2-hydoxybenzoic acid 4-bromo-2-hydroxybenzoic acid/4-bromosalicylic acid 1666-28-0 C7H5O3Br Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Acids & Esters Bromine Compounds